Peripheral Defocus of the Monkey Crystalline Lens With Accommodation in a Lens Stretcher

摘要： PURPOSE. To characterize the peripheral defocus of the monkey crystalline lens and its changes with accommodation. METHODS. Experiments were performed on 15 lenses from 11 cynomolgus monkey eyes (age: 3.8–12.4 years, postmortem time: 33.5 6 15.3 hours). The tissue was mounted in a motorized lens stretcher to allow for measurements of the lens in the accommodated (unstretched) and unaccommodated (stretched) states. A custom-built combined laser ray tracing and optical coherence tomography system was used to measure the paraxial on-axis and off-axis lens power for delivery angles ranging from (cid:2)208 to t208 (in air). For each delivery angle, peripheral defocus was quanti?ed as the difference between paraxial off-axis and on-axis power. The peripheral defocus of the lens was compared in the unstretched and stretched states. RESULTS. On average, the paraxial on-axis lens power was 52.0 6 3.4 D in the unstretched state and 32.5 6 5.1 D in the stretched state. In both states, the lens power increased with increasing delivery angle. From 08 to t208, the relative peripheral lens power increased by 10.7 6 1.4 D in the unstretched state and 7.5 6 1.6 D in the stretched state. The change in ?eld curvature with accommodation was statistically signi?cant (P < 0.001), indicating that the unstretched (accommodated) lens has greater curvature or relative peripheral power. CONCLUSIONS. The cynomolgus monkey lens has signi?cant accommodation-dependent curvature of ?eld, which suggests that the lens asserts a signi?cant contribution to the peripheral optical performance of the eye that also varies with the state of accommodation.