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Construction of n-TiO2/p-Ag2O Junction on Carbon Fiber Cloth with Visa??NIR Photoresponse as a Filter-Membrane-Shaped Photocatalyst
摘要： The development of effective and reusable photocatalysts with broad-spectra activity has attracted attention. Herein, we have constructed n-TiO2/p-Ag2O junction on carbon fiber (CF) cloth as an efficient and recyclable photocatalyst. With CF cloth as the substrate, TiO2 nanorods (length: 1–2 μm) are prepared by a hydrothermal process, and the in-situ growth of Ag2O nanoparticles (10–20 nm) is then realized by chemical bath deposition route. The flexible CF/TiO2/Ag2O cloth (area: 4 × 4 cm2) shows a broad and strong photo-absorption (200–1000 nm). Under the illumination of visible-light (λ > 400 nm), CF/TiO2/Ag2O cloth can efficiently eliminate 99.2% rhodamine B (RhB), 99.4% acid orange 7 (AO7), 87.6% bisphenol A (BPA), and 89.5% hexavalent chromium (Cr6+) in 100 min, superior to CF/Ag2O cloth (83.5% RhB, 60.0% AO7, 31.2% BPA and 41.8% Cr6+). In particular, under the NIR-light illumination (980 nm laser), CF/TiO2/Ag2O cloth can remove 70.9% AO7 and 60.0% Cr6+ in 100 min, which are significantly higher than those by CF/Ag2O cloth (19.8% AO7 and 18.9% Cr6+). In addition, CF/TiO2/Ag2O cloth (diameter: 10 cm), as a filter-membrane, can effectively wipe off 94.4% flowing RhB solution (rate: ~ 1 L h? 1) at 6th filtering/degrading grade. Thus, CF/TiO2/Ag2O cloth can be used as a Vis–NIR-responded filter-membrane-shaped photocatalyst with high-efficiency for purifying wastewater.
关键词： n-TiO2/p-Ag2O junction,Filter-membrane,Photocatalyst,Vis-NIR photoresponse,Carbon fiber cloth
更新于2025-09-23 15:21:01
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Determination of parvovirus retention profiles in virus filter membranes using laser scanning microscopy
摘要： Virus filtration is a highly effective method in the downstream processing of biotherapeutic products to provide effective removal of potential infectious agents based on a size exclusion mechanism. The direct visualization of viruses retained inside the filter membrane represents a valuable tool to get a deeper understanding of the filtration process and to explain observations of virus breakthrough under particular operating conditions. Parvoviruses, which are used as worst-case models in validation studies, were purified and labeled with fluorescent dyes to detect their retention pattern inside the filter membrane using laser scanning microscopy. Critical factors influencing the reproducibility and accuracy of the approach were identified and optimized. The retention profiles revealed detectable differences between viruses, suggesting that the use of bacteriophages or nanoparticles as surrogates is limited in their applicability to accurately predict the behavior of parvoviruses in filter membranes. The established method enables a direct and quantitative analysis of the virus retention profile, adding a valuable tool to the conventional measurement of the viral load reduction to better understand the mechanism underlying the removal of viruses during nanofiltration of biotherapeutic products.
关键词： Parvovirus retention profile,Virus filtration,Nanofiltration,Laser scanning microscopy,Filter membrane
更新于2025-09-23 15:19:57
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<p>Filter-Membrane-Based Ultrafiltration Coupled with Surface-Enhanced Raman Spectroscopy for Potential Differentiation of Benign and Malignant Thyroid Tumors from Blood Plasma</p>
摘要： The objective of this study is to evaluate the performance and feasibility of surface-enhanced Raman spectroscopy coupled with a filter membrane and advanced multivariate data analysis on identifying and differentiating benign and malignant thyroid tumors from blood plasma. We proposed a membrane filter SERS technology for the differentiation between benign thyroid tumor and thyroid cancer. That is to say, by using filter membranes with optimal pore size, the blood plasma samples from thyroid tumor patients were pretreated with the macromolecular proteins being filtered out prior to SERS measurement. The SERS spectra of blood plasma ultrafiltrate obtained using filter membranes from 102 patients with thyroid tumors (70 thyroid cancers and 32 benign thyroid tumors) were then analyzed and compared. Two multivariate statistical analyses, principal component analysis-linear discriminate and Lasso-partial least squares-discriminant analysis (Lasso-PLS-DA), were performed on the SERS spectral data after background subtraction and normalization, as well as the first derivative processing, to analyze and compare the differential diagnosis of benign thyroid tumors and thyroid cancer. SERS measurements were performed in blood plasma acquired from a total of 102 thyroid tumor patients (benign thyroid tumor N=32; thyroid cancer N=70). By using filter membranes, the macromolecular proteins in blood plasma were effectively filtered out to yield high-quality SERS spectra. 84.3% discrimination accuracy between benign and malignant thyroid tumor was achieved using PCA-LDA method, while Lasso-PLS-DA yields a discrimination accuracy of 90.2%. Our results demonstrate that SERS spectroscopy, coupled with ultrafiltration and multivariate analysis has the potential of providing a non-invasive, rapid, and objective detection and differentiation of benign and malignant thyroid tumors.
