- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
A hybrid nanomaterial with NIR-induced heat and associated hydroxyl radical generation for synergistic tumor therapy
摘要： Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatform based on carbon sphere dotted with cerium oxide and coated by cell membrane (MCSCe) was designed and synthesized with good biocompatibility, homologous targeting ability, and improved photophysical activity. Notably, MCSCe could realize accumulation of hydrogen peroxide (H2O2) in tumor cells and hyperthermia under single laser (808 nm) irradiation, which were simultaneously utilized by itself to produce more toxic hydroxyl radical (·OH). Resultantly, the synergistic therapeutic effect against tumor cells was obtained under near infrared (NIR) laser irradiation.
关键词： cerium oxide,H2O2 self-accumulation,cell membrane,tumor therapy,carbon sphere
更新于2025-11-21 11:01:37
-
Rationally Designed Multifunctional Carbon-Palladium Nanohybrids for Wide Applications: From Electrochemical Catalysis/Nonenzymatic Sensor to Photothermal Tumor Therapy
摘要： Palladium nanomaterials have been widely investigated in many areas due to their high activity of catalysis and surface plasmon resonance (SPR) resulting from their special configuration of outer electron. Herein, the novel nanoparticles, reduced graphene oxide modified with palladium nanoflowers (rGO/PdNFs), were designed and synthesized by seeded growth. Their application potentials in three areas were explored, including electrochemical ethanol catalysis, nonenzymatic glucose sensor and photothermal tumor therapy. The hybrids of PdNFs and rGO increased the conductivity and active sites of PdNFs, and then enhanced the activity of catalysis. Interestingly, through control of morphologies, the absorption of PdNFs in near infrared region was enhanced compared with common palladium nanoparticles, which showed excellent potential in photothermal tumor therapy. These results indicated the stronger activity of catalysis to ethanol of rGO/PdNFs compared with the commercial Pd/C catalyst, superior sensitivity and selectivity of glucose, and effective photothermal antitumor efficacy. Overall, it is demonstrated that the multifunctional rGO/PdNFs nanohybrids could possess more application potentials.
关键词： Nonenzymatic sensor,Photothermal tumor therapy,Reduced graphene oxide,Palladium nanoflowers,Electrochemical catalysis
更新于2025-09-23 15:22:29
-
Ultrasmall MoS2 Nanodots Doped Biodegradable SiO2 Nanoparticles for Clearable FL/CT/MSOT Imaging Guided PTT/PDT Combination Tumor therapy
摘要： Recently, we developed ultrasmall molybdenum disulfide (MoS2) quantum dots for computed tomography (CT) and multispectral optoacoustic tomography (MSOT) image-guided photothermal therapy (PTT). But, due to the rapid body elimination and the limited blood circulation time, the tumor uptake of the dots is low. In our study, this problem was solved via designing an amino modified biodegradable nanomaterial based on MoS2 quantum dots doped disulfide-based SiO2 nanoparticles (denoted MoS2@ss-SiO2) for multimodal application. By integrating the MoS2 quantum dots into clearable SiO2 nanoparticles, this nanoplatform with an appropriate particle size can not only degrade and excrete in a reasonable period induced by the redox-responsive with the glutathione (GSH), but also exhibits a high tumor uptake due to the longer blood circulation time. Moreover, hyaluronic acid (HA) and chlorin e6 (Ce6) were adsorbed on the outer shell for the tumor targeting effect and photodynamic therapy, respectively. So this biodegradable and clearable theranostic nanocomposite applicable in integrated fluorescence(FL)/CT/MSOT imaging guided combined photothermal therapy (PTT) and photodynamic therapy (PDT) is very optimistic in biomedical applications in the future.
