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Micro/nano processing of natural silk fibers with near-field enhanced ultrafast laser; ?????¨è????o?￠???oè????????????ˉ1?¤????è?????è??è??????o3????·￥;
摘要： Silkworm silk fiber is an attractive material owing to its remarkable mechanical characteristics, excellent optical properties, and good biocompatibility and biodegradability. However, nano-processing of the silk fiber is still a challenge limiting its applications in nanoengineering and related fields. Herein, we report localized near-field enhancement-assisted ablation with an ultrafast laser to break this bottleneck. Localized processing of silk fiber, including nano-holing, nano-grooving, and cutting could retain the key molecular structure building blocks and the pristine functionality of the silk fiber. An extremely narrow nanohole with a width of ~64 nm was successfully achieved. The processed silk fiber can be used to transfer micro/nanoparticles and drugs, showing potential for biomedical engineering. The processing strategy developed in this study can also be extended to other materials, paving a new way for fabricating functional nanostructures with precisely controlled size and morphology.
关键词： nano-processing,ultrafast laser,drug delivery,silk fiber,laser ablation
更新于2025-09-23 15:21:01
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Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells
摘要： Aim: To synthesize and examine the impact of free Eudragit R(cid:2) RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV–Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.
关键词： quantum dots,curcumin,antibacterial agent,drug delivery,anticancer agent
更新于2025-09-23 15:21:01
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Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatial/temporal-controlled drug release triggered by NIR laser irradiation
摘要： Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in remote-controlled release of anticancer drugs. Herein we report a novel NIR light responsive composite hydrogel system that undergoes structural changes to realize drug delivery and precise release, which are constructed by poly (N-isopropylacrylamide) network and photothermal agent 4OCSPC/F127 micelles.
关键词： PNIPAM,NIR light-responsive hydrogels,4OCSPC/F127 micelles,drug delivery,photothermal agent
更新于2025-09-23 15:21:01
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Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells
摘要： Nanotechnology employs multifunctional engineered materials in the nanoscale range that provides many opportunities for translational stem cell research and therapy. Here, a cell-penetrating peptide (virus-1 transactivator of transcription)–conjugated, porous silicon nanoparticle (TPSi NP) loaded with the Wnt3a protein to increase both the cell survival rate and the delivery precision of stem cell transplantation via a combinational theranostic strategy is presented. The TPSi NP with a pore size of 10.7 nm and inorganic framework enables high-efficiency loading of Wnt3a, prolongs Wnt3a release, and increases antioxidative stress activity in the labeled mesenchymal stem cells (MSCs), which are highly beneficial properties for cell protection in stem cell therapy for myocardial infarction. It is confirmed that the intracellular aggregation of TPSi NPs can highly amplify the acoustic scattering of the labeled MSCs, resulting in a 2.3-fold increase in the ultrasound (US) signal compared with that of unlabeled MSCs. The translational potential of the designed nanoagent for real-time US imaging–guided stem cell transplantation is confirmed via intramyocardial injection of labeled MSCs in a nude mouse model. It is proposed that the intracellular aggregation of protein drug–loaded TPSi NPs could be a simple but robust strategy for improving the therapeutic effect of stem cell therapy.
关键词： drug delivery,porous silicon,ultrasound imaging,cell protection,cell labeling
更新于2025-09-23 15:21:01
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Site Selective Nucleation and Size Control of Gold Nanoparticle Photothermal Antennae on the Pore Structures of a Virus
摘要： In this article, we show that the surface of the bacteriophage Qβ is equipped with natural ligands for the synthesis of small gold nanoparticles. By exploiting disulfides in the protein secondary structure and the geometry formed from the capsid quaternary structure, we find we can produce regularly arrayed patterns of ~6 nm gold nanoparticles across the surface of the virus-like particle. Experimental and computational analysis provide insight into the formation and stability of this composite. We further show that the entrapped genetic material can hold upwards of 500 molecules of the anti-cancer drug Doxorubicin without leaking and without interfering with the synthesis of the gold nanoparticles. This direct nucleation of nanoparticles on the capsid allows for exceptional conduction of photothermal energy upon nanosecond laser irradiation. As a proof of principle, we demonstrate that this energy is capable of rapidly releasing the drug from the capsid without heating the bulk solution, allowing for highly targeted cell killing in vitro.
关键词： Drug Delivery,Virus-Like Particles,Gold Nanoparticles,Photothermal Release
更新于2025-09-23 15:21:01
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Photoactive Functional Soft Materials (Preparation, Properties, and Applications) || Soft Materials Driven by Photothermal Effect and Their Applications
摘要： We are surrounded by soft materials. Most organs of the human body are made of soft materials. One defining characteristic of soft materials is that they can be readily deformed by external stimuli and stress. Even the thermal energy available at room temperature is sufficient to cause significant deformation in soft materials. de Gennes in his 1991 Nobel lecture emphasized “flexibility” as a defining characteristic of soft materials. Colloids, polymers, liquid crystals (LCs), gels, and biological materials are categorized as soft materials. Being pervasive in nature, soft materials have been a source of inspiration for scientists and engineers for the design and fabrication of stimuli‐responsive smart materials and systems for scientific investigations to understand the basic principles and technological application in devices and health care. Accordingly, a wide variety of engineered soft materials have been developed, which play a crucial role in modern technology. Soft nanotechnology, soft robotics, and soft lithography are examples that reflect the far‐reaching implications of soft materials in biology and engineering. Soft materials constitute one of the most stimulating interdisciplinary frontiers of modern science and are built on diverse experimental and theoretical foundations. Although soft materials in neat state have found a wide range of applications, fabrication of composites of soft materials by integrating other functional materials has recently become a common practice to realize advanced and tunable materials with enhanced properties for high‐tech applications. Incorporation of photothermal agents into the matrices of soft materials is one such emerging approach.