关键词： thyroid tumor,silver nanoparticles,filter membrane,blood plasma,surface-enhanced Raman spectroscopy
更新于2025-09-19 17:13:59
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MoS2/Bi2S3 heterojunctions-decorated carbon-fiber cloth as flexible and filter-membrane-shaped photocatalyst for the efficient degradation of flowing wastewater
摘要： Traditional powder/film-shaped photocatalysts suffer some serious limitations (such as recycling difficulty or high-cost) in the degradation of flowing wastewater. Herein, we report a novel filter-membrane-shaped photocatalyst by constructing MoS2/Bi2S3 heterojunctions on carbon-fiber cloth (CF/MoS2/Bi2S3 cloth). CF/MoS2/Bi2S3 cloth consists of carbon-fibers (diameter: ~ 15 μm) which are decorated with numerous MoS2 nanosheets (thickness: ~ 2 nm) and Bi2S3 nanorods (length: 500 ~ 600 nm), and it exhibits a broad-spectrum photoabsorption from ultraviolet to near-infrared region (> 1200 nm). Under visible-light irradiation, CF/MoS2/Bi2S3 cloth (area: 4 × 4 cm2) exhibits the highest photocurrent (~ 1.44 mA cm-2) and can photocatalytically remove 95.1% rhodamine B (RhB), 91.8% methylene blue (MB), 74.5% tetracycline (TC) and 75.5% hexavalent chromium (Cr(VI)) after 100 min, better than those by CF/MoS2 cloth (37.0% RhB, 39.9% MB, 29.6% TC, 21.6% Cr(VI)) and CF/Bi2S3 cloth (26.9% RhB, 27.4% MB, 20.9% TC, 25.9% Cr(VI)). Importantly, when flexible CF/MoS2/Bi2S3 cloth (diameter: 10 cm) is used as the filter-membrane to degrade the flowing wastewater (rate: ~ 1 L h-1), the removal efficiency of RhB increases from 19.7% at 1st to 94.6% at 8th filtering/degrading grade. Thus, CF/MoS2/Bi2S3 cloth has excellent potential as a novel filter-membrane-shaped photocatalyst to degrade the flowing wastewater.
关键词： MoS2/Bi2S3,carbon-fiber cloth,flowing wastewater,filter-membrane,photocatalysis
更新于2025-09-11 14:15:04
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Paper-based Versatile SERS Chip with Smartphone-based Raman Analyzer for Point of Care Application
摘要： With the advanced development of the miniaturized Raman spectroscopy, surface enhanced Raman spectroscopy (SERS) has extended its applications into the field of Point of Care Testing (POCT) and demonstrated its great significance in virtue non-invasive property and capability of fingerprint identification. In the SERS-based analysis and/or sensing system, the preparation of low cost, high-performance SERS substrate is critically important. In this manuscript, vacuum filtration is utilized to fabricate the silver nanoparticles (AgNPs) embedded nylon filter membrane (ANFM) as flexible paper-based SERS chips. By characterizing the typical analytes with the miniaturized smartphone-based Raman analyzer, the proposed SERS chips have successfully demonstrated good sensitivity, repeatability and stability. The lowest concentration as detected can approach 1 pmol for Rhodamine 6G (RH6G) and 10 pmol for both crystal violet (CV) and malachite green (MG), respectively. With the help of microporous structure of the membrane, the ANFM based SERS chips can implement the separation of small molecules from complex mixture and can achieve “purified” SERS signals of targeted molecules. Besides, with the function of anti-friction resistance and flexibility, the ANFM can serve as SERS papers to pre-concentrate the contaminates by multiple swapping and further enhance the SERS signals for point of care analysis. Therefore, we demonstrate multi-functions of the flexible ANFM based SERS chips, which provides a promising solution for the POCT analysis with SERS technique on account of its flexibility and low fabrication cost.
关键词： silver nanoparticles,SERS chips,nylon filter membrane,Point of Care Testing,smartphone-based Raman analyzer,Surface-enhanced Raman spectroscopy
更新于2025-09-09 09:28:46