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Dosimetric evaluation of an atlas-based synthetic CT generation approach for MR-only radiotherapy of pelvis anatomy
摘要： Purpose: To investigate the potential of an atlas‐based approach in generation of synthetic CT for pelvis anatomy. Methods: Twenty‐three matched pairs of computed tomography (CT) and magnetic resonance imaging (MRI) scans were selected from a pool of prostate cancer patients. All MR scans were preprocessed to reduce scanner‐ and patient‐induced intensity inhomogeneities and to standardize their intensity histograms. Ten (training dataset) of 23 pairs were then utilized to construct the coregistered CT‐MR atlas. The synthetic CT for a new patient is generated by appropriately weighting the deformed atlas of CT‐MR onto the new patient MRI. The training dataset was used as an atlas to generate the synthetic CT for the rest of the patients (test dataset). The mean absolute error (MAE) between the deformed planning CT and synthetic CT was computed over the entire CT image, bone, fat, and muscle tissues. The original treatment plans were also recomputed on the new synthetic CTs and dose–volume histogram metrics were compared. The results were compared with a commercially available synthetic CT Software (MRCAT) that is routinely used in our clinic. Results: MAE errors (±SD) between the deformed planning CT and our proposed synthetic CTs in the test dataset were 47 ± 5, 116 ± 12, 36 ± 6, and 47 ± 5 HU for the entire image, bone, fat, and muscle tissues respectively. The MAEs were 65 ± 5, 172 ± 9, 43 ± 7, and 42 ± 4 HU for the corresponding tissues in MRCAT CT. The dosimetric comparison showed consistent results for all plans using our synthetic CT, deformed planning CT and MRCAT CT. Conclusion: We investigated the potential of a multiatlas approach to generate synthetic CT images for the pelvis. Our results demonstrate excellent results in terms of HU value assignment compared to the original CT and dosimetric consistency.
关键词： synthetic CT,pelvis anatomy,generalized registration error,bone- and fat-suppressed CT
更新于2025-09-23 15:23:52
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Integration of spectroscopy and imaging to optimize evaluation of voiding dysfunction
摘要： Voiding dysfunction occurs due to the interplay of anatomic, physiologic and functional elements. Hence, integration of new imaging and spectroscopy modalities offers the potential for improving patient assessment by enabling the causal structural defects, formal staging of pelvic floor dysfunction and underlying physiologic mechanisms to be better defined. The purpose of this review is to outline the limitations of current imaging, and highlight the advantages of newer technologies in the evaluation of patients with voiding dysfunction due to loss of structural integrity of the pelvic floor.
关键词： fMRI,pelvis,MRI,prolapse,voiding dysfunction,fNIRS,NIRS,MRO
更新于2025-09-19 17:15:36