Blood Flow in Monocular Retinoblastoma Assessed by Color Doppler and Correlations With High-Risk Pathologic Features

摘要： PURPOSE. To use color Doppler to analyze blood ?ow in the retrobulbar central retinal artery (CRA) and central retinal vein (CRV) in monocular retinoblastoma. METHODS. This prospective study included patients with group D and E retinoblastomas managed with only enucleation. Peak blood velocities were assessed in the CRA and CRV of tumor-containing eyes (CRAv and CRVv, respectively). The resistivity index in the CRA (RIa) and pulse index in the CRV (PIv) were calculated and related to optic nerve invasion (ONi), choroid invasion (mCHi), and tumor volume. RIa and PIv were also calculated for healthy eyes. RESULTS. In total, 25 patients with a mean age of 30.8-months old were included. The means (SD) for CRAv, CRVv, RIa, and PIv were 26.94 (12.32) cm/s, 16.2 (9.56) cm/s, 0.88 (0.12) and 0.79 (0.29), respectively. Tumor volume was signi?cantly correlated with CRAv (P ? 0.025) and RIa (P ? 0.032). ONi was present in 19 eyes and correlated with a smaller PIv (P < 0.001). A PIv less than 0.935 had a sensitivity of 89.5% and speci?city of 83.3% for predicting ONi. mCHi was not correlated with ?ow values. Healthy eyes had a signi?cantly lower RIa (P < 0.001) and lower PIv than eyes with (P ? 0.009) and without (P < 0.001) ONi. tumor volume was directly CONCLUSIONS. correlated with CRAv and RIa, and lower PIv was correlated with optic nerve invasion when a predictive cut-off value of less than 0.935 was applied. Comparisons with healthy eyes showed that tumor-containing eyes were associated with higher RIa and PIv values.