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Quantitative analysis of radiation dosage and image quality between digital breast tomosynthesis (DBT) with two-dimensional synthetic mammography and full-field digital mammography (FFDM)
摘要： Purpose: Currently in diagnostic setting for breast cancer, FFDM and DBT are performed conjunctively. However, performing two imaging modalities may increase radiation exposure by double. Two-dimensional reconstructed images created from DBT with 2DSM, has a potential to replace conventional FFDM in concerning both radiation dosage and image quality. With increasing concerns for individual radiation exposure, studies analyzing radiation dosage in breast imaging modalities are needed. This study compared radiation dosage and image quality between DBT + 2DSM versus FFDM. Methods and materials: 374 patients (mean age 52 years) who underwent both DBT and FFDM were retrospectively reviewed. Radiation dosage data were obtained by radiation dosage scoring and monitoring program Radimetrics (Bayer HealthCare, Whippany, NJ). Entrance dose and mean glandular doses in each breast were obtained for both modalities. To compare image quality of DBT + 2DSM and FFDM, a 5-point scoring system for lesion clarity was assessed. The parameters of radiation dosage (entrance dose, mean glandular dose) and image quality (lesion clarity scoring) were compared. Results: For entrance dose, DBT had lower mean dosage (14.8 mGy) compared with FFDM (21.8 mGy, p-value < 0.0001). Mean glandular doses for both breasts were lower in DBT (Left 1.74, Right 2.1) compared with FFDM (Left 2.85, Right 2.74, p-value < 0.0001). Lesion clarity score was higher in DBT with 2DSM (mean score 4.03) compared with FFDM (3.82, p-value < 0.0001). Conclusion: DBT showed lower radiation entrance dose and mean glandular doses to both breasts compared with FFDM. DBT + 2DSM had better image quality than FFDM, suggesting that DBT with 2DSM has potential as an alternative to FFDM.
关键词： Radimetrics,Full-field digital mammography,Image quality,2-Dimensional synthetic mammography,Digital breast tomosynthesis,Radiation dose
更新于2025-09-19 17:15:36
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PACS-Based Multimedia Imaging Informatics (Basic Principles and Applications) || Digital Medical Imaging
摘要： The chapter discusses the fundamentals of digital medical imaging, including two-dimensional (2-D) and three-dimensional (3-D) imaging techniques, image compression, and the integration of imaging informatics with patient imaging workflows. It covers various imaging modalities such as computed radiography (CR), digital mammography, nuclear medicine imaging, ultrasound imaging, and magnetic resonance imaging (MRI), highlighting their principles, applications, and the challenges in archiving and transmitting large datasets.
关键词： digital medical imaging,computed radiography,ultrasound imaging,digital mammography,PACS,2-D imaging,image compression,3-D imaging,nuclear medicine imaging,magnetic resonance imaging
更新于2025-09-10 09:29:36
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Performance evaluation of total variation (TV) denoising technique for dual-energy contrast-enhanced digital mammography (CEDM) with photon counting detector (PCD): Monte Carlo simulation study
摘要： The dual-energy contrast-enhanced digital mammography (CEDM) system based on a photon counting detector (PCD) is very useful providing functional information for breast cancer detection. In particular, this system can be used to solve the spectral overlap and high radiation dose problems. However, imaging noise is a big problem because of the degradation image performance and cancer detection ratio in the CEDM system. To address this problem, a total variation (TV)-based denoising technique approach has recently been studied. Thus, the aim of this study was to evaluate and confirm the image performance of our TV-based denoising technique with dual-energy CEDM with a PCD. For this purpose, we simulated a dual-energy CEDM with a PCD and breast phantom in Monte Carlo simulation using the Geant4 Application for Tomographic Emission (GATE) that is an essential open source program. We also designed a TV-based denoising technique based on the L1-norm estimation included correction and iteration steps for acquiring high edge preservation in X-ray images. To evaluate the image performance, we used evaluation parameters with a contrast-to-noise ratio (CNR) and coefficient of variation (COV) as a function of the absorbed dose levels (2.18, 1.53, 1.09, and 0.66 mGy). According to the results, the average of all iodine thicknesses and absorbed dose conditions for the CNR using our proposed TV-based denoising technique was 1.71, 1.39, and 1.13 times higher than that acquired for the noisy image, median filter and Wiener filter, respectively. We also acquired excellent COV results for the dual-energy CEDM with a PCD system (2.53 times higher than that of the noisy image). In conclusion, the results of this study suggested that a TV-based denoising technique can be achieved with an improved image performance and the effect and feasibility of the TV-based denoising technique for dual-energy CEDM with a PCD can be investigated.
关键词： Dual-energy imaging method,Monte Carlo simulation,Total variation (TV)-based denoising technique,Photon counting detector (PCD),Evaluation of image performance,Contrast-enhanced digital mammography (CEDM)
更新于2025-09-10 09:29:36
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Comparison of Digital Breast Tomosynthesis (DBT) and Digital Mammography (DM) for Detection of Breast Cancer in Women in Kuwait
摘要： Objective: To investigate the sensitivity and specificity of digital mammography (DM) and digital breast tomosynthesis (DBT) for the detection of breast cancer in comparison to histopathology findings. Subjects and Methods: We included 65 breast lesions in 58 women, each detected by two diagnostic mammography techniques: DM and DBT using Senographe Essential machine (GE Healthcare, Buc, France), and subsequently confirmed by histopathology. The Breast Imaging-Reporting and Data System (BI-RADS) was used for characterizing the lesions. Results: The average age of women was 48.3 years (range; 26-81 years). There were 34 malignant and 31 benign breast lesions. The sensitivity for DM and DBT, was 73.5% and 100%, respectively, while the specificity was 67.7% and 94%, respectively. Receiver-operating characteristic curve analysis showed an overall diagnostic advantage of DBT over DM, with significant a difference between DBT and DM (p < 0.001). By performing Cohen’s kappa test, we found that there was a strong level of agreement according to Altman guidelines between DBT and histopathology findings (0.97), but there was weak agreement between DM and histopathology findings (0.47). Conclusion: DBT improves the clinical accuracy of mammography by increasing both sensitivity and specificity. We believe this improvement is due to improved image visibility and quality. These results could be of interest to health care institutions as it may impact their decision on whether to upgrade to DBT not only for diagnosis but also for screening.
关键词： Digital breast tomosynthesis,Digital mammography,Histopathology,Breast cancer
更新于2025-09-09 09:28:46