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Controllable preparation of phase-separated Pb/Zn heterogeneous nanoparticles by laser ablation and their application in the growth of PbS tipped ZnS nanorods heterostructures
摘要： Phase-separated Pb/Zn heterogeneous nanoparticles (Pb/Zn HNPs) with a controllable phase ratio were firstly prepared by long-pulse-width millisecond laser ablation of Pb/Zn binary metal target immersed in anhydrous ethanol under room conditions. The phase ratio in the as-ablated Pb/Zn HNPs was mainly determined by the molar ratio of Pb/Zn in the initial binary metal target and the structure of Pb/Zn HNPs was partly influenced by the pulse laser width. Then the PBS tipped ZnS nanorods heterostructures (PbS/ZnS heterostructures) were grown by simply heating the mixture of the as-ablated Pb/Zn HNPs and thioacetamide (TAA) at 450 (cid:1)C in a tube furnace. The size and morphology of Pbs/ZnS heterostructures were decided by the original absolute size and relative size between phase-separated Pb and Zn nanoparticle. The formation of Pbs/ZnS heterostructures was the result of the diffusion-limited of S atoms in the Pb/Zn HNPs. This study not only provides a new strategy for the controllable preparation of phase-separated bimetallic nanoparticles that can be used for the growth of specific heterostructures but a new view on the fundamental physical and chemical aspects of nanocrystal formation after laser ablation of solids in liquids.
关键词： Heterostructure,Phase-separated,Heterogeneous nanoparticles,Laser ablation,Binary metal target,Diffusion-limited
更新于2025-11-14 17:04:02
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Boosting the Radiosensitizing and Photothermal Performance of Cu <sub/>2-x</sub> Se Nanocrystals for Synergetic Radiophotothermal Therapy of Orthotopic Breast Cancer
摘要： The small difference between tumor and normal tissues in their responses to ionizing radiation has been a significant issue for radiotherapy of tumors. Herein, we report that dumbbell-shaped heterogeneous copper selenide-gold nanocrystals can serve as an efficient radiosensitizer for enhanced radiotherapy. The mean lethal dose of X-rays to 4T1 tumor cells can be drastically decreased about 40%, i.e., decreasing from 1.81 Gy to 1.10 Gy after culture with heterostructures. Due to the synergetic effect of heterostructures, the dose of X-rays is also much lower than those obtained from mixture of Cu2-xSe + Au nanoparticles (1.78 Gy), Cu2-xSe nanoparticles (1.72 Gy) and Au nanoparticles (1.50 Gy), respectively. We demonstrate that the sensitivity enhancement ratio of Cu2-xSe nanoparticles was significantly improved 45% (i.e., from 1.1 to 1.6) after the formation of heterostructures with gold. We also show that the hetero-nanocrystals exhibit an enhanced photothermal conversion efficiency, due to the synergetic interactions of localized surface plasmon resonance. These properties highly feature them as a multimodal imaging contrast agent (particular for photoacoustic imaging, computed tomography imaging, and single photon emission computed tomography after labeled with radioisotopes) and as a radiosensitizer for imaging guided synergetic radiophotothermal treatment of cancer. The research provides insights for engineering low-Z nanomaterials with high Z elements to form hetero-nanostructures with enhanced synergetic performance for tumor theranostics.
关键词： radiosensitizer,multimodal imaging,radiotherapy,heterogeneous nanoparticles,photothermal therapy
更新于2025-09-19 17:15:36