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Photobiomodulation Therapy is Able to Modulate PGE <sub/>2</sub> Levels in Patients With Chronic Nona??Specific Low Back Pain: A Randomized Placeboa??Controlled Trial
摘要： Background and Objectives: Non‐specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of inflammatory mediators’ levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory mediators’ levels and pain intensity in patients with chronic non‐specific LBP. Study Design/Materials and Methods: A prospectively registered, randomized triple‐blinded (volunteers, therapists, and assessors), placebo‐controlled trial was performed. Eighteen patients with chronic non‐specific LBP were recruited and treated with a single session of active PBMT or placebo PBMT. The primary outcome of the study was serum prostaglandin E2 levels and the secondary outcomes were tumor necrosis factor‐α, interleukin‐6 levels, and pain intensity. All outcomes were measured before and after 15 minutes of treatment session. Results: PBMT was able to decrease prostaglandin E2 levels at post‐treatment compared with placebo, with a mean difference of ?1470 pg/ml, 95% confidence interval ?2906 to ?33.67 in patients with LBP. There was no difference between groups in the other measured outcomes. Patients did not report any adverse events. Conclusion: Our results suggest that PBMT was able to modulate prostaglandin E2 levels, indicating that this may be one of the mechanisms involved in the analgesic effects of PBMT in patients with LBP.
关键词： low‐level laser therapy,inflammatory mediators,low back pain,physical therapy,rehabilitation,musculoskeletal disorders
更新于2025-09-23 15:19:57
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Acute effects of photobiomodulation therapy applied to respiratory muscles of chronic obstructive pulmonary disease patients: a double-blind, randomized, placebo-controlled crossover trial
摘要： To investigate the effects of photobiomodulation applied to respiratory muscles on lung function, thoracoabdominal mobility, respiratory muscle strength, and functional capacity in COPD patients. This is a randomized double-blind crossover clinical trial. Twelve male COPD patients participated in the study. Participants were randomly allocated to receive two photobiomodulation sessions, 1 week apart: (1) an effective photobiomodulation session applied at the main respiratory muscles by means of a cluster with 69 light-emitting diodes (LEDs), containing 35 red (630 ± 10 nm; 10 mW; 0.2 cm2) and 34 near-infrared (830 ± 20 nm; 10 mW; 0.2 cm2) LEDs and (2) a sham photobiomodulation session, following the same procedures without emitting light. The primary outcomes were pulmonary function (spirometric indexes); thoracoabdominal mobility (cirtometry); respiratory muscle strength (maximal respiratory pressures), assessed at three moments: (1) baseline, (2) 1 h after intervention, and (3) 24 h after intervention; and the functional capacity, assessed by the 6-min walk test (6MWT) at baseline and 24 h after intervention. No significant interactions were found for spirometric variables, maximal respiratory pressures, and cirtometry. However, there was a Time × Condition interaction (F = 18.63; p = 0.001; η2 p = 0.62) in the walked distance on the 6MWT, with a significant increase after photobiomodulation intervention (p < 0.01) compared with the baseline. Photobiomodulation applied to respiratory muscles was effective in improving acute functional capacity in COPD patients. To the best of our knowledge, this is the first study assessing the effects of photobiomodulation applied to respiratory muscles in patients with COPD.
关键词： Physical therapy,Phototherapy,Respiratory function tests,Low-level light therapy,6-min walk test
更新于2025-09-19 17:13:59
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Effect of Laser Therapy on Swelling, Pain, and Range of Motion in Patients with Breast Cancer-related Lymphedema: A Systematic Review & Meta-analysis
摘要： A systematic review was performed through 11 relevant databases. Studies that pertained to pediatric cancer and the effects of physical therapy intervention which were published between the years 2000-2013 were included in this review. Each article was assessed using the AACPDM systematic review tool by four separate researchers. Summary of Use: Patients who undergo treatment for pediatric cancers show an increase in both short and long term impairments, functional problems, and adverse quality of life compared with healthy individuals. These aspects include long term cardiac dysfunction, decreased ankle DF AROM, decreased balance proficiency, decreased function, and decreased in certain aspects of health related quality of life. Physical therapy demonstrates effectiveness in addressing short and long term impairments, functional problems, and decreased quality of life in patients with pediatric neoplasm. Improved scores were shown for knee extension strength as well as scores comparable to healthy controls for ankle dorsiflexion strength. Functional tests such as Timed Up and Down Stairs (TUDS) and 9 minute run-walk test also showed values comparable to healthy controls. This systematic search produced little evidence that demonstrated the optimal time during the cancer treatment course to address impairments, functional limitations, and decreased quality of life. One study produced in our search showed improvements in pediatric cancer patients with concurrent physical therapy intervention. While physical therapy has been shown to effectively treat these issues with feasible interventions for appropriate patients, therapy services are still underutilized in all settings. Importance to Members: This review presents significant information that can be applied to practicing clinicians. Musculoskeletal dysfunction and decreased quality of life are common findings both during and following treatment for pediatric cancers. Although physical therapy has been adequately shown to modulate the physical effects of pediatric cancer treatment, there are still few studies conducted regarding optimal timing and the long term benefit of physical therapy intervention. Therefore, more in depth research should be performed in order to validate current findings on the outcome of physical therapy intervention relating to its positive impact on impairments, functional limitations and quality of life in patients that are undergoing treatment for pediatric cancer.
关键词： pediatric cancer,physical therapy
更新于2025-09-16 10:30:52