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Tetramodal Imaging and Synergistic Cancer Radio-Chemotherapy Enabled by Multiple Component-Encapsulated Zeolitic Imidazolate Frameworks
摘要： The abundant species of functional nanomaterials have attracted tremendous interests as components to construct multifunctional composites for cancer theranostics. However, their distinct chemical properties substantially require a specific strategy to integrate them in harmony. Here, we report the preparation of a distinctive multifunctional composite by encapsulating small-sized semiconducting copper bismuth sulfide (CBS) nanoparticles and rare-earth down-conversion (DC) nanoparticles in larger-sized zeolitic imidazolate framework-8 (ZIF8) nanoparticles, followed by loading an anticancer drug, doxorubicin (DOX). Such composites can be used for tetramodal imaging, including traditional computed tomography and magnetic resonance imaging and, recently, for photoacoustic imaging and fluorescence imaging. With a pH-responsive release of the encapsulated components, synergistic radio-chemotherapy with a high (87.6%) tumor inhibition efficiency is achieved at moderate doses of the CBS&DC-ZIF8@DOX composite with X-ray irradiation. This promising strategy highlights the extending capacity of zeolitic imidazolate frameworks to encapsulate multiple distinct components for enhanced cancer imaging and therapy.
关键词： multifunctional,zeolitic imidazolate frameworks,tetramodal imaging,multiple encapsulation,synergistic radio-chemotherapy
更新于2025-11-14 15:24:45
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A New Biscarbazole-Based Metal-Organic Framework for Efficient Host-Guest Energy Transfer
摘要： A new metal–organic framework (MOF), [Zn6L4(Me2NH2+)4·3 H2O] (1) was constructed based on [9,9’-biscarbazole]-3,3’,6,6’-tetracarboxylic acid (H4L) and Zn2+ ions. The porous framework and intense blue fluorescence of the MOF based on the biscarbazole moiety of the ligand could facilitate efficient host to guest energy transfer, which makes it an ideal platform for the tuning of luminescence.
关键词： in situ encapsulation,metal–organic frameworks,energy transfer,host–guest systems,fluorescence
更新于2025-09-23 15:23:52
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Ethanol-Precipitable Silica-Passivated Perovskite Nanocrystals Incorporated into Polystyrene Microspheres for Long-Term Storage and Re-Usage
摘要： Perovskite nanocrystals (PNCs) are emerging luminescent materials due to their fascinating physic-optical properties. However, their sensitive surface chemistry with organic polar solvents, oxygen and moisture greatly hinders their developments towards practical applications. Herein we promote silica-passivated PNCs (SP-PNCs) by in situ hydrolyzing the surface ligands of (3-aminopropyl) triethoxysilane. The resultant SP-PNCs possesses a high quantum yield (QY) of 80% and are precipitable by polar solvents, such as ethanol and acetone, without destroying their surface chemistry or losing QY, which offers an eco-friendly and efficient method for separation, purification and phase transfer of PNCs compared with the traditional solvent evaporation technique. Moreover, we further promoted a swelling-deswelling encapsulation process to incorporate the as-made SP-PNCs into polystyrene microspheres (PMs), which can largely increase the stability of the SP-PNCs against moisture for long-term storage. Besides, the embedded SP-PNCs can also be reused and mono-dispersed by totally dissolving the PMs in suitable solvents for making all-solution-processed devices. We thereby believe this work should open new avenues for greener synthesis, scalable production, and long-term storage of PNCs towards the emerging practical applications.
关键词： stability,perovskite nanocrystals,surface engineering,encapsulation,polar environment
更新于2025-09-23 15:23:52
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Water-Stable Metal–Organic Frameworks with Selective Sensing on Fe <sup>3+</sup> and Nitroaromatic Explosives, and Stimuli-Responsive Luminescence on Lanthanide Encapsulation
摘要： Three water-stable luminescent MOFs [Zn4(bptc)2(NMP)3(DMF)(H2O)2]n (1-a), [Cd4(bptc)2(NMP)3(DMF)2(H2O)1]n (1-b), and {[Zn2(bptc)(DMA)(H2O)2]·(DMA)2·H2O}n (2), possessing similar chemical components (M2:L1:Sol3) and topology structures, were synthesized by solvents control. Their excellent sensing on iron(III) cation and nitroaromatic explosives (NACs) with great selectivity, sensitivity and a high Ksv (4.54 × 10^4 for 1-b on PNP) were observed by quenching effects. Furthermore, Zn-MOFs exhibit interesting stimuli-responsive luminescence enhancement after the encapsulation of a series of IIIB cations stimulated different luminescent emitting and intensity enhancement through host–guest processes of the pores in MOFs, especially for two distinct responses of Zn-MOF on a Tb3+ cation.
关键词： stimuli-responsive,nitroaromatic explosives,luminescent,water-stable,lanthanide encapsulation,iron(III),metal-organic frameworks,sensing
更新于2025-09-23 15:23:52
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Highly stable all-inorganic CsPbBr <sub/>3</sub> nanocrystals film encapsulated with alumina by plasma-enhanced atomic layer deposition
摘要： All-inorganic CsPbBr3 nanocrystals (NCs) have been considered as promising candidates for many optoelectronic applications. However, their perspectives are primarily impeded by the material instability arising from the labile surface and ionic nature of CsPbBr3 NCs. Hence it is high desired to obtain robust CsPbBr3 NCs film for practical applications. Herein, we deposited Al2O3 on NCs film surface for film stabilization by plasma-enhanced atomic layer deposition. The dense Al2O3 film can yield an excellent encapsulation effect, leading to a dramatically improved stability of CsPbBr3 NCs film. This work not only provides a superior technique for NCs film coating but also contributes to address the stability issue of CsPbBr3 NCs.
