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- PIN diode
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- multifunctional AFSS (MAFSS)
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- surface wave enhanced fluorescence
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- Optoelectronic Information Science and Engineering
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- Ufa State Aviation Technical University
- Chung-Ang University
- BMS College of Engineering
- Fraunhofer Institute for Applied Optics and Precision Engineering IOF
- Sapienza University
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- Karnataka Institute of Endocrinology and Research (KIER)
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Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression
摘要： Gold nanoparticles (GNPs) are usually wrapped with biocompatible polymers in biomedical field, however, the effect of biocompatible polymers of gold nanoparticles on cellular responses are still not fully understood. In this study, GNPs with/without polymer wrapping were used as model probes for the investigation of cytotoxicity and cell cycle progression. Our results show that the bovine serum albumin (BSA) coated GNPs (BSA-GNPs) had been transported into lysosomes after endocytosis. The lysosomal accumulation had then led to increased binding between kinesin 5 and microtubules, enhanced microtubule stabilization, and eventually induced G2/M arrest through the regulation of cadherin 1. In contrast, the bare GNPs experienced lysosomal escape, resulting in microtubule damage and G0/G1 arrest through the regulation of proliferating cell nuclear antigen. Overall, our findings showed that both naked and BSA wrapped gold nanoparticles had cytotoxicity, however, they affected cell proliferation via different pathways. This will greatly help us to regulate cell responses for different biomedical applications.
关键词： surface biocompatibility,microtubule,proteomics,nanoparticle location,cell cycle
更新于2025-09-04 15:30:14
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[Institution of Engineering and Technology 12th European Conference on Antennas and Propagation (EuCAP 2018) - London, UK (9-13 April 2018)] 12th European Conference on Antennas and Propagation (EuCAP 2018) - Metallic Metasurface Antennas for Space
摘要： In metasurface (MTS) antennas, a surface-wave (SW) is gradually radiated by modulating an equivalent reactance tensor in the aperture plane. Such modulation results in the (-1) indexed Floquet mode entering the visible region, thus becoming a leaky-wave (LW) mode with curvilinear phase-contour. This paper explores the use of a class of metallic MTS in the synthesis of the reactance tensor required to obtain the objective radiation patterns. The absence of dielectric is useful to survive harsh environments in space exploration. The proposed element consists of a metallic cylinder with elliptical cross-section, placed on a ground plane and arranged in a square lattice with sub-wavelength unit-cell side. We have applied this structure in the design of a right-handed circularly polarized antenna, with a broadside pencil beam in the Ka band. The obtained performance has been veri?ed by full-wave simulations. A prototype has been manufactured and measurements will be available at the time of the conference.
关键词： surface waves,leaky waves,metasurfaces,circular polarization,millimeter waves,Ka band
更新于2025-09-04 15:30:14
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Surface-Plasmon Assisted Transmission Through an Ultrasmall Nanohole of ~ 10 nm with a Bull’s Eye Groove
摘要： We simulate the light transmission through an extremely small nanoscale aperture having a 10 nm diameter punctured in a metal ?lm positioned at the center of a plasmonic bull’s eye grating. A considerable directive emission of transmitted light with a divergence angle of 5.7 degrees was observed at 10 μm from the nanohole opening at the frequency of surface plasmon polariton excitation, an con?rmed by measuring the distance dependent transmission amplitude. Observations of the electric ?eld in cross-sectional, near-?eld, and far-?eld views near-?eld enhancement associated with the surface plasmon excitation, and the interference of the electric ?eld light through the nanohole in the near-?eld region is responsible for such a considerable directive emission.
关键词： Plasmons on surface and interface,Optical di?raction,Optical properties of nanostructures
更新于2025-09-04 15:30:14