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An AND logic gate-based fluorescence probe for the detection of homovanillic acid, an indicator of the tumor
摘要： Homovanillic acid (HVA) is one of the major metabolites of catecholamine in human. An elevated level of HVA in urine and blood has been associated with many diseases, including catecholamine-secreting tumors. Consequently, detection of the biomarker HVA in urine is an effective strategy to detect cancer precursors and early stage cancers. In this study, a fluorescence probe is designed and fabricated by integrating lanthanide ions with metal-organic frameworks (MOFs). The fluorescence probe shows distinguished response toward HVA and exhibits ratiometric detection of HVA, rendering it an excellent candidate for sensing devices. Thus, we have designed logic gate operation integrating the probe with logical operations for the intelligent sensing of HVA. Furthermore, this type of luminesce based sensors integrated with logic gate augur for the further application in real-time early diagnosis of tumors in the future.
关键词： Rare earth,Homovanillic acid,Fluorescent probe,Logic gate,Ratiometric sensing,Metal-organic frameworks
更新于2025-11-19 16:56:35
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A Label-Free Fluorescent DNA Machine for Sensitive Cyclic Amplification Detection of ATP
摘要： In this study, a target recycled ampli?cation, background signal suppression, label-free ?uorescent, enzyme-free deoxyribonucleic acid (DNA) machine was developed for the detection of adenosine triphosphate (ATP) in human urine. ATP and DNA fuel strands (FS) were found to trigger the operation of the DNA machine and lead to the cyclic multiplexing of ATP and the release of single stranded (SS) DNA. Double-stranded DNA (dsDNA) was formed on graphene oxide (GO) from the combination of SS DNA and complementary strands (CS(cid:48)). These double strands then detached from the surface of the GO and in the process interacted with PicoGreen dye resulting in amplifying ?uorescence intensity. The results revealed that the detection range of the DNA machine is from 100 to 600 nM (R2 = 0.99108) with a limit of detection (LOD) of 127.9 pM. A DNA machine circuit and AND-NOT-AND-OR logic gates were successfully constructed, and the strategy was used to detect ATP in human urine. With the advantage of target recycling ampli?cation and GO suppressing background signal without ?uorescent label and enzyme, this developed strategy has great potential for sensitive detection of different proteins and small molecules.
关键词： cyclic ampli?cation,ATP detection,DNA machine,label-free ?uorescence,graphene oxide,logic gate
更新于2025-11-19 16:46:39
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Fluorescein derived Schiff base as fluorimetric zinc (II) sensor via ‘turn on’ response and its application in live cell imaging
摘要： A novel Schiff base L composed of fluorescein hydrazine and a phenol functionalized moiety has been designed and prepared via cost-effective condensation reaction, which is utilized for selective sensing of Zn2+ over other environmental and biological relevant metal ions in aqueous alcoholic solution under physiological pH range. The binding of Zn2+ to the receptor L is found to causes ~23 fold fluorescence enhancement of L. The 1:1 binding mode of the metal complex is established by combined UV–Vis, fluorescence, and HRMS (high-resolution mass spectroscopy) spectroscopic methods. The binding constant (Ka) for complexation and the limit of detection (LOD) of Zn2+ is calculated to be 2.86×104 M-1 and 1.59 μM, respectively. Further photophysical investigations including steady-state, time-resolved fluorescence analysis and spectral investigations including NMR (nuclear magnetic resonance), IR (infrared spectroscopy) suggest introduction of CHEF (chelation enhance fluorescence) with the suppression of C=N isomerization and PET (photo-induced electron transfer) mechanism for the strong fluorescent response towards Zn2+. Finally, the sensor L is successfully employed to monitor a real-time detection of Zn2+ by means of TLC (thin layer chromatography) based paper strip. The L is used in the cell imaging study using African green monkey kidney cells (Vero cells) for the determination of exogenous Zn2+ by Immunofluorescence Assay (IFA) process.
关键词： Schiff base,molecular logic gate,cell imaging,Zn sensor,PL and TCSPC,UV-Vis
更新于2025-09-23 15:23:52
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Nanoscale Fluorescent Metal?Organic Framework Composites as a Logic Platform for Potential Diagnosis of Asthma
摘要： Asthma is a common chronic disorder, and the decreased hydrogen sulfide (H2S) production in the lung has been considered as an early detection biomarker for asthma. However, the detection of H2S in biological systems remains a challenge; because it requires the designed sensors to have the following features: nanoscale size, good biocompatibility, real-time detection, high selectivity/sensitivity, and good water stability. Here, we propose the potential of using nanoscale fluorescent metal?organic framework (MOF) composites Eu3+/Ag+@UiO-66-(COOH)2 (hereafter denoted as EAUC) as a logic platform for tentative diagnosis of asthma by detecting the biomarker H2S. This INHIBIT logic gate based on Eu3+@UiO-66-(COOH)2 (EUC) can be produced by choosing Ag+ and H2S as inputs and by monitoring the fluorescent signal (I615) as an output. Our fluorescent studies indicate that the EAUC exhibits excellent selectivity, extreme sensitivity (limit of detection: 23.53 μM), and real-time in situ detection of H2S. Further, MTT analysis in PC12 cells shows that the EAUC possesses low cytotoxicity and favourable biocompatibility that are suitable for the detection of biomarker H2S in vivo, as demonstrated by the successful detection of spiked H2S in the diluted serum samples. This work represents the possibility of using MOF-based logic platform for tentative diagnosis of asthma in clinical medicine.
