- 标题
- 摘要
- 关键词
- 实验方案
- 产品
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Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells
摘要： Exosomes are a novel and promising drug delivery platform because of their endogenous origin, stability, biocompatibility, and other unique features. As the efficient loading and delivery of long RNA to target cells for therapeutic purposes remains challenging, a new exosome-based RNA delivery system is proposed using a controllable RNA enrichment and releasing protocol. The system employs RNA aptamer–protein interactions and reversible light-inducible protein–protein interaction modules by remolding exosome producer cells. Endogenous microRNA 21 (miR-21) sponges, inhibitors of miR-21, are successfully enriched on the plasma membrane and are sorted into exosomes by the biogenesis of the exosomes. The loading capacity of miR-21 sponges is enhanced by 14-fold in the light-inducible loading system. In addition, targeted delivery of miR-21 to leukemia cells is achieved by modifying exosomes with the cholesterol-conjugated aptamer AS1411, resulting in significant cell apoptosis by blocking the function of miR-21 in leukemia cells. This work provides an exosome-based light-inducible vehicle to efficiently load and deliver long endogenous RNA, which can enable more RNA-based therapeutics for personalized cancer medicine.
关键词： miRNA sponge,leukemia,RNA enrichment,exosomes,reversible light-inducible vehicles,aptamers
更新于2025-09-23 15:23:52
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[IEEE 2018 IEEE PELS Workshop on Emerging Technologies: Wireless Power Transfer (WoW) - Montréal, QC, Canada (2018.6.3-2018.6.7)] 2018 IEEE PELS Workshop on Emerging Technologies: Wireless Power Transfer (Wow) - Modeling and Analysis Methods for the DWPT System Applicated in EVs Charging
摘要： The difficulty of modeling a dynamic wireless power transfer (DWPT) system for Electric Vehicles(EVs) charging is that its mutual inductance changes with the coil offset, so we have to build a dynamic model of the system. In this paper,we propose a modeling method by using equivalent circuit method and state space averaging.Moreover,based on the set of system parameters,comparing the results of the simulation experiment with the result of the model calculation.At last, the performance indexes of the system under the different buck duty cycle are observed. The simulation results of these indexes are also basically consistent with the model calculation results, which further verify the accuracy of the model.At the same time,we found that the selection of duty cycle has a great influence on the performance indexes.
关键词： Dynamic Wireless Power Transfer (DWPT),Equivalent Circuit Method,Electric Vehicles(EVs),State Space Averaging,Dynamic Model
更新于2025-09-23 15:23:52
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Fabrication of large scale PS monolayer colloidal crystal film by using a novel secondary self-assembly method for nanoimprint technique
摘要： In the dynamic wireless power transfering(WPT) process of electric vehicle, the charging current of the battery is affected by some factors, such as the primary coil current and the relative position of the primary and secondary coils. Moreover, due to the travel of the electric vehicle, it is difficult to establish effective feedback between the primary side and secondary side. In this case, the charging method based on the primary side and secondary side independent control is analyzed. In this paper, it shows that the PID controller is set up after modeling the transmitter and the receiver. The effectiveness of this strategy is also verified by simulation on MATLAB.
关键词： WPT,electric vehicles,constant current control,PID
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE International Conference on Imaging Systems and Techniques (IST) - Krakow, Poland (2018.10.16-2018.10.18)] 2018 IEEE International Conference on Imaging Systems and Techniques (IST) - Intelligent Navigation and Control of a Prototype Autonomous Underwater Vehicle for Automated Inspection of Aquaculture net pen cages
摘要： Aquaculture is one of the fastest growing food sectors worldwide providing more than 50% of world fish consumption. Towards sustainable development, aquaculture ought to design and implement technical solutions for the efficient management of farms, thus improving fish performance and decreasing operational costs, human effort and environmental impact. For this, periodic inspection of fish-cages along with early warning systems are required, functionalities that small-sized underwater vehicles can provide. In this paper, an efficient methodology for intelligent navigation of an Autonomous Underwater Vehicle (AUV) architecture is presented, yielding to a useful tool with advanced capabilities in terms of automated manipulation via real-time optical recognition approaches, miniaturization of sensors and processing units, selective monitoring, data recording/transmission operations and proper parameter calculations for further offline-analysis of captured information. The proposed AUV system constitutes an increased Technology Readiness Level version of the preliminary prototype designed earlier by our group, incorporating additional modules and application capabilities, focusing on regular periodic fish-cage net inspection in terms of net holes and fouling. The optical navigation scheme has been tested in laboratory installations under numerous scenarios so as to determine the factors affecting its robustness and efficiency. Results extracted under the validation procedure in operational conditions indicate that the proposed framework can prove a cost-effective, flexible and operative solution for aquaculture industry, enabling the transfer of operations further offshore.
关键词： remote operation,automated navigation,optical recognition,machine vision,net inspection,autonomous underwater vehicles
更新于2025-09-23 15:22:29
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Powertrain control of a solar photovoltaic-battery powered hybrid electric vehicle
摘要： This paper proposes a powertrain controller for a solar photovoltaic battery powered hybrid electric vehicle (HEV). The main objective of the proposed controller is to ensure better battery management, load regulation, and maximum power extraction whenever possible from the photovoltaic panels. The powertrain controller consists of two levels of controllers named lower level controllers and a high-level control algorithm. The lower level controllers are designed to perform individual tasks such as maximum power point tracking, battery charging, and load regulation. The perturb and observe based maximum power point tracking algorithm is used for extracting maximum power from solar photovoltaic panels while the battery charging controller is designed using a PI controller. A high-level control algorithm is then designed to switch between the lower level controllers based on different operating conditions such as high state of charge, low state of charge, maximum battery current, and heavy load by respecting the constraints formulated. The developed algorithm is evaluated using theoretical simulation and experimental studies. The simulation and experimental results are presented to validate the proposed technique.
