- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis
摘要： Purpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results. Significant macular thinning was observed in all ETDRS areas (p < 0.001) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors (p < 0.001) except in the nasal quadrant/sector (p > 0.05). GCL+ measurements were found to be reduced in the nasal (p = 0.003), inferonasal (p = 0.045), and temporal (p = 0.001) sectors and total thickness (p < 0.001). Choroidal thickness was reduced in the outer macular ring in MS patients compared with controls (p = 0.038). Conclusion. New swept-source technology for OCT devices detects retinal thinning in MS patients, providing increased depth analysis of the choroid in these patients. MS patients present reduced retinal and choroidal thickness in the macular area and reduced peripapillary retinal, RNFL, and GCL thickness.
关键词： ganglion cell layer,choroidal thickness,retinal thickness,retinal nerve fiber layer,swept-source optical coherence tomography,multiple sclerosis
更新于2025-09-04 15:30:14
-
Effect of Anodization Parameters on the Surface Morphology and Photoelectrochemical Properties of TiO2 Nanotubes
摘要： Titanium sheets are anodized to prepare titanium dioxide nanotubes (TiO2 NTs) with varying chemical polishing times, anodizing voltages, anodizing times and NH4F electrolyte concentrations. The surface morphology of the TiO2 NTs is observed by a Scanning Electron Microscope (SEM) and used to characterize the inner diameter (di), centre to centre distance (l) and wall thickness (w). The photoelectrochemical performance of TiO2 NT arrays is described by measurements of the photocurrent density and the incident photon to current efficiency (IPCE). The data show l can be controlled by the anodizing voltage; in contrast, di and w are influenced by the anodizing time and NH4F electrolyte concentration. Furthermore, the effects of the anodization parameters on the TiO2 NTs’ surface morphology were determined to influence each other. Using the optimum condition of an anodizing voltage of 60 V at 60 min in 0.125 mass % NH4F ethylene glycol, TiO2 NTs were fabricated that showed a photocurrent density of 90.42 μA /cm2 and maximum IPCE of 18.76 % at 300 nm. The results indicate that the effects of the anodization parameters on the photocurrent response of TiO2 NTs are primarily achieved through control of the wall thickness and the ratio of the diameter to the wall thickness (di / w). For a wall thickness that is greater than a critical value, the ratio di / w can reach a range in which the TiO2 NTs show a high photocurrent output.
关键词： surface morphology,wall thickness,TiO2 nanotubes,anodization,photoelectrochemical property
更新于2025-09-04 15:30:14
-
Spectral domain optical coherence tomography as an adjunctive tool for screening Beh?et uveitis
摘要： Background This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behc?et uveitis in the absence of macular edema (ME). Methods This retrospective, interventional study included a total 131 treatment-na?ve Behc?et patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). The patients were classified according to the anatomical classification of Behc?et uveitis. The main outcome measure was comparison of mean CMT and MV with the types of Behc?et uveitis. Results Sixty patients (45.8%) with no uveitis, 41 patients (31.3%) with anterior uveitis, 18 patients (13.7%) with posterior uveitis, and 12 patients (9.2%) with panuveitis. The mean CMT were 261.6±22.2 μm in no uveitis, 268.1±17.8 μm in anterior uveitis, 306.4±32.9 μm in posterior uveitis, and 300.4±44.0 μm in panuveitis (P < 0.001). The mean MV was 8.7±0.3 mm3 in those without uveitis, 8.8±0.3 mm3 in anterior uveitis, 9.9±1.1 mm3 in those with posterior uveitis, and 9.7±0.4 mm3 in panuveitis (P < 0.001). Types of Behc?et uveitis was the only significant factor correlated with the mean CMT (B = 18.170, β = 0.408, P < 0.001) and the mean MV (B = 0.328, β = 0.652, P < 0.001). Conclusions The mean CMT and MV were significantly thicker in the Behc?et uveitis with posterior involvement. SD OCT can be used for an adjunctive tool for screening Behc?et uveitis, especially for the presence of posterior involvement.
