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- 2015
- Xanthomonas oryzae
- multispectral and multimodal microscopy
- spectroscopic imaging
- plant cell diseases
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- rice
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- University of Sciences, Technique and Technology Bamako
- Institut National Polytechnique Felix Houphou?t-Boigny Yamoussoukro
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[IEEE 2018 XIV International Scientific-Technical Conference on Actual Problems of Electronics Instrument Engineering (APEIE) - Novosibirsk, Russia (2018.10.2-2018.10.6)] 2018 XIV International Scientific-Technical Conference on Actual Problems of Electronics Instrument Engineering (APEIE) - Up-to-Date Thermal Imaging Systems in the Multichannel Automated Measurements
摘要： A highly informative methodology, the essence of which is to obtain the parameters of an object under study by means of the data synchronous acquisition from several measurement channels, predominantly based on different physical principles, infrared thermography (IRT) as a leading research tool included in such a multichannel (multimodal) measuring system is considered in some detail. The IRT-aided multichannel approach is demonstrated with studying the physiological characteristics in humans. The measurement synchronism of different technical means is realized by the computerization and automation of the experiment. The programmable microcontroller ESP32 served as main operating and readout unit. With a time resolution of 100-200 measurements per second, the experimental data were obtained. It made it possible to reveal the human physiological characteristics as follows: the extremities temperature change, pulse waves and their velocity in the radial artery, breathing dynamics, blood pressure evaluated in two different regimes of brachial cuff air filling – inflation and deflation. The brachial cuff inflation also served as external interventional impact on the organism. It is found that, after the brachial artery cross-clamping, the pulse wave velocity in the radial artery is capable of doubling in comparison with that measured before compression. It is shown that the multimodal technology is a promising means in modern experimental science.
关键词： SEIRT,blood pressure measurement,breathing dynamics,experiment automation,multichannel (multimodal) measurements,pulse wave velocity,Infrared thermography,thermal imaging,programmable microcontroller,pulse wave,computer-aided measurements
更新于2025-09-04 15:30:14
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Multimodal cantilevers with novel piezoelectric layer topology for sensitivity enhancement
摘要： Self-sensing techniques for atomic force microscope (AFM) cantilevers have several advantageous characteristics compared to the optical beam deflection method. The possibility of down scaling, parallelization of cantilever arrays and the absence of optical interference associated imaging artifacts have led to an increased research interest in these methods. However, for multifrequency AFM, the optimization of the transducer layout on the cantilever for higher order modes has not been addressed. To fully utilize an integrated piezoelectric transducer, this work alters the layout of the piezoelectric layer to maximize both the deflection of the cantilever and measured piezoelectric charge response for a given mode with respect to the spatial distribution of the strain. On a prototype cantilever design, significant increases in actuator and sensor sensitivities were achieved for the first four modes without any substantial increase in sensor noise. The transduction mechanism is specifically targeted at multifrequency AFM and has the potential to provide higher resolution imaging on higher order modes.
关键词： multimodal AFM,atomic force microscopy,multifrequency AFM,self-sensing,piezoelectric cantilever
更新于2025-09-04 15:30:14
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Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy
摘要： Catalytic deoxyribozyme has great potential for gene regulation, but poor efficiency of the cleavage of mRNA and lack of versatile DNAzyme vehicles remain big challenges for potent gene therapy. By rational designing a diverse vehicle of polydopamine-Mn2+ nanoparticles (MnPDA), we demonstrate that MnPDA has integrated functions as an effective DNAzyme delivery vector, self-generation source of DNAzyme cofactor for catalytic mRNA cleavage, inherent therapeutic photothermal agent, as well as contrast agents for photoacoustic and magnetic resonance imaging. Specifically, the DNAzyme-MnPDA nanosystem protects catalytic deoxyribozyme from degradation and enhances cellular uptake efficiency. In the presence of intracellular glutathione, the nanoparticles are able to in-situ generate free Mn2+ as a cofactor of DNAzyme to effectively trigger catalytic cleavage of mRNA for gene silencing. In addition, the nanosystem shows high photothermal conversion efficiency and excellent stability against photothermal processing and degradation in complex environments. Unlike previous DNAzyme delivery vehicles, this vehicle exhibits diverse functionalities for potent gene regulation, allowing multimodal imaging-guided synergetic gene regulation and photothermal therapy both in vitro and in vivo.