关键词： nanocomposites,soft materials,liquid crystals,photothermal therapy,polymers,gels,photothermal effect,actuators,drug delivery
更新于2025-09-23 15:21:01
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Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin
摘要： Upconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostics). In the present work, we report microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica and functionalized with amine (UCNP@mSiO2). The UCNP@mSiO2 were investigated for controlled delivery of a chemotherapeutic agent, doxorubicin (DOX, hydrophilic), and a chemosensitizing agent, curcumin (CCM, hydrophobic). The drug loading was relatively higher for DOX (17.4%), in comparison to CCM (8.1%). The cumulative drug release from DOX-loaded UCNP@mSiO2 were 30 and 41% at physiological (7.4) and tumoral (6.4) pH, following a pseudo Fickian release pattern, whereas the release from CCM-loaded UCNP@mSiO2 were 27 and 50% at pH 7.4 and 6.4, following a non-Fickian and pseudo-Fickian release patterns. Both DOX and CCM-loaded UCNP@mSiO2 exhibited pH-dependent controlled drug delivery but the effect was more pronounced for CCM, the hydrophobic chemosensitizer. Cell viability assay using HeLa cells showed that DOX-loaded UCNP@mSiO2 inhibit cell growth in a dose-dependent manner, similar to free DOX, but the cell inhibition activity of free CCM was lower than CCM passively entrapped in UCNP@mSiO2. Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells. Thus, UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs, individually. UCNP@mSiO2 carrier, equipped with theranostic capabilities, may potentially be used for pH-responsive release of chemotherapeutic agents in cancer environment.
关键词： curcumin,porous silica,doxorubicin,drug delivery,Upconversion nanoparticles
更新于2025-09-23 15:21:01
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[Springer Series on Polymer and Composite Materials] Polymer/POSS Nanocomposites and Hybrid Materials (Preparation, Properties, Applications) || POSS Hybrid Materials for Medical Applications
摘要： Medical application is one of the most important issues in the field of material science and has found very high level of attention. During the last decades, the development of new methods or materials which can improve the quality of medical services has been very intense. Using nanotechnology provides new rooms to enhance this field. Polyhedral oligomeric silsesquioxane (POSS) is a new generation of nanostructures showing the properties of nanoparticles and molecules at the same time. Improving thermal and mechanical properties and enhanced solubility are interesting characteristics found in these materials. POSS can be used in medical applications, broadly. It can improve mechanical properties of biomaterials that are very important in tissue engineering. Also, it can improve the resistance of biomaterials against degradation. Today, dental materials use POSS as a key component. Drug delivery and bioimaging are other examples that use POSS as discussed in this chapter.
关键词： POSS,Dental nanocomposite,Bioimaging,Biomaterial,Drug delivery,Tissue engineering
更新于2025-09-23 15:21:01
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Prerequisites and prospects for the development of novel systems based on the Keplerate type polyoxomolybdates for the controlled release of drugs and fluorescent molecules
摘要： Synthetic approaches were proposed to the development of hybrid organic—inorganic systems based on giant Keplerate polyoxometalates (POM Мо132), biocompatible polymers, and fluorescent molecules. A concept was formulated for the production of new systems for the prolonged release of drugs bearing a constant or temporary (protonated group) positive charge and fluorescent labels for tissue staining during electrophoretic introduction. In particular, a possibility of covalent functionalization of the POM Мо132 surface by the organosilicon molecules (aminopropyltrimethoxysilane) was shown. A promising procedure of the synthesis of NHS-esters of rhodamine B for the subsequent inclusion into the hybrid system was developed. The kinetic studies of POM destruction in an aqueous medium were carried out. The influence of association of rhodamine B with Мо132 on the character of fluorescence was studied.
关键词： organosilicon compounds,prolonged release,releasing,drug delivery systems,fluorescence,polyoxomolybdates
更新于2025-09-23 15:19:57
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Cisplatin-Loaded Polymeric Micelles with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy
摘要： Imaging-guided disease theranostic nanoplatforms based on polymeric micelles have drawn a broad attention because of their clear visualization, reduced systemic toxicity, enhanced utilization of drugs, and suppressed chemoresistance of tumors, which makes them possess potential application for cancer therapy. Herein, we synthesized a polymeric nanoparticles (Poly (MAD-alt-OCE)-PTZ-PEG) with novel aggregation-induced emission (AIE) characteristic based on cheap commercial polymer by the simple and environmental method. These Poly(MAD-alt-OCE)-PTZ-PEG nanoparticles (NPs) show excellent biocompatibility and fluorescence property, which makes them huge application potential for cellular imaging. Furthermore, the antitumor drug cisplatin Pt(IV) can be loaded efficiently onto the surface of Poly(MAD-alt-OCE)-PTZ-PEG NPs due to the existence of abundant carboxyl groups on the NPs surface. The well-controlled Pt(IV)-loaded yield and great acid-responsive drug release of these polymeric micelles enhance cytotoxicity against cancer cells in vitro. Given the cheap raw materials, eco-friendly method, excellent AIE property, efficient antitumor drug delivery and pH-controlled drug release, these polymeric NPs would be a potential candidate for cancer diagnosis and therapy in the future.
关键词： Aggregation-induced emission,Drug delivery,Cellular imaging,Polymeric nanoparticles
更新于2025-09-23 15:19:57