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Multifunctional nanoclusters of NaYF4:Yb3+,Er3+ upconversion nanoparticle and gold nanorod for simultaneous imaging and targeted chemotherapy of bladder cancer
摘要： This paper reports successful synthesis of multifunctional nanoclusters of upconversion nanoparticle (UCNP) and gold nanorod (AuNR) through a PEGylation process. UCNPs emit visible luminescence under near-infrared excitation, producing high-contrast images with no background fluorescence. When coupled with AuNRs, the resulting UCNP-AuNR multifunctional nanoclusters are capable of simultaneous detection and treatment of bladder cancer. These UCNP-AuNR nanoclusters are further functionalized with antibodies to epidermal growth factor receptor (EGFR) to target bladder cancer cells known to overexpress EGFRs. This paper demonstrates, for the first time, efficient targeting of bladder cancer cells with UCNP-AuNR nanoclusters. In addition to high-contrast imaging and consequently high sensitivity detection of bladder cancer cells, highly selective optoporation-assisted chemotherapy was accomplished using a dosage of chemotherapy agent significantly lower than any previous reports, within a clinically relevant incubation time window. These results are highly relevant to the eventual human application in which the nanoclusters and chemotherapy drugs will be directly instilled in bladder via urinary catheter.
关键词： Luminescence upconversion,Surface Plasmon,Bladder Cancer,Gold Nanorod,Optoporation
更新于2025-09-23 15:23:52
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Gold Nanorod-Coated Capillaries for the SERS-Based Detection of Thiram
摘要： Surface enhanced Raman scattering (SERS)-based capillary system is a promising route towards fast, real-time and in-situ detection using a facile sampling process. Here, we demonstrate for the first time resonance-tunable SERS-active capillaries with high sensitivity, reproducibility and stability. The strong signal consistency independent of measurement spots or storage time supports the long-term storage and signal tracking of analytes in practical use. The capillaries were successfully applied to the in-situ detection of pesticide residues, and the sampling process provides operation conveniency compared to conventional methods. These results indicate that our SERS-active capillaries have great potentials in fast in-situ detection for many practical applications.
关键词： surface enhanced Raman scattering,stability,thiram detection,gold nanorod,capillary tube,tunable plasmon resonance
更新于2025-09-23 15:23:52
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Single-Cell Photothermal Neuromodulation for Functional Mapping of Neural Networks
摘要： Photothermal neuromodulation is one of the emerging technologies being developed for neuroscience studies because it can provide minimal-invasive control of neural activity in the deep brain with sub-millimeter precision. However, single cell modulation without genetic modification still remains a challenge, hindering its path to the broad application. Here, we introduce a nanoplasmonic approach to inhibit single neural activity with high temporal resolution. Low intensity of near infrared (NIR) was focused at single cell size on gold nanorod (GNR) integrated microelectrode array platform, generating photothermal effect underneath a target neuron for photothermal stimulation. We found that the photothermal stimulation modulates the spontaneous activity of a target neuron in an inhibitory manner. Single neuron inhibition was fast and highly reliable without thermal damage, and it can induce changes in network firing patterns, potentially suggesting their application for in vivo circuit modulation and functional connectomes.
关键词： photothermal effects,local surface plasmonic resonance,neuromodulation,gold nanorod,neuron
更新于2025-09-23 15:23:52
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GNRs/PPy/m-SiO2 Core/Shell Hybrids as Drug Nanocarriers for Efficient Chemo-Photothermal Therapy
摘要： Combination therapy as a novel strategy with the combination of photothermal therapy and chemotherapy (photothermal-chemotherapy) has aroused the tremendously increasing interest owing to the synergistic therapeutic effect on destroying cancer cells since that the hyperthermia generated from photothermal therapy can promote drug delivery into tumors, which would highly increase therapeutic efficacy as compared to those sole treatments. Herein, we fabricated a novel nanomaterial-based carrier composed of GNRs, polypyrrole (PPy) and mesoporous silica to form GNRs/PPy/m-SiO2 core/shell hybrids. After loading the anticancer drug of doxorubicin (DOX), the photothermal effect and the drug-release behavior of GNRs/PPy@m-SiO2-DOX hybrids were investigated. The in vitro and in vivo near-infrared (NIR) photothermal-chemotherapy were also revealed. The results indicated the NIR-induced photothermal effect was beneficial to promote the release of the drug. In addition, combination therapy demonstrated the enhanced synergistic efficacy and excellent treatment efficacy for cancer therapy.
