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Predictors affecting myopic regression in ??6.0D to ??10.0D myopia after laser-assisted subepithelial keratomileusis and laser in situ keratomileusis flap creation with femtosecond laser-assisted or mechanical microkeratome-assisted
摘要： Purpose To investigate the predictive factors of postoperative myopic regression among subjects who have undergone laser-assisted subepithelial keratomileusis (LASEK), laser-assisted in situ keratomileusis (LASIK) flap created with a mechanical microkeratome (MM), and LASIK flap created with a femtosecond laser (FS). All recruited patients had a manifest spherical equivalence (SE) from - 6.0D to - 10.0D myopia. Methods This retrospective, observational case series study analyzed outcomes of refraction at 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. Predictors affecting myopic regression and other covariates were estimated with the Cox proportional hazards model for the three types of surgeries. Results The study enrolled 496 eyes in the LASEK group, 1054 eyes in the FS-LASIK group, and 910 eyes in the MM-LASIK group. At 12 months, from - 6.0D to - 10.0D myopia showed that the survival rates (no myopic regression) were 52.19%, 59.12%, and 58.79% in the MM-LASIK, FS-LASIK, and LASEK groups, respectively. Risk factors for myopic regression included thicker postoperative central corneal thickness (P ^ 0.01), older age (P ^ 0.01), aspherical ablation (P = 0.02), and larger transitional zone (TZ) (P = 0.03). Steeper corneal curvature (Kmax) (P = 0.01), thicker preoperative central corneal thickness (P < 0.01), smaller preoperative myopia (P < 0.01), longer duration of myopia (P = 0.02), with contact lens (P < 0.01), and larger optical zone (OZ) (P = 0.02) were protective factors. Among the three groups, the MM-LASIK had the highest risk of postoperative myopic regression (P < 0.01). Conclusions The MM-LASIK group experienced the highest myopic regression, followed by the FS-LASIK and LASEK groups. Older age, aspheric ablation used, thicker postoperative central corneal thickness, and enlarging TZ contribute to myopic regression; steeper preoperative corneal curvature (Kmax), longer duration of myopia, with contact lens, thicker preoperative central corneal thickness, lower manifest refraction SE, and enlarging OZ prevent postoperative myopic regression in myopia from - 6.0D to - 10.0D.
关键词： Myopic regression,Laser-assisted subepithelial keratomileusis,Mechanical microkeratome,Laser in situ keratomileusis,Femtosecond laser
更新于2025-09-16 10:30:52
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An experimental investigation of laser drilling nitrile butadine (NBR) rubber
摘要： This paper focusses on understanding laser-NBR rubber interactions in particular the effect of laser wavelength and pulse width on material removal and thermal damage. Three lasers with wavelengths at 355 nm, 795 nm and 1064 nm and pulse duration at 30 ns, 10 ps and 130 fs, respectively, have been investigated for their optical absorption, heat conduction and their material removal mechanisms in high aspect ratio drilling of NBR rubber. It is interesting to find that under certain conditions, the ultrashort pulse lasers (both the femtosecond and picosecond lasers) did not lead to better results than the nanosecond UV laser in drilling hole profile (straightness and thermal damage), aspect ratio and amount of the ablated material re-deposition on the substrate surfaces. The results implied that there is heat conduction and thermal damage even with ultrashort laser pulses when the processing conditions are not appropriate. Firing laser pulses intermittently was shown to reduce thermal accumulation. Experimental studies showed that the 355-nm Nd:YAG laser (UV laser) achieved higher material removal rate with high aspect ratio as compared to the ultrashort laser pulses in drilling the NBR substrates.
关键词： NBR rubber,Pulse width effect,Picosecond laser drilling,UV laser drilling,Femtosecond laser drilling
更新于2025-09-16 10:30:52
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Numerical Investigation of Ultrashort Laser-Ablative Synthesis of Metal Nanoparticles in Liquids Using the Atomistic-Continuum Model
摘要： We present a framework based on the atomistic continuum model, combining the Molecular Dynamics (MD) and Two Temperature Model (TTM) approaches, to characterize the growth of metal nanoparticles (NPs) under ultrashort laser ablation from a solid target in water ambient. The model is capable of addressing the kinetics of fast non-equilibrium laser-induced phase transition processes at atomic resolution, while in continuum it accounts for the effect of free carriers, playing a determinant role during short laser pulse interaction processes with metals. The results of our simulations clarify possible mechanisms, which can be responsible for the observed experimental data, including the presence of two populations of NPs, having a small (5–15 nm) and larger (tens of nm) mean size. The formed NPs are of importance for a variety of applications in energy, catalysis and healthcare.
