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Recent advances of plasmonic nanoparticle-based optical analysis in homogeneous solution and at the single-nanoparticle level
摘要: Plasmonic nanoparticles with special localized surface plasmon resonance (LSPR) characters have been widely applied for optical sensing of various targets. With the combination of single nanoparticle imaging techniques, dynamic information of reactions and biological processes is obtained, facilitating the deep understanding of their principle and design of outstanding nanomaterials. In this review, we summarize the recently adopted optical analysis of diverse analytes based on plasmonic nanoparticles in both homogeneous solution and single-nanoparticle level. A brief introduction of LSPR is first discussed. Colorimetric and fluorimetric homogeneous detection examples by using different sensing mechanisms and strategies are provided. Single plasmonic nanoparticle-based analysis is concluded in two aspects: visualization of chemical reactions and understanding of biological processes. The basic sensing mechanisms and performances of these systems are introduced. Finally, this review highlights the challenges and future trend of plasmonic nanoparticle-based optical analysis system.
关键词: Plasmonic nanoparticles,Single-nanoparticle level,Fluorimetric assays,Chemical reactions,Localized surface plasmon resonance (LSPR),Optical analysis,Homogeneous solution,Colorimetric assays,Biological processes
更新于2025-09-23 15:21:01
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Colorimetric detection of solution concentration based on a paper-based microfluidic device
摘要: A new method for colorimetric detection of solution concentration is presented. A paper-based micro?uidic device was designed and made using printed circuit board technology. Detection zone patterns were designed and transferred to a printed circuit board by hollowing technology. The printed circuit board with patterns was stuck onto a copper sheet. The hollowed zone was ?lled with solid para?n and then covered with a piece of ?lter paper. The para?n wax was melted by heating the copper sheet and permeated into the ?lter paper. Solution to be detected was pipetted on the paper-based device with detective zones. The images of the detective zones were obtained using a microscope with charge-coupled device, which is used for calculating RGBI model to further obtain the solution concentration. Litmus was demonstrated in sample experiments. Results showed that maximum error of measured value of solution concentration to its true value is less than 2% using the presented method.
关键词: concentration,detective zone,Paper-based device,colorimetric assays
更新于2025-09-09 09:28:46