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- 实验方案
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Improving Photovoltaic and Enzymatic-Sensing Performance by Coupling Core-Shell Au Nanorod@TiO2 Heterostructure with Bioinspired L-DOPA Polymer
摘要： The photoelectrochemistry (PEC) performance of TiO2 is somewhat limited by its wide band gap and low quantum efficiency, and the innovation of its composite materials provides a promising solution for an improved performance. Herein, a composite of an Au nanorod@TiO2 core-shell nanostructure (AuNR@TiO2) and a melanin-like L-DOPA polymer (PD) is designed and prepared, where the outer-layer PD tethered by the TiO2-hydroxyl complexation and the AuNR core can intensify the long-wavelength light harvesting, and the AuNR@TiO2 core-shell structure can strengthen the hot-electron transfer to TiO2. The photocurrent of the PD/AuNR@TiO2 is 8.4-fold improved versus that of commercial TiO2, and the maximum incident photon-to-electron conversion efficiency reaches 65% in the UV-visible-near-infrared region. In addition, the novel PD/AuNR@TiO2 photocatalyst possesses the advantages of good biocompatibility and stability, which can act as a versatile PEC biosensing platform for providing biocompatible environment and improving detection sensitivity. Herein, a PEC enzymatic biosensor of glucose is developed on the basis of the immobilization of dual enzyme (glucose oxidase (GOx) and horseradish peroxidase (HRP)) in PD and the signalling strategy of biocatalytic precipitation. In phosphate buffer containing glucose and 4-chloro-1-naphthol, the HRP-catalyzed oxidation of 4-chloro-1-naphthol by GOx-generated H2O2 can form a precipitate on the electrode, by which the decrement of photocurrent intensity is proportional to the common logarithm of glucose concentration. The linear detection range is from 0.05 μM to 10.0 mM glucose, with a limit of detection of 0.01 μM (S/N=3). Glucose in some human serum samples is analyzed with satisfactory results.
关键词： Au nanorod@TiO2 core-shell heterostructure,biocatalytic precipitation,bioinspired L-DOPA polymer,photoelectrochemistry,enzymatic sensing of glucose
更新于2025-11-14 17:04:02
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Construction of Self-Healing Internal Electric Field for Sustainably Enhanced Photocatalysis
摘要： The construction of internal electric field is generally considered an effective strategy to enhance photocatalytic performance due to its significant role in charge separation. However, static internal electric field is prone to be saturated either by inner or outer shield effect, and thus its effect on the improvement of photocatalysis can easily vanish. Here, the self-healing internal electric field is proposed and successfully endowed to a designed helical structural composite microfiber polyvinylidene fluoride/g-C3N4 (PVDF/g-C3N4) based on the bioinspired simple harmonic vibration. Importantly, the saturation and recovery of internal electric field are characterized by transient photovoltage and photoluminescence. The results indicate that the internal electric field could be saturated within about 10 min and refreshed with the assistance of rebuilt piezoelectric potential. The lifetime of photogenerated carriers is about 10?4 s and the number of effective carriers is greatly increased in the presence of self-healing internal electric field. The results provide direct experimental evidence on the role of self-healing internal electric field in charge transfer behavior. This work represents a new design strategy of photocatalysts, and it may open up new horizons for solving energy shortage and environmental issues.
关键词： charge separation,photocatalysis,microfluidics,bioinspired,self-healing
更新于2025-09-23 15:23:52
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Light Control with Liquid Crystalline Elastomers
摘要： The facile synthesis of well-aligned, main-chain liquid crystalline elastomers that retain the cholesteric phase (CLCEs) is reported. The selective reflection inherent to this phase is thermally tuned more than 200 nm in these solid films, across the visible spectrum. The optical response is directly correlated to thermomechanical expansion of the CLCE film thickness. The bandwidth of the selective reflection of the CLCEs is increased to more than 200 nm by the incorporation of photosensitive chiral dopants that introduce heterogeneity in the pitch distribution. The mirror-like reflection of this CLCE film is also thermochromic, shifting from the visible to infrared. Reminiscent of cephalopods, when combined with the mechanical deformation of voxelated nematic liquid crystal elastomer, the thermochromic response of the CLCE produces solid-state elements with concurrent variation of specular and diffuse reflectance. These results demonstrate distinctive potential opportunities for liquid crystal elastomers to control light enabling new application in textiles, optics, and architecture.