关键词： metal nanoparticles,femtosecond laser ablation,dual nanoparticle distribution,pulsed laser ablation in liquids
更新于2025-09-16 10:30:52
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Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing
摘要： We report an easy-to-implement device for surface-enhanced Raman scattering (SERS)-based detection of various analytes dissolved in water droplets at trace concentrations. The device combines an analyte-enrichment system and SERS-active sensor site, both produced via inexpensive and high-performance direct femtosecond (fs)-laser printing. Fabricated on a surface of water-repellent polytetrafluoroethylene substrate as an arrangement of micropillars, the analyte-enrichment system supports evaporating water droplet in the Cassie–Baxter superhydrophobic state, thus ensuring delivery of the dissolved analyte molecules towards the hydrophilic SERS-active site. The efficient pre-concentration of the analyte onto the sensor site based on densely arranged spiky plasmonic nanotextures results in its subsequent label-free identification by means of SERS spectroscopy. Using the proposed device, we demonstrate reliable SERS-based fingerprinting of various analytes, including common organic dyes and medical drugs at ppb concentrations. The proposed device is believed to find applications in various areas, including label-free environmental monitoring, medical diagnostics, and forensics.
关键词： SERS,direct laser processing,femtosecond laser pulses,medical drugs,superhydrophobic textures,plasmonic nanostructures,analyte enrichment
更新于2025-09-16 10:30:52
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Efficient Selective Dismantlement of Protoplast Cell with Femtosecond Laser
摘要： We made the protoplast cell of red cabbage. And we irradiated to the protoplast cell with a continues-wave laser. It was impossible to break down the protoplast cell. On the other hand, we used the slide evaporated gold thin film, it was possible to break down a few protoplast cell. We used the femtosecond laser, it was possible to break down almost protoplast cell. The femtosecond laser used in our experiment was mode-locked fiber ring laser. It also had a 300fs pulse width, 52kW peak power, and 4.773MHz pulse repetition frequency. Experimental results verified that it was possible to break down the protoplast cell on an electrode.
关键词： femtosecond laser,protoplast cell,continues-wave laser,red cabbage
更新于2025-09-16 10:30:52
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Instantaneous one-dimensional ammonia measurements with femtosecond two-photon laser-induced fluorescence (fs-TPLIF)
摘要： Ammonia (NH3) has been identified as a potential hydrogen-carrier fuel with no carbon emissions. Non-intrusive in-situ NH3 diagnostic technique is of great interest. In this work, femtosecond two-photon laser-induced fluorescence (fs-TPLIF) was demonstrated in NH3/N2 mixtures to achieve NH3 measurements. A femtosecond laser at 305 nm was used for two-photon excitation of NH3 to its excited state (XeC0), and the subsequent fluorescence at ~565 nm from transition C0-A was detected. In addition, a detection limit of 730 ppm was achieved in NH3/N2 mixtures. Furthermore, one-dimensional single-shot images of NH3 were obtained in both laminar and turbulent flow fields. This work is the first attempt of fs-TPLIF for polyatomic molecular gases measurements, and the obtained results indicate that fs-TPLIF could be a promising tool for NH3 measurements.
关键词： Laser-induced fluorescence,Femtosecond laser,Spectroscopy,Ammonia
更新于2025-09-16 10:30:52
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Laser-Ablative Synthesis of Isotope-Enriched Samarium Oxide Nanoparticles for Nuclear Nanomedicine
摘要： Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of 152Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become 153Sm beta-emitters for nuclear therapy. We show that direct ablation of a 152Sm-enriched samarium oxide target leads to widely size- and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.
