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Influence of the supramolecular arrangement of iron phthalocyanine thin films on catecholamine oxidation
摘要： The versatility of iron phthalocyanine (FePc) to form distinct supramolecular arrangements in thin films, characterized by their thickness, molecular organization, morphology, and crystallinity, can be used to tune the electrochemical oxidation of catecholamines, becoming a promising material for sensing applications. Here, Langmuir-Schaefer (LS) and electrodeposition (ED) techniques have been used to produce thin films of FePc with different supramolecular arrangements on ITO electrodes. Both types of modified electrode were evaluated for the electrochemical oxidation of L-Dopa, dopamine (DA), norepinephrine (NEp), and epinephrine (Ep) in aqueous solution. The effect of scan rate, potential range, presence of oxygen, and pH were also evaluated, having an influence on the electrochemical oxidation of catecholamines. The FePc/ED modified electrodes showed two distinct peaks in the presence of mixtures of DA/L-Dopa and DA/Ep, while for FePc/LS modified electrodes an overlap of the oxidation waves was observed. This behaviour reveals the influence of the supramolecular arrangement of FePc on catecholamine oxidation. The FePc/LS modified electrodes showed a limit of detection of 0.024 μmol L-1 for DA and 0.168 μmol L-1 for L-Dopa, while FePc/ED showed limits of detection of 0.288 μmol L-1 and 0.564 μmol L-1, respectively. The FePc films showed suitable properties for future application as catecholamine sensors.
关键词： electrodeposition,Langmuir-Schaefer,iron phthalocyanine,catecholamines
更新于2025-09-23 15:23:52
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Construction of the 0D/2D heterojunction of Ti3C2Tx MXene nanosheets and iron phthalocyanine quantum dots for the impedimetric aptasensing of microRNA-155
摘要： A promising nanocarrier of the complementary DNA (cDNA) toward miRNA-155 was synthesized on the basis of the nanohybrid type of Ti3C2Tx MXene nanosheets decorated using iron phthalocyanine quantum dots (FePc QDs) (denoted as Ti3C2Tx@FePcQDs) to construct a novel ultrasensitive impedimetric aptasensing system for microRNA-155 (miRNA-155). Owing to π–π* stacking interaction between Ti3C2Tx nanosheets and FePc QDs, the homogeneous nanostructure of the Ti3C2Tx@FePcQD nanohybrid that comprises mixed-valence states (Ti2+/Ti3+ and Fe2+/Fe3+), multicomponent (Ti-O and Ti-C), and various N-related groups was achieved. The constructed Ti3C2Tx@FePcQDs-based aptasensor displayed an ultrahigh sensitivity for detecting miRNA-155 with a low detection limit of 4.3 aM (S/N = 3) within the miRNA-155 concentration ranging from 0.01 fM to 10 pM. Compared with the individual component-based aptasensors and other reported miRNA-155 aptasensors, the proposed impedimetric aptasensing system exhibited substantial merits of a feasible preparation process, non-use of labels or electrochemical indicators, fast response time, and comprehensive sensing performances for detecting miRNA-155. This strategy for determining miRNAs can extensively be applied as the platform for anchoring other kinds of aptamers in detecting diverse targets, thus indicating its great potential application for the early diagnosis of cancer biomarkers.
关键词： Impedimetric aptasensing,Iron phthalocyanine,Nanohybrid,Detection of miRNA-155,Ti3C2Tx MXene nanosheets,Electrochemical aptasensor
更新于2025-09-23 15:19:57