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Multiphysics Simulation of Biosensors Involving 3D Biological Reaction-Diffusion Phenomena in a Standard Circuit EDA Environment
摘要： The topic of this paper is the development of biological models for 3D reaction–diffusion phenomena that can be used in any circuit electronic design automation environment for the simulation of biosensors. Biological systems that involve such 3D phenomena are described by partial differential equations. Our approach consists in discretizing these equations according to the finite-difference method and converting the resulting ordinary differential equations into an assembly of elementary electronic equivalent circuits that are directly simulated with SPICE. The main interest of this approach is the ability to couple such models with third-party SPICE models of electronic circuits, sensors, and transducers, i.e., models from any physical domain ruled by Kirchhoff laws, allowing modeling and simulation of any multi-physics systems in a conventional circuit design environment, here CADENCE. The tool is validated on simple problems for which analytical solutions are known. Then, the interest of the approach is illustrated on the study of a biosensor.
关键词： reaction-diffusion,Biosensor,virtual prototyping,biochemical reaction,ion-sensitive FET
更新于2025-09-23 15:22:29
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Complex Systems Design & Management (Proceedings of the Ninth International Conference on Complex Systems Design & Management, CSD&M Paris 2018) || A Domain Model-Centric Approach for the Development of Large-Scale Office Lighting Systems
摘要： The high-tech system industry faces many challenges, such as continuously increasing system complexity, scale and customer demands. We address these challenges using a domain model-centric approach. This approach focuses on clear and formal system specifications, connected to a chain of automatic transformations for system analysis, including virtual prototyping, and system synthesis, e.g. code generation. We have applied the approach to the development of large-scale office lighting systems in order to reduce development effort and handle the complexity of system control.
关键词： virtual prototyping,system complexity,code generation,domain model-centric approach,large-scale office lighting systems
更新于2025-09-04 15:30:14