关键词： biodegradable,multi-modal imaging,clearable,combination tumor therapy,ultrasmall MoS2 quantum dots
更新于2025-09-23 15:22:29
-
A Graphenea??Based Flexible Device as a Specific Fara??Infrared Emitter for Noninvasive Tumor Therapy
摘要： Noninvasive treatments are emerging as a promising strategy not only due to their non-invasive nature, but also due to their additive effects to traditional radiotherapy and chemotherapy. Herein, specific far-infrared rays generated from single-layer, graphene-based devices are applied to tumors as a novel noninvasive therapeutic strategy. In MDA-MB-231 breast cancer cell xenograft and metastasis models, irradiation generated from this flexible device reduces the rate of tumor growth and the number of metastatic nodules per lung by 42% and 55%, respectively. This result might be induced by the similarity between the emission spectra of the device and the absorption spectra of the living tissue. With its high energy conversion and safety, the graphene-based device can serve as an adjuvant therapeutic instrument for combined tumor treatment.
关键词： far-infrared ray,graphene,noninvasive tumor therapy,resonant absorption
更新于2025-09-19 17:13:59
-
Vapreotide-Mediated Hierarchical Mineralized Au/Ag nanoshells for Photothermal Anti-Tumor Therapy
摘要： A new type of vapreotide-template Ag/Au bimetallic nanoshells (Vap@Ag/AuNSs) were successfully designed and fabricated based on polypeptide-directed mineralization and hierarchical self-assembly mechanisms under mild synthetic conditions. The nanoparticles with polypeptides serving as a core and coating Ag/Au bimetallic nanoshells exhibit diverse advantages such as excellent biocompatibility, tumor targeting and low-cost. The Vap@Ag/AuNSs share excellent dispersibility, uniform size (120 nm) and a positive zeta potential (36.74±4.49 mV), hence they easily accumulate in negatively charged tumor tissue. The results of thermal imaging, temperature variation assay and photothermal conversion efficiency (41.6%) indicated that Vap@Ag/AuNSs have excellent photothermal conversion capability. Based on their photothermal response as well as biocompatibility determined by MTT assay, the prominent anti-tumor effects of Vap@Ag/AuNSs have been verified by fluorescein diacetate staining. Therefore, Vap@Ag/AuNSs are novel and promising candidates for photothermal tumor therapy.
关键词： Vapreotide-templated Au/Ag nanoshells,Biocompatibility,Photothermal therapy,Galvanic replacement,Anti-Tumor Therapy
更新于2025-09-10 09:29:36
-
Near-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo-phototherapy with temperature-responsive drug release
摘要： The aim of this study was to develop a multifunctional theranostic agent based on BSA nanoparticles (NPs), which loaded artemisinin (ART) and co-conjugated with indocyanine green (ICG) and arginine-glycine-aspartic acid (RGD) peptide (RGD-indocyanine green-Bovine Serum Albumin- artemisinin [IBA] NPs). The physicochemical parameters of RGD-IBA NPs were characterized in terms of the particle size, zeta potential, morphology, entrapment efficiency, drug loading, in vitro release behavior, photothermal and photodynamic effect, and in vitro anticancer ability. In vivo fluorescence and thermal imaging as well as antitumor studies were also evaluated. The tumor chemotherapeutic effects of ART and the ability of fluorescence imaging, hyperthermia generation and reactive oxygen species production of ICG and tumor-targeting RGD were integrated to achieve RGD-IBA NPs for imaging-guided tumor-targeted chemotherapy/photothermal/photodynamic therapy (chemo-phototherapy). The RGD-IBA NPs showed enhanced physiological stability and photo-stability compared with free ART and ICG. In addition, they were temperature-responsive; their sizes increased with increasing temperature between 25°C and 55°C, thereby leading to drug release upon the irradiation with near infrared (NIR) laser. In vivo fluorescence images of tumor-bearing mice showed that the RGD-IBA NPs could highly and passively reach the targeted tumor region with maximum accumulation at 24 hours post-intravenous injection. The in vitro and in vivo results demonstrated that the RGD-IBA NPs not only have good biocompatibility, but also are highly efficient tumor synergistic chemo-phototherapeutic agents. Through this study, it was found that RGD-IBA NPs could potentially be a very promising tumor theranostic agent.
关键词： chemo-phototherapy,indocyanine green,imaging-guided tumor therapy,artemisinin,theranostic
更新于2025-09-04 15:30:14