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Synergistic Effects of Photo-Irradiation and Curcumin-Chitosan/Alginate Nanoparticles on Tumor Necrosis Factor-Alpha-Induced Psoriasis-Like Proliferation of Keratinocytes
摘要： Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of the epidermal cells and is clinically presented as thick, bright red to pink plaques with a silvery scale. Photodynamic therapy (PDT) using visible light has become of increasing interest in the treatment of inflammatory skin diseases. In this study, we demonstrate that a combination of curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) and blue light emitting diodes (LED) light irradiation effectively suppressed the hyperproliferation of tumor necrosis factor-alpha (TNF-α)-induced cultured human kerlatinocyte (HaCaT) cells. The Cur-CS/Alg NPs were fabricated by emulsification of curcumin in aqueous sodium alginate solution and ionotropic gelation with calcium chloride and chitosan using an optimized formulation derived from a Box-Behnken design. The fabricated Cur-CS/Alg NPs were characterized for their particle size, zeta potential, encapsulation efficiency, and loading capacity. The surrogate 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, to measure the relative number of viable cells, showed that the CS/Alg NPs were nontoxic to normal HaCaT cells, while 0.05 μg/mL and 0.1 μg/mL of free curcumin and Cur-CS/Alg NPs inhibited the hyperproliferation of HaCaT cells induced by TNF-α. However, the Cur-CS/Alg NPs demonstrated a stronger effect than the free curcumin, especially when combined with blue light irradiation (10 J/cm2) from an LED-based illumination device. Therefore, the Cur-CS/Alg NPs with blue LED light could be potentially developed into an effective PDT system for the treatment of psoriasis.
关键词： LED light,chitosan/alginate nanoparticles,curcumin,photo-irradiation,psoriasis
更新于2025-11-19 16:56:35
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Effect of photo-irradiation on metal insulator transition in vanadium dioxide
摘要： We report a large transition temperature (TC) decrease in a VO2 thin film device under photo-irradiation. With the increasing photo-irradiation intensity (PIntensity) with a wavelength of 405 nm, the TC of the VO2 device decreased at a rate of (cid:2)3:2 (cid:3) 10(cid:4)2 W=cm2 and reached as low as 40.0 (cid:5)C at a PIntensity of 8:4 (cid:3) 102 W=cm2. While the change in TC is primarily due to the photothermal effect when the PIntensity is below 3:6 (cid:3) 102 W=cm2, both the photothermal and photo-induced carrier density effects contribute to the change in TC when the PIntensity is above 6:4 (cid:3) 102 W=cm2.
关键词： metal-insulator transition,vanadium dioxide,photothermal effect,photo-induced carrier density,photo-irradiation
更新于2025-09-23 15:21:21
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Photoinduced Regulation of the Heat Resistance in Polymer Networks with Diarylethene-Conjugated Reversible Covalent Cross-Links
摘要： A cross-linker with a diarylethene-conjugated Diels?Alder adduct (DAE/DA) was synthesized and applied in a radical polymerization system to afford polymer networks whose dynamic nature can be changed reversibly by photo-irradiation. Free-radical polymerization of hexyl methacrylate and the DAE/DA-based cross-linker furnished an insoluble and transparent poly(hexyl methacrylate) network with DAE/DA moieties at their cross-linking points, which undergo de-cross-linking via a thermally induced retro-DA reaction upon heating. The photoregulation of such a thermal de-cross-linking reaction in DAE/DA-based polymer networks was demonstrated by swelling experiments and tensile tests, revealing drastic changes in the heat resistance and mechanical properties upon exposure to UV?vis irradiation.
关键词： heat resistance,mechanical properties,polymer networks,diarylethene,photo-irradiation,Diels?Alder adduct
更新于2025-09-23 15:19:57