关键词： liquid crystals,bioinspired,shape transformation
更新于2025-09-23 15:22:29
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Bioinspired magnetic nanoparticles as multimodal photoacoustic, photothermal and photomechanical contrast agents
摘要： Nanoparticles from magnetotactic bacteria have been used in conventional imaging, drug delivery, and magnetic manipulations. Here, we show that these natural nanoparticles and their bioinspired hybrids with near-infrared gold nanorods and folic acid can serve as molecular high-contrast photoacoustic probes for single-cell diagnostics and as photothermal agents for single-cell therapy using laser-induced vapor nanobubbles and magnetic field as significant signal and therapy amplifiers. These theranostics agents enable the detection and photomechanical killing of triple negative breast cancer cells that are resistant to conventional chemotherapy, with just one or a few low-energy laser pulses. In studies in vivo, we discovered that circulating tumor cells labeled with the nanohybrids generate transient ultrasharp photoacoustic resonances directly in the bloodstream as the basis for new super-resolution photoacoustic flow cytometry in vivo. These properties make natural and bioinspired magnetic nanoparticles promising biocompatible, multimodal, high-contrast, and clinically relevant cellular probes for many in vitro and in vivo biomedical applications.
关键词： theranostics,super-resolution,contrast agents,photomechanical,photoacoustic,magnetic nanoparticles,photothermal,circulating tumor cells,bioinspired,magnetotactic bacteria
更新于2025-09-19 17:15:36
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In Vitro Bioactivity and Biocompatibility of Bio-Inspired Ti-6Al-4V Alloy Surfaces Modified by Combined Laser Micro/Nano Structuring
摘要： The bioactivity and biocompatibility play key roles in the success of dental and orthopaedic implants. Although most commercial implant systems use various surface microstructures, the ideal multi-scale topographies capable of controlling osteointegration have not yielded conclusive results. Inspired by both the isotropic adhesion of the skin structures in tree frog toe pads and the anisotropic adhesion of the corrugated ridges on the scales of Morpho butter?y wings, composite micro/nano-structures, including the array of micro-hexagons and oriented nano-ripples on titanium alloy implants, were respectively fabricated by microsecond laser direct writing and femtosecond laser-induced periodic surface structures, to improve cell adherence, alignment and proliferation on implants. The main di?erences in both the bioactivity in simulated body ?uid and the biocompatibility in osteoblastic cell MC3T3 proliferation were measured and analyzed among Ti-6Al-4V samples with smooth surface, micro-hexagons and composite micro/nano-structures, respectively. Of note, bioinspired micro/nano-structures displayed the best bioactivity and biocompatibility after in vitro experiments, and meanwhile, the nano-ripples were able to induce cellular alignment within the micro-hexagons. The reasons for these di?erences were found in the topographical cues. An innovative functionalization strategy of controlling the osteointegration on titanium alloy implants is proposed using the composite micro/nano-structures, which is meaningful in various regenerative medicine applications and implant ?elds.
关键词： bioinspired surfaces,biocompatibility,cell adherence,femtosecond laser,bioactivity,cell alignment,Ti-6Al-4V,LIPSS
更新于2025-09-19 17:13:59
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Directed Emission from Self‐Assembled Microhelices
摘要： Bottom-up assembly can organize simple building blocks into complex architectures for light manipulation. The optical properties of self-assembled polycrystalline barium carbonate/silica double helices are studied using fluorescent Fourier and Mueller matrix microscopy. Helices doped with fluorescein direct light emission along the long axis of the structure. Furthermore, light transmission measured normal and parallel to the long axis exhibits twist sense-specific circular retardance and waveguiding, respectively, although the measurements suffer from depolarization. The helices thus integrate highly directional emission with enantiomorph-specific polarization. This optical response emerges from the arrangement of nanoscopic mineral crystallites in the microscopic helix, and demonstrates how bottom-up assembly can achieve ordering across multiple length scales to form complex functional materials.
关键词： bioinspired materials,optical microscopy,hierarchical structures,polarimetry,self-assembly
更新于2025-09-12 10:27:22
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Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging
摘要： In nature, the formation of spider silk fibers begins with dimerizing the pH-sensitive N-terminal domains of silk proteins (spidroins) upon lowering pH, which provides a natural masterpiece for programmable assembly. Inspired by the similarity of pH-dependent dimerization behaviors, here we introduce an i-motif-guided model to mimic the initial step of spidroin assembly at the subcellular level. A framework nucleic acid (FNA) nanoplatform is designed using two tetrahedral DNA nanostructures (TDNs) with different branched vertexes carrying a bimolecular i-motif and a split ATP aptamer. Once TDNs enter acidic lysosomes within living cells, they assemble into a hetero-dimeric architecture thereby enabling the formation of a larger-size framework and meanwhile subcellular imaging in response to endogenous ATP, which can be dynamically manipulated via adjusting intracellular pH and ATP level with external drug stimuli.
关键词： silk-mimicking,supermolecular assembly,bioinspired,DNA nanostructures,framework nucleic acids
更新于2025-09-09 09:28:46