- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
摘要： Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE). These probes showing advantages such as low background interference, superior photostability, acceptable cell toxicity, and potent inhibitory activity, which could be used to image hERG channels at the nanomolar level. These AIE light-up probes hoped to provide guidelines for the design of more advanced AIE sensing and imaging hERG channels to a broad range of applications.
关键词： hERG channel,pharmacophore,fluorophore,cell imaging,AIE light-up probes
更新于2025-11-21 11:24:58
-
N-arylated bisferrocene pyrazole for dual-mode detection of hydrogen peroxide: AIE-active fluorescent “turn on/off” and electrochemical non-enzymatic sensor
摘要： A series of new N?arylated bisferrocene pyrazole (D-π-A-π-D) chromophores have been synthesized by the Chan?Lam cross-coupling (1, 2) and Buchwald–Hartwig amination (3, 4) reactions. The compounds 1-4 were characterized with the aid of analytical and spectroscopic methods. The solvatochromism behaviour of compounds (1, 3) showed positive solvatochromism and later (2, 4) exhibited negative solvatochromism. The compounds 1-4 interestingly showcased high-enhanced fluorescent intensity in their aggregate state while in the solution state they exhibited low fluorescent intensity behaviour. The origin of enhanced emission in the aggregated state is due to a restriction of intramolecular rotation, especially in the ratio of mixture 40:60 (CH3CN/H2O). The aggregation-induced emission(AIE) properties were utilized to detect the H2O2 which show quick response in a linear range of 10-50 μM with a detection limit of 38.8 nM (1) and 15.9 nM (3). Furthermore, the electrochemical reduction of hydrogen peroxide in the same linear range as above showed and a limit of detection (3σ) of 14.4 mM (1) and 11.6 mM (3).
关键词： Dual-mode detection of H2O2,Electrochemical non?enzymatic sensor,AIE-active luminogens
更新于2025-11-14 15:29:11
-
Design, synthesis and structural optimization of two click modified butterfly molecules: Aggregation induced ratiometric fluorescence change and ICT associated hydrogen bonding effect in solvatochromic analysis
摘要： Two click modi?ed butter?y molecules are designed and synthesized having presence and absence of the aggregative moiety to differ between aggregation induced ratiometric emission changes via excimer formation and ICT associated hydrogen bonding effect. These two distinct phenomena can be successfully employed in solvatochromic analysis. This is also supported by the theoretical study through the structural variation of the two butter?y molecules.
关键词： Hydrogen bonding,Butter?y molecules,Ratiometric,AIE,Solvatochromic
更新于2025-09-23 15:22:29
-
Squaraine dyes: interaction with bovine serum albumin to investigate supramolecular adducts with aggregation-induced emission (AIE) properties
摘要： Bovine Serum Albumin (BSA)–squaraine supramolecular adducts with aggregation-induced emission (AIE) properties were prepared and characterized by spectroscopic methods. While squaraine dyes showed very low fluorescence quantum yield in water, a great enhancement in the fluorescence of the aggregated BSA adducts was achieved due to the abnormal aggregation-induced emission properties of squaraines. The adducts formation was studied from a kinetic point of view showing unexpected structure-properties relationships.
关键词： squaraines,supramolecular adducts,Bovine Serum Albumin (BSA),kinetics,Aggregation-induced emission (AIE)
更新于2025-09-23 15:22:29
-
NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging
摘要： Near-infrared (NIR) nanoparticles (NPs) based on fluorescence resonance energy transfer (FRET) were prepared by co-encapsulation of a red aggregation-induced emission (AIE) molecule, 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB), and a commercial NIR fluorescence dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775) with an amphiphilic polymer poly(styrene-co-maleic anhydride) (PSMA). The surface of the NPs, PSMA@TB/NIR775, was modified with poly(ethylene glycol) (PEG) to increase the in vivo biocompatibility of the NPs. The PSMA@TB/NIR775 NPs showed a strong NIR (780 nm) narrow emission and excellent two-photon absorption property. Moreover, the NPs exhibited good monodispersity, stability, and low cytotoxicity. Under the excitation of a 1040 nm femtosecond (fs) laser, the emission peaks at 680 nm of TB and 780 nm of NIR775 excited by FRET were obtained. We utilized PSMA@TB/NIR775 NPs as fluorescent contrast agents for two-photon excited NIR microscopic imaging, and good NIR imaging effect of mouse brain vasculature was obtained with the imaging depth of about 150 μm. The FRET strategy by co-encapsulating AIE molecule and NIR dye will be helpful in preparing more narrow emission NIR probes for deep-tissue biological imaging.
