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Application of Periodical Nanostructures in Thin Metal Film for Near Infrared Multispectral Filters
摘要： Surface plasmonic nanostructures with cross-shaped-hole array in metal thin films are studied for multispectral filters, which cover visible to near-infrared wavelengths. Surface plasmons are induced from incident wave by the periodic arrays of nanostructures of the metal thin film, and then localized surface plasmon polaritons oscillate in the cavity, which is formed by two surfaces of metals through near-field excitation. The transmission spectra of light through these nanostructures are investigated with the finite-difference time-domain method; our simulations show that the features of the hole, and the periods of the array along with other parameters are critical to the optical spectral performance. The optical characterizations of our fabrications of these nanostructures milled by focused ion beam demonstrated very similar results of transmission spectra of simulation results. The simulations demonstrate he optical performance of the metal nanostructures, it is possible to obtain desired multispectral filters by programming parameters of those plasmonic nanostructures.
关键词： Nanostructures,Multispectral filters,Metallic plasmonic nanostructures
更新于2025-09-23 15:21:01
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Sensitive and Direct DNA Mutation Detection by Surface-enhanced Raman Spectroscopy using Rational Designed and Tunable Plasmonic Nanostructures
摘要： Efficient DNA mutation-detection methods are required for diagnosis, personalized therapy development, and prognosis assessment for diseases such as cancer. To address this issue, we proposed a straightforward approach by combining active plasmonic nanostructures, surface enhanced Raman spectroscopy (SERS), and polymerase chain reaction (PCR), with a statistical tool to identify and classify BRAF wild type (WT) and V600E mutant genes. The nanostructures provide enhanced sensitivity, while PCR offers the high specificity towards target DNA. A series of positively charged plasmonic nanostructures including gold/silver nanospheres, nanoshells, nanoflowers and nanostars, were synthesized with a one-pot strategy and characterized. By changing the shape of nanostructures, we are able to vary the surface plasmon resonance from 551 nm to 693 nm. The gold/silver nanostar showed the highest SERS activity, which was employed for DNA mutation detection. We reproducibly analyzed as few as 100 copies of target DNA sequences using gold/silver nanostars, thus demonstrating the high sensitivity of the direct SERS detection. By means of statistical analysis (principal component analysis-linear discriminant analysis, PCA-LDA), this method was successfully applied to differentiate the WT and V600E mutant both from whole genome DNA (gDNA) lysed from cell line and from cell-free DNA (cfDNA) collected from cell culture media. We further proved that this assay is capable of specifically amplifying and accurately classifying a real plasma sample. Thus, this direct SERS strategy combined with the active plasmonic nanostructures has the potential for wide applications as an alternative tool for sensitively monitoring and evaluating clinical important nucleotide biomarkers.
关键词： PCR,statistical analysis,plasmonic nanostructures,surface-enhanced Raman spectroscopy,DNA mutation detection
更新于2025-09-23 15:21:01
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Topology Optimization-Based Inverse Design of Plasmonic Nanodimer with Maximum Near-Field Enhancement
摘要： The near-field enhancement factor is one of the most significant parameters to evaluate the performance of plasmonic nanostructures. Numerous efforts have been made to maximize the enhancement factor through optimizing the size, shape, and spatial arrangement of metallic nanostructures with simple geometries, such as disk, triangle, and rod. This work implements topology optimization to inversely design a metallic nanoparticle dimer with the goal of optimizing the near-field enhancement factor in its sub-10 nm gap. By optimizing the material layout within a given design space, the topology optimization algorithm results in a plasmonic nanodimer of two heart-shaped particles having both convex and concave features. Full-wave electromagnetic analysis reveals that the largest near-field enhancement in the heart-shaped nanoparticle dimer is originated from the greatest concentration of surface charges at the nano-heart apex. Inversely designed heart-, bowtie-, and disk-shaped nanodimers are fabricated by using focused helium ion beam milling with a “sketch and peel” strategy, and their near-field enhancement performances are characterized with nonlinear optical spectroscopies at the single-particle level. Indeed, the heart-shaped nanodimer exhibits much stronger signal intensities than the other two structures. The present work corroborates the validity and effectiveness of topology optimization-based inverse design in achieving desired plasmonic functionalities.
