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Interactive tissue reactions of 1064a??nm focused picoseconda??domain laser and dermal cohesive polydensified matrix hyaluronic acid treatment in in vivo rat skin
摘要： Background: Picosecond-domain laser treatment using a microlens array (MLA) or a diffractive optical element (DOE) generates micro-injury zones in the epidermis and upper dermis. Objective: To investigate interactive tissue reactions between MLA-type picosecond laser pulses and cohesive polydensified matrix hyaluronic acid (CPMHA) filler in the dermis. Methods: In vivo rats with or without CPMHA pretreatment were treated with a 1064-nm picosecond-domain neodymium:yttrium-aluminum-garnet (Nd:YAG) laser using an MLA or DOE. Skin samples were obtained at post-treatment days 1, 10, and 21 and histologically and immunohistochemically analyzed. Results: Picosecond-domain Nd:YAG laser treatment with an MLA-type or a DOE-type handpiece generated fractionated zones of pseudo-cystic cavitation along the lower epidermis and/or upper papillary dermis at Day 1. At Day 21, epidermal thickness, dermal fibroblasts, and collagen fibers had increased. Compared to CPMHA-untreated rats, rats pretreated with CPMHA showed marked increases in fibroblasts and collagen fibers in the papillary dermis. Immunohistochemical staining for the hyaluronic acid receptor CD44 revealed that MLA-type picosecond laser treatment upregulated CD44 expression in the basilar epidermis and dermal fibroblasts. Conclusions: We suggest that the hyaluronic acid-rich environment associated with CPMHA treatment may enhance MLA-type picosecond-domain laser-induced tissue reactions in the epidermis and upper dermis.
关键词： laser,neodymium-doped yttrium aluminum garnet,cohesive polydensified matrix hyaluronic acid,laser-induced tissue breakdown,CD44,picosecond
更新于2025-09-23 15:19:57
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Immediate effect of pulsed high-intensity neodymium-doped yttrium aluminum garnet (Nd: YAG) laser on staphylococcus aureus and pseudomonas aeruginosa growth: an experimental study
摘要： The aim of this study was to evaluate the effect of pulsed high intensity neodymium-doped yttrium aluminum garnet (Nd: YAG) laser on staphylococcus aureus (S. aureus) and pseudomonas aeruginosa (P. aeruginosa) bacterial growth, which cause many health problems and establish which doses are effective in bacterial inhibition. Five samples of S. aureus and five samples of P. aeruginosa were prepared in the microbiology lab, one used as control sample and the other 4 samples acted as experimental samples. The experimental samples received pulsed high intensity Nd: YAG laser with a total dose of 500, 600, 700 and 800 joules. The primary measures are colony count and the percentage decrease in colony count, the colony count was assessed at baseline and after 24 h of laser application. There was significant decrease in colony count and the percentage decrease in colony count after pulsed high intensity Nd: YAG laser application in all experimental samples of S. aureus and P. aeruginosa after 24 h of application for all doses (500, 600, 700 and 800 j) as compared with the control sample, with the most effect in higher doses of pulsed high intensity Nd: YAG laser than lower doses in both types of bacteria. pulsed high intensity Nd: YAG laser was found to be an effective modality for inhibition of S. aureus and P. aeruginosa growth after a single application.
关键词： Bacterial growth,Pulsed high intensity neodymium-doped yttrium aluminum garnet (Nd: YAG) laser,Colony count
更新于2025-09-16 10:30:52
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Successful Treatment of Cosmetic Eyebrow Tattoos in Fitzpatrick III‐IV With Picosecond (1,064, 532‐nm) Neodymium‐Doped Yttrium Aluminum Garnet Laser With a Perfluorodecalin‐Infused Patch: A Pilot Study
摘要： Background and Objectives: Nanosecond Q‐switched lasers have been used for the removal of traditional and cosmetic tattoos. Picosecond lasers utilize pulse durations of 10?12 and provide more efficient clearance of tattoos. Safe and effective removal of tattoos is especially important in cosmetically sensitive areas such as the face. We report four patients with skin types (III–IV) who have had successful removal of eyebrow tattoos with the picosecond (1,064‐, 532‐nm) laser using a perfluorodecalin‐infused patch (PFD). Study Design/Materials and Methods: Patients with eyebrow tattoos underwent treatment with dual‐wavelength picosecond Nd:YAG laser at 1,064‐nm with a 3 mm spot size and fluence of 4–4.6 J/cm2. The 532‐nm wavelength was also used during treatment #1 (patient 2 only) with a 4 mm spot size and fluence of 0.5 J/cm2. Patient 1 had a total of three treatments (6–8 weeks apart). The remaining patients, each had only one treatment. Patients were photographed prior to treatment and subsequently at each follow‐up. Results: Immediately following each laser treatment, only mild and transient localized erythema and edema was observed. Some epidermal crusting was noted for 3–5 days following each treatment. Eyebrow hair growth was not affected and no adverse events were reported. There was 75% clearance in patient 1 after three treatments over a period of 2.5 months, 75% clearance in patient 2 after one treatment, 90% clearance in patient 3 after one treatment, and 100% clearance in patient 4 after one treatment. Conclusions: The 532‐ and 1,064‐nm wavelength of the picosecond Nd:YAG laser was safely used to clear brown and black ink eyebrow tattoos in four patients, three of whom were skin type IV, and one of whom underwent eyebrow tattoo via microblading, a novel and popular technique for cosmetic tattoos. The use of picosecond laser provides several treatment advantages to Q‐switched laser when treating eyebrow tattoos. In our experience, it required less number of treatments and lower fluences. This, along with use of the perfluorodecalin‐infused patch resulted in excellent outcomes for our patients with no significant side effects.
关键词： microblading,Nd:YAG,permanent makeup,picosecond,cosmetic tattoos,eyebrow tattoo,neodymium‐doped yttrium aluminum garnet
更新于2025-09-12 10:27:22