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A comprehensive approach for characterisation of the deposited energy density during laser-matter interaction in liquids and solids
摘要： We present a novel approach for characterisation of ultrafast laser-matter interaction processes both in solids and liquids under extreme conditions of microplasma generation. By combination of three-dimensional propagation imaging, absorption measurements, shadowgraphy and photoacoustic imaging we can restore plasma electron density distribution, laser pulse fluence profile and the value of deposited energy density inside the bulk of the material and characterise the regime of the laser pulse propagation. The developped concept is important to understand the physics of ultrafast laser-matter interaction with strong implications for precision control of laser micromachining, bioprocessing and biotreatment.
关键词： three-dimensional propagation imaging,photoacoustics,femtosecond filamentation,laser-matter interaction,deposited energy density,shadowgraphy
更新于2025-09-23 15:21:01
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[IEEE 2019 IEEE International Ultrasonics Symposium (IUS) - Glasgow, United Kingdom (2019.10.6-2019.10.9)] 2019 IEEE International Ultrasonics Symposium (IUS) - Non-Contact laser ultrasound (N-CLUS) system for medical imaging and elastography
摘要： MIT Lincoln Laboratory, the Medical Device Realization Center (MEDRC) at MIT, and the Massachusetts General Hospital (MGH) are collaboratively developing a novel optical system that acquires ultrasound images within the human body without physical contact to the patient. The system is termed, non-contact laser ultrasound (N-CLUS) and yields anatomical images in tissue and bone and can also measure elastographic properties, in-vivo, all from an operational standoff of a few inches to several meters as desired. N-CLUS employs a pulsed laser that converts optical energy into ultrasonic waves at the skin surface via photoacoustic mechanisms, while, a laser Doppler vibrometer measures reflected-emerging ultrasonic waves from tissue at depth at the skin surface. The key of the N-CLUS approach is driven by shallow optical absorptivity that creates an acoustic source that enables ultrasound propagation deeper into the tissue. We discuss the motivation of the non-contact laser concept, its development path involving signal generation, skin and eye safe laser measurement, and system design perspectives. Elastogrphic measurements are then demonstrated with determination of bone elastic moduli for beef rib within tissue. N-CLUS images from soft tissue specimens are also compared with commercial ultrasound, showing that the noncontact optical approach may have potential as a viable method in medical ultrasound.
关键词： laser Doppler vibrometry,photoacoustics,non-contact laser ultrasound,medical ultrasound imaging,elastography
更新于2025-09-16 10:30:52
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Photoacoustic Identification of Laser-induced Microbubbles as Light Scattering Centers for Optical Limiting in Liquid Suspension of Graphene Nanosheets
摘要： Liquid suspensions of carbon nanotubes, graphene and transition metal dichalcogenides have exhibited excellent performance in optical limiting. However, the underlying mechanism has remained elusive and is generally ascribed to their superior nonlinear optical properties such as nonlinear absorption or nonlinear scattering. Using graphene as an example, we show that photo-thermal microbubbles are responsible for the optical limiting as strong light scattering centers: graphene sheets absorb incident light and become heated up above the boiling point of water, resulting in vapor and microbubble generation. This conclusion is based on direct observation of bubbles above the laser beam as well as a strong correlation between laser-induced ultrasound and optical limiting. In-situ Raman scattering of graphene further confirms that the temperature of graphene under laser pulses rises above the boiling point of water but still remains too low to vaporize graphene and create graphene plasma bubbles. Photo-thermal bubble scattering is not a nonlinear optical process and requires very low laser intensity. This understanding helps us to design more efficient optical limiting materials and understand the intrinsic nonlinear optical properties of nanomaterials.
关键词： Raman,photoacoustics,bubble scattering,graphene,optical limiting
更新于2025-09-16 10:30:52
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Full noncontact laser ultrasound: first human data
摘要： Full noncontact laser ultrasound (LUS) imaging has several distinct advantages over current medical ultrasound (US) technologies: elimination of the coupling mediums (gel/water), operator-independent image quality, improved repeatability, and volumetric imaging. Current light-based ultrasound utilizing tissue-penetrating photoacoustics (PA) generally uses traditional piezoelectric transducers in contact with the imaged tissue or carries an optical fiber detector close to the imaging site. Unlike PA, the LUS design presented here minimizes the optical penetration and specifically restricts optical-to-acoustic energy transduction at the tissue surface, maximizing the generated acoustic source amplitude. With an appropriate optical design and interferometry, any exposed tissue surfaces can become viable acoustic sources and detectors. LUS operates analogously to conventional ultrasound but uses light instead of piezoelectric elements. Here, we present full noncontact LUS results, imaging targets at ~5 cm depths and at a meter-scale standoff from the target surface. Experimental results demonstrating volumetric imaging and the first LUS images on humans are presented, all at eye- and skin-safe optical exposure levels. The progression of LUS imaging from tissue-mimicking phantoms, to excised animal tissue, to humans in vivo is shown, with validation from conventional ultrasound images. The LUS system design insights and results presented here inspire further LUS development and are a significant step toward the clinical implementation of LUS.
关键词： photoacoustics,noncontact imaging,volumetric imaging,human imaging,laser ultrasound
更新于2025-09-12 10:27:22
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“Guide Star” Assisted Noninvasive Photoacoustic Measurement of Glucose
摘要： A novel “guide star” assisted photoacoustic (GSPA) method for noninvasive glucose measurement has been proposed. Instead of receiving PA signals that are directly generated by tissue, a virtual photodiode is employed to amplify the PA signal difference regarding amplitude and peak arrival time caused by glucose concentration variations in an indirect way. Being different from traditional PA spectroscopy, this method can improve sensitivity and accuracy by optimizing optical path lengths (or tissue thickness). On the other hand, being superior to near-infrared (NIR) spectroscopy, it utilizes both optical absorption and acoustic propagation velocity information offered by PA signals. Theoretical analysis and simulation have been done to illustrate how the concentration change affects the PA waveform. In vitro experiments on aqueous glucose solution were conducted with concentrations varying in human physiological range (50~350 mg/dL). Performance of quartz cuvettes with 1-mm and 2-mm optical path lengths were compared in terms of correlation quality (R2), degree of agreement (Bland-Altman plot) and clinical accuracy (Clarke’s Error Grid analysis) to demonstrate the scalability of sensitivity provided by the indirect method. Longer optical length shows better sensitivity and accuracy in this case. Moreover, detection was also done on human blood serum to further prove the potential of the proposed method for clinical application. Our proposed method provides solution to enhance sensitivity, facilitating development of portable and low-cost PA sensors with low power laser diodes for noninvasive glucose monitoring and other applications.
关键词： near-infrared,photoacoustics,virtual photodiode,noninvasive glucose monitoring,Diabetes Mellitus
更新于2025-09-09 09:28:46