关键词： drug-controlled release,gold nanorod,mesoporous silica,combination therapy,photothermal,conducting polymer
更新于2025-09-23 15:21:21
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Plasmonic Electronsa??Driven Solara??toa??Hydrocarbon Conversion over Au NR@ZnO Corea??Shell Nanostructures
摘要： This work demonstrates the long-range redox reactivity of gold plasmon-generated hot electrons for solar-driven CO2 conversion. A series of Au NR@ZnO core-shell photocatalysts with a tunable shell thickness are rationally designed to achieve the solar-to-CH4 conversion, where the hot plasmonic electrons-induced photoreduction takes place on the polar oxide moiety. The shell thickness-independent activity implies that the core, gold nanorods, plays a dominant role in the CH4 generation. The ZnO metal oxide semiconductor shell is beneficial to prolong the lifetime of hot electrons, thereby enhancing the photocatalytic efficiency. However, the thickness of ZnO shell is not relevant to the production rate. Both of these two parts are co-excitated by solar light and synergetic enhance the photocatalytic activity.
关键词： gold nanorod,core-shell nanostructure,ZnO,photocatalysis,CO2 photoreduction,plasmon resonance
更新于2025-09-23 15:19:57
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Lattice Distortion in Hollow Multi‐shelled Structures for Efficient Visible Light CO2 Reduction with SnS2/SnO2 Junction
摘要： When nanoparticles interact with cellular or organelle membranes, the coating ligands are known to affect the integrity of the membranes, which regulate cell death and inflammation. However, the molecular mechanisms of this modulation remain unresolved. Here, we use synchrotron X-ray liquid surface scattering and molecular dynamics simulations to study interface structures between phospholipids and gold nanorods (AuNRs) coated by surfactant and polyelectrolyte. These ligands are two types of widely used surface modification with different self-assembled structures and stabilities on the surface of nanoparticles. We reveal distinct mechanisms of the ligand stability in disrupting membrane integrity. We find that the cationic surfactant ligand cetyltrimethylammonium bromide detaches from the AuNRs and inserts into phospholipids, resulting in reduced membrane thickness by compressing the phospholipids the cationic polyelectrolyte ligand poly- ligand. Conversely, (diallyldimethylammonium chloride) is more stable on AuNRs; although it adsorbs onto the membrane, it does not cause much impairment. The distinct coating ligand interactions with phospholipids are further verified by cellular responses including impaired lysosomal membranes and triggered inflammatory effects in macrophages. Together, the quantitative analysis of interface structures elucidates key bio?nano interactions and highlights the importance of surface ligand stability for safety and rational design of nanoparticles.
关键词： phospholipid,X-ray liquid surface scattering,gold nanorod,membrane integrity,ligand stability
更新于2025-09-19 17:13:59
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Poly(3a??hexylthiophene)/Gold Nanorod Composites as Efficient Holea??Transporting Materials for Perovskite Solar Cells
摘要： Poly(3-hexylthiophene)/gold nanorod (P3HT/AuNR) composites were developed and introduced as hole-transporting materials (HTMs) to fabricate mixed-ion perovskite solar cells (PSCs). The power conversion efficiency (PCE) of the optimized devices based on the composite HTM reached up to 16.88%, which was an increase of 26% from that of a pristine P3HT-based device (13.40%). The enhanced performance can be attributed to the increased crystallinity of P3HT induced by the addition of AuNRs in the polymer matrix and the localized surface plasmon resonance (LSPR) effect of AuNRs, which lead to higher carrier mobility and increased light utilization efficiency. This work provides a comprehensive understanding of the effect of plasmonic Au nanorods in PSCs application and a useful method to further improve the performance of PSCs.
