Enantioselective ?±-Allylation of Anilines Enabled by a Combined Palladium and Photoredox Catalytic System

摘要： An enantioselective and branch-regioselective α-allylation of N-methyl anilines under dual palladium/photoredox catalysis is described. Readily available N-methyl anilines are used as formal “hard” alkyl nucleophiles without pre-activation. Acetic acid is the only side product, which leads to high atom economy of this reaction. This protocol shows good functional group tolerance and broad scope. A range of chiral homoallylic amines were prepared in moderate to good yields (up to 76%), excellent regio- (B:L > 95:5 in all cases) and enantioselectivities (up to 96% ee) under mild reaction conditions.