关键词： nuclear nanomedicine,samarium (Sm) oxide nanoparticles,pulsed laser ablation in liquids,femtosecond laser ablation and fragmentation
更新于2025-09-16 10:30:52
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Influence of target temperature on femtosecond laser-ablated brass plasma spectroscopy
摘要： femtosecond LIBS, a high-temperature and low-density plasma with high emission can be generated by increasing the target temperature. The results showed that, compared with the experimental condition of 25 oC, the spectral intensity of the femtosecond LIP was enhanced with more temperature target. In addition, the electron temperature and density were calculated by Boltzmann equation and Stark broadening, indicating that the changes in the electron temperature and density of femtosecond LIP with the increase of the target temperature were different from each other. By increasing the target temperature, the electron temperature increased while the electron density decreased. Therefore, in femtosecond LIBS, a high-temperature and low-density plasma with high emission can be generated by increasing the target temperature. The increase in the target temperature can improve the resolution and sensitivity of femtosecond LIBS.
关键词： LIBS,femtosecond laser,emission enhancement,laser-induced breakdown spectroscopy,target temperature,time-resolved spectroscopy
更新于2025-09-16 10:30:52
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[Laser Institute of America ICALEO? 2017: 36th International Congress on Applications of Lasers & Electro-Optics - Atlanta, Georgia, USA (October 22–26, 2017)] International Congress on Applications of Lasers & Electro-Optics - Study on laser multi-focus separation technology for thick KDP crystal
摘要： Potassium dihydrogen phosphate (KDP) crystal is an important electro-optic material in various laser system, and belongs to very difficult-to-cut material, especially for thick crystals. In this study, a laser multi-focus separation technology (LMFS) of thick KDP crystal has been developed by skillfully combining femtosecond laser and LMFS optical system. In this way, the uniformity of temperature and thermal stress distributions along crystal thickness and the utilization efficiency of the laser energy are greatly improved. A penetration crack along crystal thickness could be formed and its propagation direction could be controlled to achieve safe and high-quality separation. The separating thickness of LMFS (50 mm) is at least 4 times thicker than that of existing laser separating technology, and the separating efficiency of LMFS (200 mm/s) is at least 20 times faster than that of traditional mechanical method. The generation mechanism of multi-focus was expounded by optical analysis and design, and verified by an established LMFS optical system. A thick KDP crystal with the thickness of 50 mm was separated successfully by LMFS. The quality of the separated sidewall surface was clean and flat (roughness of 10.857 nm, flatness of 3.5389 mm) without any contamination, underground damage and edge fragmentation. The experimental results proved the feasibility of LMFS, and are in good agreement with the theoretical analysis.
关键词： femtosecond laser,KDP crystal,optical system,laser multi-focus separation technology,thermal stress
更新于2025-09-16 10:30:52
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The Study on Tuning Photoluminescence of Colloidal Graphene Quantum Dots Synthesized through Laser Ablation
摘要： We report photoluminescence study of Colloidal Graphene Quantum Dots (GQDs) that synthesized from ablation of rGO solution. The rGO solution was ablated using 800 nm Ti-Sapphire femtosecond laser by varying the synthesize parameters such as laser power and ablation time. We observed that changing laser power 1 Watt to become 1.7 Watt and time ablation 20 minutes to become 60 minutes will alterate the Photoluminescence (PL) curve peak of GQDs. In case of ablation power variation, PL data shows that the PL curve peak excited by 280 nm laser changed from 369.09 nm to 371.02 nm, and when it excited by 290 nm the PL curve peak slightly changed from 388.17 nm to 393.8 nm. The alteration of Photoluminescence peak is also observed in the variation of time ablation experiment, The PL curve peaks from GQDs time ablation variation samples excited by 280 nm were slightly changed from 376.81 nm to 373.59 nm, and when it excited by 290 nm laser, the PL curve peak is 391.55 nm then changed to 392.11. The change of PL peak on laser power or time ablation variation shows that both parameters will alter either the size, shape, or the edge-type of GQDs.
关键词： Laser Ablation,Ti-Sapphire Femtosecond Laser,Graphene Quantum Dots,Photoluminescence,Reduced Graphene Oxide
更新于2025-09-16 10:30:52