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An algorithmic approach to single probe Cherenkov removal in pulsed X-ray beams
摘要： Purpose: The removal of Cherenkov light in an optical dosimetry system is an important process to ensure accurate dosimetry without compromising spatial resolution. Many solutions have been presented in the literature, each with advantages and disadvantages. We present a methodology to remove Cherenkov light from a scintillator fibre optic dosimeter in a pulsed megavoltage X-ray beam using the temporal waveform across the pulse. Methods: A sample waveform of Cherenkov light can be measured by exposing only the fibre to the beam. By assuming that the Cherenkov waveform closely matches the intensity of incident radiation, this waveform can be convoluted with the instantaneous scintillation response function to generate an expected scintillation signal. By finding the least-squares fit between these two functions and the experimental data, the estimated Cherenkov contribution can be subtracted off the net signal. This can be applied for arbitrarily complex Cherenkov waveforms (within the 2 ns timing resolution of the data acquisition), and in fact the results suggest more fluctuations in the waveforms provide a better fit to data. Results: Four beam profiles for different field sizes and energies were found with this method. They closely matched references data measured with ionisation chamber with average differences across the beam no more than 4%. Noisy waveforms are assumed to be the primary cause of differences between the analysed scintillator and IC results. We propose methods for improving the results and optimising the data acquisition and analysis processes. Conclusions: These results demonstrate that it is possible and effective with a single probe to use function-fitting of expected data to experimental to remove a complicated Cherenkov signal from the net light signal in pulsed-beam optical dosimetry.
关键词： x-ray,scintillators,fiber-optic dosimetry,microbeam radiation therapy
更新于2025-09-23 15:23:52
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Conformal image-guided microbeam radiation therapy at the ESRF biomedical beamline ID17
摘要： Purpose: Upcoming veterinary trials in microbeam radiation therapy (MRT) demand for more advanced irradiation techniques than in preclinical research with small animals. The treatment of deep-seated tumors in cats and dogs with MRT requires sophisticated irradiation geometries from multiple ports, which impose further efforts to spare the normal tissue surrounding the target. Methods: This work presents the development and benchmarking of a precise patient alignment protocol for MRT at the biomedical beamline ID17 of the European Synchrotron Radiation Facility (ESRF). The positioning of the patient prior to irradiation is verified by taking x-ray projection images from different angles. Results: Using four external fiducial markers of 1.7 mm diameter and computed tomography-based treatment planning, a target alignment error of less than 2 mm can be achieved with an angular deviation of less than 2?. Minor improvements on the protocol and the use of smaller markers indicate that even a precision better than 1 mm is technically feasible. Detailed investigations concerning the imaging dose lead to the conclusion that doses for skull radiographs lie in the same range as dose reference levels for human head radiographs. A currently used online dose monitor for MRT has been proven to give reliable results for the imaging beam. Conclusions: The ESRF biomedical beamline ID17 is technically ready to apply conformal image-guided MRT from multiple ports to large animals during future veterinary trials.
关键词： microbeam radiation therapy,image-guidance,x-ray imaging,fiducial markers,synchrotron radiation
更新于2025-09-23 15:22:29