关键词： Behc?et uveitis,macular volume,posterior involvement,spectral domain optical coherence tomography,central macular thickness
更新于2025-09-04 15:30:14
-
Macular Inner Retinal Layer Thickness in Relation to Photopic and Mesopic Contrast Sensitivity in Healthy Young and Older Subjects
摘要： PURPOSE. To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes. METHODS. Measurements were made in 38 young and 38 older healthy individuals. Total, inner, layer (IRL) thicknesses were measured in the macula region through and outer retinal spectral-domain optical coherence tomography (SD-OCT) across three sub?elds, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve ?ber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 108 visual ?eld were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis. RESULTS. Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P ? 0.001) in the young group and of photopic (P ? 0.026) and mesopic CS (P ? 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were signi?cantly different for pair-wise comparisons of both photopic CS and age group (P ? 0.0001) and mesopic CS (P ? 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS. CONCLUSIONS. Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.
关键词： contrast sensitivity,optical coherence tomography,retinal ganglion cells,macular inner retinal layer thickness,mesopic vision,glial cells
更新于2025-09-04 15:30:14
-
Cloud information content analysis of multi-angular measurements in the oxygen A-band: application to 3MI and MSPI
摘要： Information content analyses on cloud top altitude (CTOP) and geometrical thickness (CGT) from multi-angular A-band measurements in the case of monolayer homogeneous clouds are conducted. In the framework of future multi-angular radiometer development, we compared the potential performances of the 3MI (Multi-viewing, Multi-channel and Multi-polarization Imaging) instrument developed by EUMETSAT, which is an extension of POLDER/PARASOL instrument and MSPI (Multiangle SpectroPolarimetric Imager) developed by NASA’s Jet Propulsion Laboratory. Quantitative information content estimates were realized for thin, moderately opaque and opaque clouds for different surface albedo and viewing geometry configurations. Analyses show that retrieval of CTOP is possible with a high accuracy in most of the cases investigated. Retrieval of CGT is also possible for optically thick clouds above a black surface, at least when CGT > 1–2 km and for thin clouds for CGT > 2–3 km. However, for intermediate optical thicknesses (COT (cid:39) 4), we show that the retrieval of CGT is not simultaneously possible with CTOP. A comparison between 3MI and MSPI shows a higher information content for MSPI’s measurements, traceable to a thinner filter inside the oxygen A-band, yielding higher signal-to-noise ratio for absorption estimation. Cases of cloud scenes above bright surfaces are more complex but it is shown that the retrieval of CTOP remains possible in almost all situations while the information content on CGT appears to be insufficient in many cases, particularly for COT < 4 and CGT < 2–3 km.
关键词： multi-angular measurements,cloud geometrical thickness,oxygen A-band,MSPI,3MI,cloud top altitude
更新于2025-09-04 15:30:14
-
Observed Dramatically Improved Catalysis of Ag Shell on Au/Ag Core-Shell Nanorods is Due to Silver Impurities Released During Etching Process
摘要： Core/shell bimetallic nanoparticles are highly popular in electrocatalysis; it is argued that the core metal enhances the catalytic properties of the shell. We have investigated the electrocatalytic properties of Au/Ag core-shell nanorods (Au/Ag NRs) where Ag shell was thinned by aging in the presence of cetyltrimethylammonium bromide. We observed excellent electrocatalysis toward hydrogen peroxide electroreduction upon decreasing the Ag shell thickness, which would, at first, appear to imply a strong synergistic effect of the Au core with the Ag shell for electrocatalysis. We show, however, that this electrocatalysis is not caused by particular Au/Ag core/shell structures but rather by the presence of residual silver impurities in the form of Ag nanoparticles (Ag NPs) formed during the preparation of the thin-layer silver shell/gold core nanorods.