关键词： topology optimization,near-field enhancement,plasmonic nanostructures,inverse design,nonlinear optics
更新于2025-09-23 15:21:01
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Dynamic actuation of DNA-assembled plasmonic nanostructures in microfluidic cell-sized compartments
摘要： Molecular motor proteins form the basis of cellular dynamics. Recently, notable efforts have led to the creation of their DNA-based mimics, which can carry out complex nanoscale motion. However, such functional analogues have not yet been integrated or operated inside synthetic cells towards the goal of realizing artificial biological systems entirely from the bottom-up. In this Letter, we encapsulate and actuate DNA-assembled dynamic nanostructures inside cell-sized microfluidic compartments. These encapsulated DNA nanostructures not only exhibit structural reconfigurability owing to their pH-sensitive molecular switches upon external stimuli, but also possess optical feedback enabled by the integrated plasmonic probes. In particular, we demonstrate the power of microfluidic compartmentalization for achieving on-chip plasmonic enantiomer separation and substrate filtration. Our work exemplifies that the two unique tools, droplet-based microfluidics and DNA technology, offering high precision on the microscale and nanoscale, respectively, can be brought together to greatly enrich the complexity and diversity of functional synthetic systems.
关键词： plasmonic enantiomer selection,droplet-based microfluidics,DNA origami,plasmonic nanostructures,pH switch
更新于2025-09-23 15:19:57
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Enhancement of the second harmonic signal of nonlinear crystals by self-assembled gold nanoparticles
摘要： In second harmonic generation (SHG), the energy of two incoming photons, e.g., from a femtosecond laser, can be combined in one outgoing photon of twice the energy, e.g., by means of a nonlinear crystal. The SHG efficiency, however, is limited. In this work, the harvested signal is maximized by composing a hybrid system consisting of a nonlinear crystal with a dense coverage of plasmonic nanostructures separated by narrow gaps. The method of self-assembled diblock-copolymer-based micellar lithography with subsequent electroless deposition is employed to cover the whole surface of a lithium niobate (LiNbO3) crystal. The interaction of plasmonic nanostructures with light leads to a strong electric near-field in the adjacent crystal. This near-field is harnessed to enhance the near-surface SHG signal from the nonlinear crystal. At the plasmon resonance of the gold nanoparticles, a pronounced enhancement of about 60-fold SHG is observed compared to the bare crystal within the confocal volume of a laser spot.
关键词： gold nanoparticles,nonlinear crystal,second harmonic generation,lithium niobate,plasmonic nanostructures,electroless deposition,self-assembled diblock-copolymer-based micellar lithography,LiNbO3,SHG
更新于2025-09-23 15:19:57
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Multiple embedded eigenstates in nonlocal plasmonic nanostructures
摘要： Trapping light in open cavities is a long sought “holy grail” of nanophotonics. Plasmonic materials may offer a unique opportunity in this context, as they may fully suppress the radiation loss and enable the observation of spatially localized light states with an infinite lifetime in an open system. Here, we investigate how the spatial dispersion effects, e.g., caused by the electron-electron interactions in a metal, affect the trapped eigenstates. Heuristically, one may expect that the repulsive-type electron-electron interactions should act against light localization, and thereby that they should have a negative impact on the formation of the embedded eigenstates. Surprisingly, here we find that the nonlocality of the material response creates new degrees of freedom and relaxes the requirements for the observation of trapped light. In particular, a zero-permittivity condition is no longer mandatory and the same resonator shell can potentially suppress the radiation loss at multiple frequencies.
关键词： spatial dispersion,nonlocal plasmonic nanostructures,light trapping,embedded eigenstates
更新于2025-09-19 17:13:59
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X-shaped chiral plasmonic nanostructured metasurfaces: A numerical study
摘要： In this paper, the author reports a numerical investigation of spectroscopic circular dichroism (CD) properties, near-field enhancement, and optical chirality near a chiral plasmonic nanostructured metasurface. The individual constituents of the metasurface consist of periodic X -shaped Au nanostructures on a glass substrate. The nanostructure is made of two overlapping nanorods, including one vertical nanorod and one tilted nanorod. Strong CD of the metasurface was observed and tunable upon rotation of the individual nanorods due to geometrical symmetry breaking. Near-field enhancement of up to 5 times and a large local optical chirality were found at a plane 20 nm above the X -shaped nanostructure. Electromagnetic modeling analysis provides valuable guidelines for designing alternative two-dimensional chiral metamaterials that have potential applications for enhanced molecule and chiral plasmon interaction.