关键词： metal?organic frameworks,logic gate,asthma,chemical sensing,hydrogen sulfide
更新于2025-09-23 15:22:29
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Designing low power and high contrast ratio all-optical NOT logic gate for using in optical integrated circuits
摘要： In this paper, a new design of all-optical NOT logic gate is proposed. In this structure, a photonic crystal nano-resonator and three waveguides are used. The nano-resonator is formed by removing two dielectric rods. The contrast ratio for the proposed NOT logic gate is 20.75?dB. The maximum response time and the rate of sending information equal to 0.466?ps and 2.145?Tbit/s, respectively. In addition, very low power consumption, small size, and simple design are the main features of this logic gate. These features allow the designed structure to be used in all-optical switches. To accomplish this, two types of logic gates placement alongside each other in the optical integrated circuits are proposed and investigated. In both types, the logic gates are tested for single use and simultaneous use, and the accuracy of the performance and effect of each on the other is measured. The results clearly show that the two logic gates, along with each other, have acceptable perfor- mance and can easily be used in the optical integrated circuit.
关键词： Nano-resonator,Optical integrated circuit,All-optical NOT logic gate,Response time,Photonic crystal
更新于2025-09-23 15:21:01
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Implementations of more general solid-state (SWAP)${}^{1/m}$ and controlled-(swap)${}^{1/m}$ gates
摘要： Universal quantum gates are the core elements in quantum information processing. We design two schemes to realize more general (SWAP)1/m and controlled-(swap)1/m gates (for integer m 1? ) by directing ?ying single photons to solid-state quantum dots. The parameter m is easily controlled by adjusting two quarter-wave plates and one half-wave plate. Additional computational qubits are not required to construct the two gates. Evaluations of the gates indicate that our proposals are feasible with current experimental technology.
关键词： quantum computation,quantum logic gate,(SWAP)1/m,quantum dot,controlled-(swap)1/m
更新于2025-09-23 15:19:57
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A novel 1,8-naphthalimide as highly selective naked-eye and ratiometric fluorescent sensor for detection of Hg2+ ions
摘要： A novel colorimetric and ratiometric fluorescent chemosensor, 2-(2-mercaptophenyl)-1H-benzo[de]isoquinoline-1,3-(2H)-dione (L3) is reported for Hg2+ ions. The selective binding of Hg2+ to L3 afforded new absorbance and fluorescence peaks at 438 nm and 480 nm, in addition to the existing bands of L3 at 332 nm and 376 nm. It also showed apparent colour change from colourless to yellowish green and weak fluorescent to bright yellowish green strong fluorescent due to selective binding of Hg2+ ion. The sensor forms a 1:1 stoichiometry with high binding constants (3.89 × 10^4 mol^-1 L) and limit of detection 1.74 × 10^-8 M with high selectivity and sensitivity towards Hg2+ in the presence of other interfering metal ions. More importantly, it has good practicability in environmental water sample. The outcome of photo-physical experiment has also been in good accordance with the time-resolved fluorescence life decays and the density functional theory (DFT) estimations. Moreover, the L3-Hg2+ solution displayed high colorimetric and fluorimetric reversibility via the addition of KI. This reversibility in fluorescence showed potential applicability of chemosensor L3 as 'on–off–on' naked eye sensor.
关键词： Molecular logic gate,Red-shift,DFT,Off–on–off Hg2+ chemosensor,Naked eye detection,Ratiometric fluorescence
更新于2025-09-19 17:15:36
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Frequency-tunable logic gates in graphene nano-waveguides
摘要： In this study, simple basic plasmonic logic gates of XOR, OR, and NOT based on graphene nano-ribbon resonators coupled to properly designed arrangements of nano-waveguides, as input and output logic ports, are demonstrated. The operation of the structures as frequency selective components is based on the propagation of edge modes in nano-waveguides and coupling to nano-ribbon resonators located in appropriate locations. The gates performance is investigated through analytic approaches and verified numerically using the finite difference time domain method. Typical extinction ratio of about 8 dB between ON and OFF logic states has been attained. According to the fantastic feature of voltage-dependent chemical potential of graphene conductivity, the characteristics of the structures can be actively manipulated. These sub-wavelength plasmonic components can be employed extensively in terahertz demanded applications.
关键词： Nano-ribbon resonator,Nano-waveguide,Logic gate,Plasmonic component,Graphene-based component,Terahertz spectra
更新于2025-09-19 17:13:59
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Controlled Logic Gate Based on a Four-Node Linear Hybrid Cluster State
摘要： In the case of a large amount of computation, a situation may arise when the intermediate results of calculations need to be stored for a given time. In this work, we show how to create a hybrid atomic-field cluster state and create a controlled gate in such a way that the results of calculations are recorded under long-lived degrees of freedom of an atomic ensemble and can be stored for a long time.
关键词： cluster quantum state,controlled logic gate,one-way computing,quantum memory
更新于2025-09-16 10:30:52
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A New Optical Information Processing Device Design for Internet of Brain Things Application
摘要： With the development and application of Internet of things, new requirements for optical communication technology are put forward, and this text proposed a new optical information processing device design logic-oriented-based for Internet of brain things application. Three micro rings were coupled with three different shapes of optical waveguide components, their wavelengths were varied with the change of the applied voltages (logical input) so as to control the propagation direction of the input optical signal and the final output forms of lighting or darkness representing different logic level values as the result of the logical operations. The working wavelength of the device was determined as 1.5146μm through static simulations with Matlab tools, and it was proved that the functions of flexible optical switch logic operations "and/not", "or/nor" and "xor/xnor" can be realized in the dynamic simulations, the results indicated that the device with low-power consumption, high-bandwidth, flexible structure and multiple logical operation functions has been accomplished and can be used as components of VLSI designs in future. This work also give a useful reference to many Internet of brain things applied field.
关键词： Electro-optical logic gate,Micro ring resonator,Logical operation,Internet of brain things
更新于2025-09-09 09:28:46