关键词： bimetallic particles,Au/Ag nanorods,varied shell thickness,physicochemical transformation,hydrogen peroxide catalyst
更新于2025-09-04 15:30:14
-
Retinal and Optic Disc Alterations in Alzheimer ’s Disease: the Eye as a Potential Central Nervous System Window
摘要： Pathologic changes in the retina and optic nerve are observed in patients with Alzheimer′s disease (AD), even in early stages of the dementia. In our clinical ophthalmology practice, we use optical coherence tomography (OCT), a noninvasive, rapid, objective, and reliable technology that enables for quantification of the retinal nerve fiber layer (RNFL), namely the retinal ganglion cell axons that eventually form the optic nerve. The opportunity to analyze a part of the central nervous system by such a simple exploration led to several studies demonstrating thinning of the RNFL and central retina in AD patients compared with healthy subjects. Here we present some of our investigations in AD patients using Spectral Domain-OCT. Our results suggest that axonal loss secondary to pathologic alterations in the brains of AD patients can be observed by OCT. We also analyzed the association between retinal and RNFL thicknesses and neurologic characteristics, disease duration and severity, and found that mean RNFL thickness was significantly correlated with disease duration, indicating that the progression of AD is associated with a progressive loss of ganglion cells.
关键词： Retinal nerve fiber layer,Retinal thickness,Optic disc,Optical coherence tomography,Alzheimer’s disease
更新于2025-09-04 15:30:14
-
Progressive Visusminderung bei Zapfendystrophie. Spurensuche im Makula-OCT und Multifokal-ERG; Progressive loss of vision in cone dystrophy. Search for evidence with macular OCT and multifocal ERG;
摘要： A 53-year-old patient consulted our practice clinic complaining of progressive visual loss, increased glare sensitivity and color sense disorder. Extensive diagnostic investigation, including multifocal ERG (mfERG) and macular thickness map with the help of optical coherence tomography (OCT), supported the suspected diagnosis of a cone dystrophy. There are, however, no established therapeutic options. A diagnostic confirmation by means of molecular genetics was not successful.
关键词： Molecular genetics,Central scotoma,Glare sensitivity,Macular thickness map,Color sense disorder
更新于2025-09-04 15:30:14
-
Evaluation of Each Retinal Layer Thickness According to Preoperative OCT Patterns after Idiopathic ERM Removal
摘要： ??: ??? ???????? ? ? ????????? ???? ??? ?? ?? ?? ???? ????? ??? ??? ????, ?????? ????? ????? ???. ??? ??: ??? ?????? ??? ?? 6?? ?? ????? ???? ?? 63? 63?? ???? ????? ?????. ? ? ???????? ?? ????? ??? ???, ???, ????? ???? ?? ?? ???? ????? ??? ??? ????, ?????? ????? ??? ???. ??: ? ? ??? ???, ???, ??? ????, ?????? ??? ????? ???. ???? ?? ? ? ? ??????+????, ????, ?????? ???, ???, ??? ??? ??? ????? ???, ? ? ??????+????? ?????? ???, ???, ??? ??? ????? ??? ??? ???. ? ? ??? ???? ??? ? ? ???? ???, ????? ????? ? ? ??????+????? ?????, ?????? ????? ????? ?? ??? ????. ??: ??? ???????? ????????? ???? ??? ?? ? ? ???? ??? ??? ???. ?? ???? ??? ?? ? ? ??? ???? ?? ? ????? ???? ??? ????? ??? ???? ??? ? ???.
关键词： Epiretinal membrane,Retinal layer thickness,Optical coherence tomography
更新于2025-09-04 15:30:14
-
Effects of Surface Termination and Layer Thickness on Electronic Structures of LaNiO <sub/>3</sub> Thin Films
摘要： We investigate the e?ects of surface termination and layer thickness on the electronic structures of LaNiO3 thin ?lms on SrTiO3 substrate using ?rst-principles density-functional theory calculations. The NiO2-terminated ?lm with one unit cell thickness shows a pseudogap at the Fermi level owing to the negative charge transfer energy, whereas the 1.5-unit-cell-thick LaO-terminated ?lm exhibits an insulating gap of 1.0 eV as a result of the large exchange splitting. The metallic state is quickly restored for thicker ?lms with either NiO2 or LaO termination, resembling that in bulk nickelate. Our results indicate the strong dependence of the electronic properties on layer thickness and provide insightful information into the metal–insulator transition in LaNiO3 thin ?lms.
关键词： surface termination,electronic structures,layer thickness,LaNiO3 thin films,metal–insulator transition
更新于2025-09-04 15:30:14