关键词： deoxyribozyme,multimodal imaging,photothermal therapy,DNAzyme,gene therapy
更新于2025-09-04 15:30:14
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Progression of retinitis pigmentosa on multimodal imaging: the PREP‐1 study
摘要： Importance: It is important to establish reliable outcome measures to detect progression in retinitis pigmentosa (RP). Background: To evaluate progression of RP using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimetry (MP). Design: Retrospective longitudinal study at a tertiary teaching hospital. Participants: 205 eyes of 106 patients with RP with 1-5 years of follow-up. Methods: Demographics and visual acuity (VA) were recorded, and each modality was graded at baseline and every annual follow-up. SD-OCT was graded for the width of ellipsoid zone (EZ), FAF was graded for the diameter and area of the hyperautofluorescent ring (if present), and MP was graded for mean, central and paracentral sensitivity. Spearman’s correlation was used to measure correlations at baseline. Mixed effects models were used to estimate the annual change of each parameter, adjusted for disease duration. Main outcome measures: Rate of progression. Results: The median VA at baseline was 75 letters and was positively correlated with mean and central sensitivity (r: 0.372 and 0.394; p=0.01 for both). All parameters (except paracentral sensitivity) were strongly correlated with each other (r: 0.673-0.991; p<0.001 for all). The annual rates of change for each parameter were as follows: VA, -2.3 letters (p<0.001); EZ, -151um (p<0.001); ring diameter, -132um (p<0.001); ring area, -0.4mm2 (p<0.001); mean sensitivity, -0.3 dB (p<0.001); central sensitivity, -0.7 dB (p<0.001); paracentral sensitivity, -0.4 dB (p<0.001). Conclusion and relevance: Structural and functional measures are well correlated in RP and can reliable measure disease progression within the course of a year.
关键词： Optical Coherence Tomography,Multimodal Imaging,Microperimetry,Fundus Autofluorescence,Disease Progression
更新于2025-09-04 15:30:14
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A machine learning approach for online automated optimization of super-resolution optical microscopy
摘要： Traditional approaches for finding well-performing parameterizations of complex imaging systems, such as super-resolution microscopes rely on an extensive exploration phase over the illumination and acquisition settings, prior to the imaging task. This strategy suffers from several issues: it requires a large amount of parameter configurations to be evaluated, it leads to discrepancies between well-performing parameters in the exploration phase and imaging task, and it results in a waste of time and resources given that optimization and final imaging tasks are conducted separately. Here we show that a fully automated, machine learning-based system can conduct imaging parameter optimization toward a trade-off between several objectives, simultaneously to the imaging task. Its potential is highlighted on various imaging tasks, such as live-cell and multicolor imaging and multimodal optimization. This online optimization routine can be integrated to various imaging systems to increase accessibility, optimize performance and improve overall imaging quality.
关键词： machine learning,multicolor imaging,online automated optimization,live-cell imaging,super-resolution optical microscopy,multimodal optimization
更新于2025-09-04 15:30:14
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Radiation-responsive scintillating nanotheranostics for reduced hypoxic radioresistance under ROS/NO-mediated tumor microenvironment regulation
摘要： Abstract: Hypoxia-induced radioresistance is the primary reason for failure of tumor radiotherapy (RT). Changes within the irradiated tumor microenvironment (TME) including oxygen, reactive oxygen species (ROS) and nitric oxide (NO) are closely related to radioresistance. Therefore, there is an urgent need to develop new approaches for overcoming hypoxic radioresistance by incorporating TME regulation into current radiotherapeutic strategies. Methods: Herein, we explored a radiation-responsive nanotheranostic system to enhance RT effects on hypoxic tumors by multi-way therapeutic effects. This system was developed by loading S-nitrosothiol groups (SNO, a NO donor) and indocyanine green (ICG, a photosensitizer) onto mesoporous silica shells of Eu3+-doped NaGdF4 scintillating nanocrystals (NSC). Results: Under X-ray radiation, this system can increase the local dosage by high-Z elements, promote ROS generation by X-ray-induced photodynamic therapy, and produce high levels of NO to enhance tumor-killing effects and improve hypoxia via NO-induced vasodilation. In vitro and in vivo studies revealed that this combined strategy can greatly reinforce DNA damage and apoptosis of hypoxic tumor cells, while significantly suppressing tumor growth, improving tumor hypoxia and promoting p53 up-regulation and HIF1α down-regulation. In addition, this system showed pronounced tumor contrast performance in T1-weighted magnetic resonance imaging and computed tomography. Conclusion: This work demonstrates the great potential of scintillating nanotheranostics for multimodal imaging-guided X-ray radiation-triggered tumor combined therapy to overcome radioresistance.
关键词： X-ray induced photodynamic therapy,hypoxia-induced radioresistance,nanoscintillators,multimodal imaging,nitric oxide
更新于2025-09-04 15:30:14
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[Communications in Computer and Information Science] Advanced Informatics for Computing Research Volume 955 (Second International Conference, ICAICR 2018, Shimla, India, July 14–15, 2018, Revised Selected Papers, Part I) || A Brief Review of Image Quality Enhancement Techniques Based Multi-modal Biometric Fusion Systems
摘要： An extensive amount of system needs reliable schemes for personal recognition to con?rm the individual identity demanding the services. The aim of these schemes is the authentication of services that can be executed from the genuine user only. Tremendous growth has been seen from last few years in biometric recognition because of the increased requirement of consistent personal identi?cation with the varied government and commercial applications. The biometric recognition is termed as automatic individual recognition on the basis of physiological or behavioural characteristics. This paper provides a brief outline of biometric ?eld and sums up the biometric modalities, biometric framework, and biometric system classi?cation with Image Quality Improvement Techniques. Work done by number of authors in the similar ?eld has been analyzed and de?ned. The review has also shown the observation of different modalities for recognition accuracy with FAR and FRR.