关键词： maximum power point tracking (MPPT),battery management system,solar photovoltaic,hybrid electric vehicles (HEVs)
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE International Conference on Automation/XXIII Congress of the Chilean Association of Automatic Control (ICA-ACCA) - Concepcion, Chile (2018.10.17-2018.10.19)] 2018 IEEE International Conference on Automation/XXIII Congress of the Chilean Association of Automatic Control (ICA-ACCA) - Comparison of vegetation indices acquired from RGB and Multispectral sensors placed on UAV
摘要： This manuscript presents a comparison of Normalized Difference Vegetation Index (NDVI) obtained with multispectral cameras versus four indices obtained from RGB sensors for the identification of soil and vegetation in images captured with an unmanned aerial vehicle. This comparison was made using the NDVI as ground truth, obtaining 2 classes of data that would be compared later to the other indexes by counting the pixels corresponding to each class. In the case of the RGB indices, the average was defined as the center of the data and as the cut-off point of both classes. The results of this investigation indicated that it is possible to identify the same spatial patterns using RGB indices, where the TGI index shows the best behavior. However, despite the fact that the pixel count showed similar results, the visual inspection of the results indicated that the RGB indices presented errors when identifying the vegetation, especially in the zone of the row. This indicates that to delimit with precision the areas corresponding to vegetation and soil it is necessary to use more complex clustering techniques.
关键词： Image processing,Agricultural engineering,Unmanned aerial vehicles (UAV)
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE International Conference on Automation/XXIII Congress of the Chilean Association of Automatic Control (ICA-ACCA) - Concepcion, Chile (2018.10.17-2018.10.19)] 2018 IEEE International Conference on Automation/XXIII Congress of the Chilean Association of Automatic Control (ICA-ACCA) - Using clustering algorithms to segment UAV-based RGB images
摘要： This article describes the implementation of two segmentation algorithms in combination with the Triangular Greenness Index (TGI) derived from images obtained from an unmanned aerial vehicle (UAV), with the objective of segmenting shadow, soil and vegetation data obtained from a commercial vineyard cv. Cabernet Sauvignon. The importance of this segmentation lies in the recent development in tools that allow remote monitoring of crops but that nevertheless still have unresolved methodological aspects. The precise differentiation of these classes would allow the development of more complex monitoring techniques based on multispectral and thermal sensors. The results of this investigation showed that both k-means and Clustering Large Applications (CLARA) allowed to differentiate three classes in the images corresponding to soil, shade and vegetation. However, CLARA showed a better performance when differentiating the layer corresponding to vegetation.
关键词： Image processing,Unmanned aerial vehicles,Agricultural engineering,Open source software
更新于2025-09-23 15:22:29
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[IEEE 2018 UKSim-AMSS 20th International Conference on Computer Modelling and Simulation (UKSim) - Cambridge, United Kingdom (2018.3.27-2018.3.29)] 2018 UKSim-AMSS 20th International Conference on Computer Modelling and Simulation (UKSim) - Design and Simulation of Solar Grid-Connected Charger for Electric Vehicles
摘要： The paper presents a solar-powered electric vehicle (EV) charging station designed for green energy utilization. The system integrates photovoltaic (PV) panels, DC-DC power converters, and inverters to convert solar energy into usable power for EVs. A simulation model is developed to analyze the charging process, energy efficiency, and grid interaction. Results show that the system can effectively charge multiple EVs with minimal grid dependency, promoting sustainable transportation. The design includes calculations for voltage, current, and power ratings, validated through simulation comparisons.
关键词： Inverters,Simulation,Green design,Electric Vehicles,Charging stations,DC-DC power converters
更新于2025-09-23 15:22:29
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[IEEE 2018 Wave Electronics and its Application in Information and Telecommunication Systems (WECONF) - Saint-Petersburg, Russia (2018.11.26-2018.11.30)] 2018 Wave Electronics and its Application in Information and Telecommunication Systems (WECONF) - Electronic Methods to Protect Unmanned Aerial Vehicles from Seizing Control
摘要： the article deals with the issues of security in the transmission of control information over a wireless communication channel between an unmanned aerial vehicle and the control panel, as well as options for electronic methods of protection against external (unauthorized) interception of control of unmanned aerial vehicles.
关键词： wireless data transfer,remote control,control interception,wireless networks,unmanned aerial vehicles
更新于2025-09-23 15:22:29
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[IEEE 2018 15th European Radar Conference (EuRAD) - Madrid, Spain (2018.9.26-2018.9.28)] 2018 15th European Radar Conference (EuRAD) - A UAV Airborne Passive Digital Radar for Aerial Surveillance
摘要： This paper presents a detailed overview of an experimental passive radar payload developed by ONERA the French Aerospace Lab., which improves the performances of VHF passive radar by using Unmanned Aerial Vehicle (UAV) as support of the receiver. This article highlights the passive radar design which is based on techniques inspired from modern digital receivers combining front-end digitizer and FPGA-based real time data signal processing.
关键词： aerial surveillance,front-end digitizer,passive detection,digital radar,unmanned aerial vehicles
更新于2025-09-23 15:21:21