关键词： Two-photon imaging,FRET,NIR emission,AIE,Amphiphilic polymer
更新于2025-09-23 15:22:29
-
Triptycene-scaffolded tetraphenylethylenes with irregular temperature-dependence AIE
摘要： A series of new tetraphenylethylene monomer, dimer and three-dimensional trimer based triptycene-bridged triphenylethenes has been constructed. Their structures were clearly confirmed and the irregular fluorescent behaviors at different temperatures and solvents were investigated. Results showed the new tetraphenylethylenes performed remarkable aggregation-induced emission (AIE) properties and the emission intensities are dependent on temperature and viscosity. Compared with the model tetraphenylethylene without connecting triphenylethylene, the fluorescence quantum yields of the titled triptycene-scaffolded tetraphenylethylenes in aggregation are greater than tetraphenylethylene and increased as the increasing of the triphenylethylene units.
关键词： Tetraphenylethylene,Triptycene,Triphenylethene,AIE
更新于2025-09-23 15:22:29
-
Aggregation Induced Emission Small Molecules for Blue Light-Emitting Electrochemical Cells
摘要： Two blue aggregation induced emission (AIE) luminogens containing phenanthroimidazole and tetraphenylethylene were designed and synthesized. The optical properties, thermal stability, electronic properties, electrochemical properties and electroluminescence of both the derivatives were studied. The phenanthroimidazole derivatives show good thermal stability and AIE properties. The non-doped light-emitting electrochemical cell devices were fabricated using these luminogens as light-emitting materials. The LEC devices show blue color emission centered at 474 nm with good performances.
关键词： Photoluminescence,Electroluminescence,SMs,AIE
更新于2025-09-23 15:22:29
-
Geminal Cross Coupling (GCC) Reaction for AIE Materials
摘要： Tetraphenylethylene (TPE) derivatives are typical aggregation-induced emission (AIE) molecules, which have been widely investigated and applicated. The Rathore’s procedures and McMurry reaction are the two frequently used methods for synthesizing the TPE derivatives. The complex processes and low tolerance of active function groups make the TPE with limited structures and properties in some degree. Very recently, a novel strategy, named geminal cross coupling (GCC) reaction, is developed for designing and synthesizing various topological small molecules and polymers with rich optical properties beyond simple TPE compounds, and becomes a powerful synthesis method to AIE materials. This review overviews the current progresses of AIE molecules and polymers prepared by GCC as well as their applications. We believe that GCC reaction will have a bright future in the development of the next generation of tetraarylethylene (TAE)-kind AIE materials.
关键词： GCC reaction,Conjugated polymer,Tetraarylethylene,AIE,Imaging
更新于2025-09-23 15:22:29
-
AIE based “on-off” fluorescence probe for the detection of Cu2+ ions in aqueous media
摘要： A simple hydrazine carboxamide derivative with intramolecular charge transfer and aggregartion induced emission (AIE) properties have been designed and synthesized. The derivative (Probe 1) shows typical AIE characteristic emission in THF-water mixtures and emits yellowish orange color on reaching the water fraction 98%. The probe molecule show selective sensing response for Cu2+ ions via fluorescence turn-off mechanism in aqueous media over other metal ions. The emission changes towards Cu2+ ions could be clearly observed by the naked eyes under 365 nm UV lamp promote the probe molecule as a promising candidate for practical utilization. Furthermore, from the fluorescence titration data, the detection limit for Cu2+ ions was found to be 0.44 μM.
关键词： AIE,visual sensing,Cu2+ ions
更新于2025-09-23 15:21:01
-
In Vivo Bioimaging of Silver Nanoparticle Dissolution in the Gut Environment of Zooplankton
摘要： Release of silver ions (Ag+) is often regarded as the major cause for silver nanoparticles (AgNPs) toxicity towards aquatic organisms. Nevertheless, differentiating AgNPs and Ag+ in complicated biological matrix and its dissolution remains a bottleneck in our understanding of AgNPs behavior in living organisms. Here, we directly visualized and quantified the time-dependent release of Ag+ from different sized AgNPs in an in vivo model zooplankton (Daphnia magna). A fluorogenic Ag+ sensor was used to selectively detect and localize the released Ag+ in daphnids. We demonstrated that the ingested AgNPs were dissoluted to Ag+, which was heterogeneously distributed in daphnids with much higher concentration in the anterior gut. At dissolution equilibrium, a total of 8.3-9.7% of ingested AgNPs was released as Ag+ for 20 nm and 60 nm AgNPs. By applying a pH sensor, we further showed that the dissolution of AgNPs was partially related to the heterogenous distribution of pH in different gut sections of daphnids. Further, Ag+ was found to across the gills and enter the daphnids, which may be a potential pathway leading to AgNPs toxicity. Our findings provided fundamental knowledge about the transformation of AgNPs and distribution of Ag+ in daphnids.
关键词： guts,Daphnia,AgNPs,AIE,bioimaging,dissolution
更新于2025-09-23 15:21:01