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Facile fabrication of cross-linked fluorescent organic nanoparticles with aggregation-induced emission characteristic via the thiol-ene click reaction and their potential for biological imaging
摘要： Over the past several years, the biomedical applications of fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature have been extensively explored because the AIE-active FONs could effectively overcome the aggregation caused quenching (ACQ) effect of FONs based on conventional organic dyes. The development of novel methods for synthesis of AIE-active FONs plays a centre role for their biomedical applications. In this work, we reported a facile one-step thiol-ene click reaction for fabrication of AIE-active FONs through conjugation of acrylated PEG and AIE-active tetraphenylethylene (TPE) with two ene bonds using pentaerythritol tetra(3-mercaptopropionate) as the linkage. The successful synthesis of TPE containing AIE-active copolymers was evidenced by various characterization techniques. The particle size and fluorescence properties of the resultant TPE-S-PEG copolymers were evaluated by transmission electronic microscopy and fluorescence spectroscopy. Moreover, the cell viability and cell uptake behavior was also examined to evaluate their potential for biological imaging. We demonstrated that the cross-linked TPE-S-PEG show small size, high water dispersibility, low cytotoxicity and strong fluorescence for tracing. All of these advantages endow the TPE-S-PEG FONs great potential for biological imaging applications. Furthermore, this novel click reaction can take place under mild experimental conditions with high efficiency. It could be also further expanded for preparation of multifunctional AIE-active materials due to the universality of the thiol-ene click reaction and good precursor applicapability. Taken together, we have developed a novel and effective thiol-ene click reaction to fabricate the cross-linked AIE-active FONs, which display excellent physicochemical and biological properties and are promising for biomedical applications.
关键词： thiol-ene click reaction,Aggregation-induced emission,biomedical applications,fluorescent organic nanoparticles,cross-linked FONs
更新于2025-09-23 15:23:52
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High Performance Fluorescent Turn-On Probe for Amitriptyline Based on Hybrid Nanoassembly of Organic–Inorganic Nanoparticles
摘要： Fluorescence methods have gained enormous attention due to their ease in use, simplicity, selectivity and sensitivity. Fluorescent chemosensors respond instantly by converting molecular recognition to fluorescent signals. The consumption of pharmaceutical products by living beings is on great increase. The disposal of such compounds in the environment is a matter of great concern as these compounds enter aquatic environment and are showing accumulation in tissues of aquatic organisms. In the present study, we have utilized naphthalimide based receptors to fabricate organic nanoparticles. These ONPs were used for the development of hybrid nanoassemblies and the developed nanoassemblies were characterized with the help of TEM and DLS studies. The photophysical studies were performed and the hybrid assembly developed using receptor 2 demonstrated a turn-on fluorescence emission behaviour on binding with Amitriptyline. The present sensing system acted as promising candidate for determination of Amitriptyline among other contending drug molecules. The established system can recognize amitriptyline up to a detection limit of 48 nM in aqueous medium. Electrochemical recognition studies show binding of hybrid nanoassembly of receptor 2 with Amitriptyline with limit of detection of 21 nM.
关键词： Turn-On Probe,Fluorescent Organic Nanoparticles,Amitriptyline,Nanomolar Detection,Hybrid Nanoassembly
更新于2025-09-23 15:21:21
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Fluorescent Chemosensor for Quantitation of Multiple Atmospheric Gases
摘要： Recently, the sensing and monitoring of gases from ambient as well as industrial sources has gained a great importance in order to ensure occupational hygiene, public health, and societal welfare. The development of new technologies for visualizing and detecting gases at trace levels is imperative for various applications. There exist several established traditional methods to detect different gases. In this article, we review the latest trends in the area of fluorescence sensing of gas molecules, which is a high sensitivity technique with minimum or negligible interferences. The gas sensors fabricated with the use of fluorescent nanoparticles as detecting elements possess special feature, like high surface-to-volume ratios, ultra sensitivity, enhanced selectivity, cost effectiveness, and fast response. The inherent properties of the related systems, e.g. a large fluorescence lifetime, nanoscale particle size and a tunable zeta potential, make it possible to devise fluorescent sensors with an attractive pathway of fluorescence ‘off–on’. Several fluorimetric methods are known to detect specific gases from the atmospheric gaseous samples with satisfactory detection results. Modern fluorescent gas sensors are did not cause interference from the co-pollutants thus making the fluorimetric sensing process to be quantitative as well as specific.
关键词： Atmospheric environmental sample,Fluorescent gas sensor,Job’s plot,Fluorescent organic nanoparticles,Analytical method,Fluorescence lifetime
更新于2025-09-04 15:30:14