关键词： Biometric modalities,Unimodal and multimodal biometric system,Image Quality Improvement Techniques,Biometric recognition
更新于2025-09-04 15:30:14
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[IEEE IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Valencia (2018.7.22-2018.7.27)] IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium - Automatic Coregistration of SAR and Optical Images Exploiting Complementary Geometry and Mutual Information
摘要： Image coregistration aims at stacking two or multiple images in a way such that, for each image, the same pixel corresponds to the same point of the target scene (possibly with sub-pixel accuracy). We can distinguish two families of image coregistration problems, basically depending on if the images to be coregistered are taken by sensors of the same or different type (e.g., sensing different wavelenghts), and with similar or different illumination and acquisition geometries (e.g. different sun illumination conditions and/or different acquisition incidence angles).Whilst the first type of image coregistration is well established, multimodal coregistration is not yet well founded and due to difficulty of finding correspondences between the images (tie points) in a robust way, and the available approaches often recur to manual assistance. The multimodal image coregistration technique proposed in this work overcomes the problems due to differences in radiometries and in geometries by exploiting two main concepts: complementary geometry information between the images to be coregistered, and mutual information (or entropy) as similarity metric. The method focuses on coregistration of very high resolution synthetic aperture radar (SAR) and optical images, but the approach is of general validity. The tests performed on real very high resolution optical and SAR data confirm the validity of the method.
关键词： SAR feature extraction,image coregistration,mutual information,bundle adjustment,multimodal image coregistration
更新于2025-09-04 15:30:14
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Intraoperative OCT imaging of the Argus II retinal prosthesis and its clinical significance
摘要： To report the clinical, multimodal imaging and genetic characteristics of patients with Enhanced-S-cone syndrome (ESCS) in a Tunisian cohort. Methods: Descriptive clinical and genetic study including patients with inherited retinal dystrophies who consulted the oculogenetics laboratory LR14SP01, at Hedi Rais Institute of ophthalmology. Results: A total of 9 patients from 6 consanguineous families were diagnosed with ESCS based on typical clinical and ERG abnormalities. All patients complaint from hemeralopia since childhood. Visual acuity ranged from light perception to 4/10. Fundus examination revealed variable abnormalities with radial yellow dots in the posterior pole in two patients, nummular yellow dots in one patient, minimal pigmentary changes along the arcades in five patients, nummular pigment clumping in 3 patients and peripheral retinal atrophy in one patient. One patient had macular atrophy and 8 had macular cysts confirmed by SS-OCT. Genetic analysis was contributive in 7 patients and revealed NR2E3 mutations in 5 patients and NR2E3 + RHO digenism in two patients from the same family. Conclusions: This is to our knowledge the first report on a Tunisian cohort with ESCS. The phenotype in ESCS is highly variable and multimodal imaging may help to the diagnosis in addition to electrophysiology results.
关键词： genetic characteristics,ESCS,multimodal imaging,Enhanced-S-cone syndrome,Tunisian cohort
更新于2025-09-04 15:30:14
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Acute subretinal abscess in <i>Staphylococcus aureus</i> septicaemia with endophthalmitis showcased by multimodal retinal imaging and with 2-year follow-up
摘要： A middle-aged man presented to emergency services with central vision loss in the setting of flu-like illness with fever. A striking subfoveal abscess was observed in the right fundus. Focal acute chorioretinal inflammation was noted in the asymptomatic fellow eye. Staphylococcus aureus septicaemia was subsequently diagnosed. He presented with undiagnosed HIV infection and latent syphilis. Serial high-definition multimodal retinal imaging showcased resolution of the dome-shaped subretinal abscess following treatment with intravenous flucloxacillin. A chorioretinal scar swiftly replaced the subfoveal abscess. Peripheral right vision and full left vision was retained. Vision loss due to endogenous endophthalmitis in systemic sepsis is an emergency requiring prompt multidisciplinary care. Sight and life are at risk—thus this is not a diagnosis to miss! Early recognition is paramount to health and in retaining vision. We briefly review relevant literature and portray how multimodal imaging guided response to treatment of acute subretinal abscess.
关键词： endophthalmitis,Staphylococcus aureus septicaemia,multimodal retinal imaging,HIV infection,acute subretinal abscess,latent syphilis
更新于2025-09-04 15:30:14