关键词： Metasurfaces,Symmetry breaking,Chiral plasmonic nanostructures,Circular dichroism
更新于2025-09-19 17:13:59
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Incorporating Aluminum Plasmonic Nanohemisphere Arrays into Organic Ultraviolet Photodetectors for Improved Photoresponse
摘要： Aluminum nanostructures, which support surface plasmon resonances in the UV spectral range, were incorporated into conventional organic UV photodetectors with a structure of indium tin oxide (ITO)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)/poly(9,9-dioctyl?uorene-alt-bithiophene) (F8T2):[6,6]-phenyl-C71-butyric acid methyl ester (PC71BM)/LiF/Al. Nanohemisphere arrays (NHSAs) were imprinted into the top surface of the soft organic active layer, thus transferring the pattern to the subsequently thermally deposited layers of LiF and Al. NHSA-top devices and ?at-top control devices were investigated by 3-dimensional ?nite-di?erence time-domain (3D-FDTD) electromagnetic simulations. Improved UV active layer absorbance and enhanced electric ?elds in the nanohemispheric region at the top of the active layer were shown for devices with the NHSA-top. The impact of the NHSA-top was found to be more signi?cant for devices with thin active layers and to gradually decrease with increasing active layer thickness. Fabricated NHSA-top devices with thin active layers exhibited improved photoresponse in terms of external quantum e?ciency, speci?c detectivity and on?o? response speed compared to ?at-top devices under 330 nm illumination and 0 to ?1 V bias. The method developed in this work provides a versatile and e?ective way to incorporate plasmonic nanostructures into optoelectronic devices to enhance device performance.
关键词： enhanced photoresponse,aluminum plasmonic nanostructures,organic photodetectors,nanoimprinting,ultraviolet photodetectors
更新于2025-09-19 17:13:59
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Mesoporous polydopamine with built-in plasmonic core: Traceable and NIR triggered delivery of functional proteins
摘要： Functional proteins are essential for the regulation of cellular behaviors and have found growing therapeutic uses. However, low bioavailability of active proteins to their intracellular targets has been a long-standing challenge to achieve their full potential for cell reprogramming and disease treatment. Here we report mesoporous polydopamine (mPDA) with a built-in plasmonic nanoparticle core as a multifunctional protein delivery system. The mPDA with a unique combination of large surface area, metal-chelating property, and broad-spectrum photothermal transduction allows efficient loading and near-infrared light-triggered release of functional proteins, while the plasmonic core serves as a photostable tracer and fluorescence quencher, collectively leading to real-time monitoring and active cytosolic release of model proteins. In particular, controlled delivery of cytotoxic ribonuclease A has shown excellent performance in in-vivo cancer therapy. The possibility of coating mPDA on a broad range of functional cores, thanks to its universal adhesion, provides opportunities for developing tailored delivery carriers of biologics to overcome intrinsic biological barriers.
关键词： cancer therapy,photothermal-responsive,traceable protein delivery,plasmonic nanostructures,mesoporous polydopamine
更新于2025-09-19 17:13:59
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Novel Nanoplasmonic Structure based Integrated Microfluidic Biosensors for Label-Free in Situ Immune Functional Analysis
摘要： The study of immune functional responses is essential to understanding the central role of the immune system in providing immunological host defense and its intercommunication with other systems. The recent development of integrated microfluidic cytokine biosensors has established a new paradigm to identify, isolate, and study immune cell subtypes, cell functions, and intercellular communications that constitute those responses. In this minireview, we highlight the most recent progress in label-free cytokine detection based on localized surface plasmon resonance optical sensing. We present the applications of newly identified plasmonic nanostructures and the integration with advanced microfluidic devices for novel lab-on-a-chip biosensing systems and discuss the associated challenges and future perspective of such integrative sensing technologies for next-generation immune functional analysis.
关键词： immune functional responses,localized surface plasmon resonance,microfluidic cytokine biosensors,plasmonic nanostructures,lab-on-a-chip biosensing systems
更新于2025-09-19 17:13:59