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Detection of divalent copper with improved accuracy by dual suppression of electrochemiluminescent recovery
摘要： This work is to construct an electrochemiluminescent (ECL) sensor with improved accuracy for the detection of Cu2+. The improved accuracy is achieved by utilizing a reaction system to realize Cu2+ dose-dependent dual suppression of ECL recovery from gold nanoparticle-graphitic carbon nitride nanosheet nanohybrid (Au-CNNS) film. The ECL sensor shows sensitive response to Cu2+ in the concentration range of 5 nM to 500 nM with an enlarged slope, and high specificity attributed to the high affinity of CNNS-Cu2+ complex and the high catalytic activity of Cu(NH3)6 2+ to decompose H2O2 in the reaction system. The proposed ECL sensor with improved accuracy may prove valuable in future biomedical applications.
关键词： dual suppression,electrochemiluminescent sensor,copper,graphitic carbon nitride nanosheets
更新于2025-09-23 15:23:52
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Construction of acetaldehyde-modified g-C3N4 ultrathin nanosheets via ethylene glycol-assisted liquid exfoliation for selective fluorescence sensing of Ag+
摘要： We successfully prepared acetaldehyde-modified g-C3N4 ultrathin nanosheets (ACNNSs) by a simple ethylene glycol-assisted liquid exfoliation method. The introduction of acetaldehyde regulated the surface energy of g-C3N4 to better match with that of water, which improved the exfoliation efficiency. Moreover, the acetaldehyde introduces defects into the g-C3N4 structure, which can act as excitation energy traps and cause considerable variation in the fluorescence emission. Benefiting from the stable photoluminescence (PL) emission, good water solubility and biocompatibility, the obtained ACNNSs showed a selective fluorescent response to Ag+ both in aqueous solution and living cells. The strong absorption and intimate contact with Ag+, and its appropriate redox potential of ACNNSs contributed to this excellent fluorescent response. A simple and environmental friendly approach was proposed to simultaneously achieve modification and exfoliation of g-C3N4 in aqueous solution. These findings might lead to wider applications of carbon-based nanomaterials as active materials for fluorescence detection in the environment.
关键词： Graphitic carbon nitride nanosheets,Living-cell imaging,Glycol-assisted exfoliation,Fluorescent sensor,Acetaldehyde-modified,Ag+
更新于2025-09-10 09:29:36
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Dual?Wavelength Ratiometric Electrochemiluminescence Immunosensor for Cardiac Troponin I Detection
摘要： Ratiometric electrochemiluminescence (ECL) has attracted special focus in biological analysis field because it could eliminate the environmental interference to gain precise measurement. Herein, a dual?wavelength ratiometric ECL biosensor was designed for detection of cardiac troponin I (cTnI), where (4,4’?dicarboxylicacid?2,2’?bipyridyl) ruthenium(II) (Ru(dcbpy)3 2+) and Au nanoparticles loaded graphene oxide/polyethyleneimine (GPRu?Au) nanomaterial acts as an acceptor, and Au nanoparticles modified graphitic phase carbon nitride nanosheets composite (Au?CNN) acts as donor. Au?CNN shows high and steady ECL signal centered at 455 nm, which is well matched with the adsorption of GPRu?Au, thereby a high efficient electrochemiluminescent resonance energy transfer (ECL?RET) sensing platform is designed. AuNPs facilitate the immobilization of antibody on the nanomaterials through Au?N bond. The high surface area of graphene oxide/polyethyleneimine allows a large number of Ru(dcbpy)3 2+ to be loaded, which immensely amplify the ECL signal. This sensing platform exhibits outstanding analytical performance toward cTnI with a detection limit of 3.94 fg/mL (S/N=3). The high reliability, selectivity and sensitivity of this ratiometric ECL biosensor provides a versatile sensing platform for the bioanalysis.
关键词： carbon nitride nanosheets,ECL biosensor,graphene oxide,Ratiometric electrochemiluminescence,cardiac troponin I,Au nanoparticles
更新于2025-09-04 15:30:14