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Nonablative fractional laser therapy for treatment of actinic keratosis with 3a??months followa??up
摘要： Background: Actinic keratosis (AK) is a common skin disorder that is treated with different treatment modalities. Aims: The aim of this study was to assess the therapeutic effect of a 1540-nm non- ablative fractional laser on the AK. Methods: Ten patients with 31 AK were included in the study according to the inclu- sion and exclusion criteria. Treatment with nonablative fractional laser (1540 nm) 3 times at 4 weeks intervals in a noncontact mode was applied. Clinical severity was as- sessed at each session and 3 months after the last session. It is pertinent to mention that the patients were also involved in the assessment of improvement. Results: The results of present study showed that in comparison to the baseline, 3-session AK therapy with nonablative fractional laser significantly not only im- proved the AK severity by 79%, but also reduced the AK counts (from 31 to 17). On the other hand, the patients consented to the therapeutic effect. Conclusion: According to the obtained results and available studies, it seems that therapy with a 1540-nm nonablative fractional laser could be considered as a safe and effective alternative therapeutic option for the treatment of AK.
关键词： actinic keratosis,nonablative fractional laser
更新于2025-09-16 10:30:52
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1550-nm Nonablative Fractional Laser Versus 10,600-nm Ablative Fractional Laser in the Treatment of Surgical and Traumatic Scars
摘要： BACKGROUND The appearance and symptoms of scars can cause significant distress to patients. OBJECTIVE To assess and compare efficacy of the 1,500-nm nonablative fractional laser (NAFL) and 10,600-nm ablative fractional laser (AFL) in reducing symptoms and improving the appearance of traumatic or surgical scars. MATERIALS AND METHODS Single-center prospective, randomized, blinded, split-scar study was conducted on 100 patients with a scar obtained through trauma or surgery. Three treatments of NAFL or AFL were administered to each half of the scar at 4-week intervals. Scars were self-rated by the patient using the Patient and Observer Scar Assessment Scale and a satisfaction score and objectively evaluated by blinded dermatologists using the Manchester Scar Scale and visual analog scale. RESULTS Blinded observers found no statistically significant difference in scar appearance. Patient rating showed improvement of scar appearance (p < .0001). Pain was worse after treatment with AFL (p = .0492). Overall, there was no statistically significant evidence of one laser being superior or inferior to the other for patient and blinded observer scores (p = .3173 and p = .2513, respectively). CONCLUSION Scar treatment with AFL or NAFL is associated with high patient satisfaction. Objective evaluation of scars did not identify improvement in scar appearance.
关键词： efficacy,treatment regimen,10,550-nm nonablative fractional laser,scar treatment,1,600-nm ablative fractional laser
更新于2025-09-12 10:27:22
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Laser-Assisted Delivery of Topical Rapamycin
摘要： Birt–Hogg–Dube syndrome (BHDS) is a genodermatosis that presents with multiple adnexal tumors (fibrofolli- culomas and trichodiscomas) and has increased suscep- tibility for renal tumors, pulmonary cysts, and spontaneous pneumothorax. No specific treatment exists for the cutaneous lesions of BHDS, and ablative laser therapies have only demonstrated modest results with relapse after 6 months. We present a patient with BHDS whose fibrofolliculomas were successfully treated with topical rapamycin and nonablative fractional laser.
关键词： Birt–Hogg–Dube syndrome,mTOR inhibition,fibrofolliculomas,nonablative fractional laser,topical rapamycin
更新于2025-09-12 10:27:22
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Nonablative Fractional 1,550-nm Laser for the Treatment of an Unusual Nevus Sebaceus
摘要： Nevus sebaceus is a benign congenital neoplasm that presents as a hairless yellow, waxy thin plaque on the scalp or face. Initially asymptomatic, the nevus sebaceus often becomes verrucous during puberty prompting evaluation by a dermatologist. Historically, the mainstay of treatment was prophylactic surgical excision due to the potential for malignant transformation; however, the literature has now demonstrated that the incidence of developing a malignancy within a nevus sebaceous is actually quite low at approximately 1%. Currently, there is a lack of consensus regarding the optimal management of nevus sebaceus, and less-invasive approaches are being explored. In this article, we report a case of an unusual nevus sebaceus treated successfully with a nonablative fractional 1,550-nm laser.
关键词： nevus sebaceus,dermatology,nonablative fractional laser,treatment
更新于2025-09-12 10:27:22