关键词： gold nanorod,hole-transporting materials,perovskite solar cells,nanocomposite,P3HT
更新于2025-09-19 17:13:59
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Plasmon-Emitter Hybrid Nanostructures of Gold Nanorod-Quantum Dots with Regulated Energy Transfer as a Universal Nano-Sensor for One-step Biomarker Detection
摘要： Recently, biosensing based on weak coupling in plasmon-emitter hybrid nanostructures exhibits the merits of simplicity and high sensitivity, and attracts increasing attention as an emerging nano-sensor. In this study, we propose an innovative plasmon-regulated fluorescence resonance energy transfer (plasmon-regulated FRET) sensing strategy based on a plasmon-emitter hybrid nanostructure of gold nanorod-quantum dots (Au NR-QDs) by partially modifying QDs onto the surfaces of Au NRs. The Au NR-QDs showed good sensitivity and reversibility against refractive index change. We successfully employed the Au NR-QDs to fabricate nano-sensors for detecting a cancer biomarker of alpha fetoprotein with a limit of detection of 0.30 ng/mL, which displays that the sensitivity of the Au NR-QDs nano-sensor was effectively improved compared with the Au NRs based plasmonic sensing. Additionally, to demonstrate the universality of the plasmon-regulated FRET sensing strategy, another plasmon-emitter hybrid nano-sensor of Au nano-prism-quantum dots (Au NP-QDs) were constructed and applied for detecting a myocardial infarction biomarker of cardiac troponin I. It was first reported that the change of absorption spectra of plasmonic structure in a plasmon-emitter hybrid nanostructure was employed for analytes detection. The plasmon-regulated FRET sensing strategy described herein has potential utility to develop general sensing platforms for chemical and biological analysis.
关键词： localized surface plasmon resonance,quantum dot,gold nanorod,biomarker,fluorescence resonance energy transfer,plasmonic-emitter hybrid nanostructure
更新于2025-09-16 10:30:52
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Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity
摘要： Plasmonic photothermal therapy (PPTT) has been used as an alternative to chemotherapy for the elimination of resistant microorganisms; however, its in situ evaluation has not been well studied. In the present study, we assessed the antimicrobial activity of a chitosan-based hydrogel embedded with gold nanorods (Ch/AuNRs) using a low power infrared diode laser. The antibacterial activity was measured in both Gram-positive and –negative strains, including clinical isolates of multidrug-resistant pathogens. The cytotoxic effect, cellular proliferation, and the expression of the pro-inflammatory (IL-6 and TNF-α) and anti-inflammatory (IL-10) cytokines were quantified in a murine model of macrophages. Results showed a potent antimicrobial activity of the Ch/AuNRs with MICs ≤4 μg/mL, very low cytotoxicity with cell viability above 80%, and the macrophage proliferation was not affected for a period of 48 h. These results suggest that our Ch/AuNR-embedded hydrogel could be an option to locally control chronic nosocomial infections using PPTT.
关键词： inflammation,multidrug resistant,antifungal,photothermal therapy,gold nanorod,cytotoxicity,chitosan,antibacterial
更新于2025-09-16 10:30:52
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DNA Enabled Chiral Gold Nanoparticle - Chromophore Hybrid Structure with Resonant Plasmon – Exciton Coupling Gives Unusual and Strong Circular Dichroism
摘要： Circular dichroism (CD) from hybrid complexes of plasmonic nanostructures and chiral molecules has recently attracted significant interest. However, the hierarchical chiral self-assembly of molecules on surfaces of metal nanostructures has remained challenging. As a result, a deep understanding of plasmon-exciton coupling between surface plasmons and chiral collective molecular excitations has not been achieved. In particular, the critical impact of resonant plasmon-exciton coupling within the hybrid is unclear. Here, we employed DNA-templated strategies to control the chiral self-assembly of achiral chromophores with rationally tuned exciton transitions on gold nanosphere (AuNP) or gold nanorod (AuNR) surfaces. Unlike many previous chiral plasmonic hybrids utilizing chiral biomolecules with CD signals in the UV range, we designed structure with the chiral excitonic resonances at visible wavelengths. The constructed hybrid complexes displayed strong chiroptical activity that depends on the spectral overlap between the chiral collective molecular excitations and the plasmon resonances. We find that when spectral overlap is optimized, the molecular CD signal originating from the chiral self-assemblies of chromophores was strongly enhanced (maximum enhancement of nearly an order of magnitude) and a plasmonic CD signal was induced. Surprisingly, the sign of the molecular CD was reversed despite different self-assembly mechanisms of the Au nanoparticle-chromophore hybrids. Our results provide new insight into plasmonic CD enhancements and will inspire further studies on chiral light-matter interactions in strongly coupled plasmonic-excitonic systems.
关键词： DNA-templated strategies,gold nanorod,chiral molecules,chiroptical activity,gold nanosphere,Circular dichroism,plasmonic nanostructures
更新于2025-09-12 10:27:22