关键词： PEALD,Encapsulation,Inorganic Materials,Stability,CsPbBr3 Nanocrystals
更新于2025-09-23 15:22:29
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Examination of dielectric strength of thin Parylene C films under various conditions
摘要： The breakdown voltage of the biocompatible polymer Parylene C was determined after storage in 60°C saline solution and treatment by autoclave. It occurred that both, storage at 60°C in saline solution and autoclaving, lead to distinct decrease of dielectric strength by approximately 50%.
关键词： Parylene C,dielectric strength,insulation,encapsulation,implant
更新于2025-09-23 15:22:29
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Mechanisms of adhesion degradation at the photovoltiac module's cell metallization-encapsulant interface
摘要： Adhesion measurements and chemical characterization of the encapsulant/silver metallization interface of a photovoltaic (PV) module through temperature, humidity, and voltage bias exposures were conducted. Results demonstrate two independent degradation mechanisms: (a) with voltage bias, the ionic conduction of Na+ ions through the encapsulant results in the formation of sodium silicate at the silver metallization surface, thereby weakening that interface and (b) with moisture ingress, dissociation of the silane bonding to silver in the silver oxide similarly weakens this interface resulting in significantly lower debond energies.
关键词： photovoltaic module,screen printing,reliability,encapsulation,degradation,metallization
更新于2025-09-23 15:22:29
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Effects of Trapped Charges in Gate Dielectric and High-k Encapsulation on Performance of MoS? Transistor
摘要： The effects of trapped charges in gate dielectric and high-k encapsulation layer on the performance of MoS2 transistor are investigated by using SiO2 with different thicknesses as the gate dielectric and HfO2 as the encapsulation layer of the MoS2 surface. Results indicate that the positive trapped charges in SiO2 can increase the electrons in MoS2 for screening the scattering of charged impurity (CI) in SiO2 and at the SiO2/MoS2 interface to increase the carrier mobility. However, the CI scattering becomes stronger for thicker gate dielectric with more trapped charges and can dominate the electron screening effect to reduce the mobility. On the other hand, with the HfO2 encapsulation, the OFF-currents of the devices greatly increase and their threshold voltages shift negatively due to more electrons induced by more positive charges trapped in HfO2. Moreover, the screening effect of these electrons on the CI scattering results in a mobility increase, which increases with the magnitude of the CI scattering. A 51% improvement in mobility is obtained for the sample suffering from the strongest CI scattering, fully demonstrating the effective screening role of high-k dielectric on the CI scattering.
关键词： Charged impurity (CI) scattering,mobility,high-k encapsulation,trapped charges,MoS2 FET
更新于2025-09-23 15:22:29
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Surface Planarization of Low-Temperature Flowable Silicon Oxide for Atomic Layer Deposition Al <sub/>2</sub> O <sub/>3</sub> Thin Film Encapsulation
摘要： In this research, a flowable chemical vapor deposition (FCVD) process was developed to planarize particle-scattered surfaces for thin film encapsulation by atomic layer deposition (ALD). Nanometer-thick ALD layers are known to have good barrier properties owing to the conformal deposition of the films and their high density, but those barrier properties are vulnerable to degradation because of surface particles on the substrates. In this study, FCVD silicon oxide layer was applied to particle-scattered surfaces as a planarization interlayer. Flowable silicon oxide thin films were deposited with tetrabutoxysilane and O2 in an inductively coupled plasmas reactor. The chemical bonding structure of the flowable silicon oxide was verified with Fourier transform infrared spectroscopy. To confirm the planarization effect, particles 2 μm in diameter were intentionally spread on the substrates by electrospray processing and nanometer-thick Al2O3 layers were deposited on top of the planarization interlayers. With the flowable silicon oxide interlayer and the same particle density on flexible substrates, the water vapor transmission rate was reduced to 1.2 × 10?3 g/(m2 · day) from 2.0 × 10?3 g/(m2 · day). The flowable silicon oxide layers are thus demonstrated to be effective interlayers to reduce the influence of particle contamination for ALD barrier films.
关键词： Thin Film Encapsulation,Planarization Effect,Flowable Chemical Vapor Deposition
更新于2025-09-23 15:22:29
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Development of low cost packaged fibre optic sensors for use in reinforced concrete structures
摘要： There is an ongoing need to measure strains in reinforced concrete structures more reliably and under a range of circumstances e.g. long term durability (such as effects of cracking and reinforcement corrosion), response to normal working loads and response under abnormal load conditions. Fibre optic sensors have considerable potential for this purpose and have the additional advantages, including of immunity to electromagnetic interference and light weight (Grattan et al, 2000). This is important in railway scenarios and particularly so when the lines are electrified. Their small size allows for easy installation. However, their use as commercial ‘packaged’ devices (traditionally seen as necessary to achieve adequate robustness) is limited by their high cost relative to other sensor devices such as encapsulated electric resistance strain gauges. This paper describes preliminary work to produce a cost-effective and easy-to-use technique for encapsulating fibre optic sensors in resin using 3D printing techniques to produce a robust, inexpensive ‘packaged’ sensor system suitable for use with concrete structures. The work done to date has shown this to be a convenient and economical way of producing multiple sensors which were suitable for both surface mounting and embedment in reinforced concrete structures. The proof-of-concept testing to which the trial packages were subjected is described in the paper and the results indicate that 3D printed packages have considerable potential for further development and use in a variety of civil engineering applications, competing well with more conventional sensor systems.
关键词： encapsulation,reinforced concrete,3D printing,Fibre optic sensor,strain measurement
更新于2025-09-23 15:21:21