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Development and preliminary results of phase contrast imaging diagnostic on HL-2A
摘要： Phase Contrast Imaging (PCI) diagnostic has been developed on HL-2 A tokamak. The chord integral density fluctuations of plasma can be obtained by measuring the phase shift of CO2 laser which has a wavelength of 10.6 μm after passing through plasma. The 32-channel detector array enables PCI to diagnose density fluctuations with wavenumbers ranging from 2 cm?1 to 15 cm?1. The temporal resolution of PCI is better than 2 μs which makes it suitable for broadband turbulence research. Calibration by the sound source confirms that PCI is able to discriminate a wide range of wavenumbers. The plasma density fluctuations measured by PCI on HL-2 A is presented for the first time. Comparison of MHD instability investigations with magnetic probe data shows the reliability of this PCI diagnostic.
关键词： Phase shift,Plasma density fluctuations,PCI
更新于2025-09-23 15:22:29
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Direct and Label-Free Detection of MicroRNA Cancer Biomarkers Using SERS-Based Plasmonic Coupling Interference (PCI) Nanoprobes
摘要： MicroRNAs (miRNAs), small non-coding endogenous RNA molecules, are emerging as promising biomarkers for early detection of various diseases and cancers. Practical screening tools and strategies to detect these small molecules are urgently needed in order to facilitate the translation of miRNA biomarkers into clinical practice. In this study, a label-free biosensing technique based on surface-enhanced Raman scattering (SERS), referred to as “plasmonic coupling interference (PCI)”, was applied for the multiplex detection of miRNA biomarkers. The sensing mechanism of the PCI technique relies on the formation of a nanonetwork consisting of nanoparticles with Raman labels located between adjacent nanoparticles that are interconnected by DNA duplexes. Due to the plasmonic coupling effect of adjacent nanoparticles in the nanonetwork, the Raman labels exhibit intense SERS signals. Such effect can be modulated by the addition of miRNA targets of interest that act as inhibitors to interfere with the formation of this nanonetwork, resulting in a diminished SERS signal. In this study, the PCI technique is theoretically analyzed and the multiplex capability for detection of multiple miRNA cancer biomarkers is demonstrated, establishing the great potential of PCI nanoprobes as a useful diagnostic tool for medical applications.
关键词： SERS,PCI,miRNAs,cancer biomarkers,MicroRNAs,plasmonic coupling interference,multiplex detection
更新于2025-09-12 10:27:22