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A Water-soluble, NIR-absorbing Quaterrylenediimide Chromophore for Photoacoustic Imaging and Efficient Photothermal Cancer Therapy
摘要： Precision phototheranostics, including photoacoustic imaging and photothermal therapy, requires stable photothermal agents. Developing photothermal agents with high stability and high photothermal conversion efficiency (PTCE) remains a considerable challenge in biomedical applications. Herein, we introduce a new photothermal agent based on water-soluble quaterrylenediimide (QDI) that can self-assemble into nanoparticles (QDI-NPs) in aqueous solution. Incorporation of polyethylene glycol (PEG) into the QDI core significantly enhances both physiological stability and biocompatibility of QDI-NPs. These highly photostable QDI-NPs exhibit exciting advantages including intense absorption in the near-infrared (NIR) and high PTCE of up to 64.7 ± 4%. This is higher than that of many other organic photothermal agents, such as graphene or commercial indocyanine green (ICG). Their small size of approximately 10 nm enables a sustained retention in deep tumor sites and at the same time proper clearance from the body. QDI-NPs allow high-resolution photoacoustic imaging and efficient 808 nm laser-triggered photothermal therapy of cancer in vivo. The current study opens a promising way for precision phototheranostics.
关键词： quaterrylenediimide,photoacoustic imaging,NIR-absorption,pharmacokinetics,photothermal conversion efficiency
更新于2025-09-09 09:28:46
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A Water-soluble, NIR-absorbing Quaterrylenediimide Chromophore for Photoacoustic Imaging and Efficient Photothermal Cancer Therapy
摘要： Precision phototheranostics, including photoacoustic imaging and photothermal therapy, requires stable photothermal agents. Developing photothermal agents with high stability and high photothermal conversion efficiency (PTCE) remains a considerable challenge in biomedical applications. Herein, we introduce a new photothermal agent based on water-soluble quaterrylenediimide (QDI) that can self-assemble into nanoparticles (QDI-NPs) in aqueous solution. Incorporation of polyethylene glycol (PEG) into the QDI core significantly enhances both physiological stability and biocompatibility of QDI-NPs. These highly photostable QDI-NPs exhibit exciting advantages including intense absorption in the near-infrared (NIR) and high PTCE of up to 64.7 ± 4%. This is higher than that of many other organic photothermal agents, such as graphene or commercial indocyanine green (ICG). Their small size of approximately 10 nm enables a sustained retention in deep tumor sites and at the same time proper clearance from the body. QDI-NPs allow high-resolution photoacoustic imaging and efficient 808 nm laser-triggered photothermal therapy of cancer in vivo. The current study opens a promising way for precision phototheranostics.
关键词： quaterrylenediimide,photoacoustic imaging,NIR-absorption,pharmacokinetics,photothermal conversion efficiency
更新于2025-09-09 09:28:46