- 标题
- 摘要
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- 实验方案
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Recent Advances in Biopolymers || Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques
摘要： This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic–inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries’ synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.
关键词： MAPLE and Combinatorial-MAPLE,thin films,biomedical applications,Biopolymers
更新于2025-09-19 17:13:59
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[IEEE 2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring) - Rome, Italy (2019.6.17-2019.6.20)] 2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring) - Study on a Multi-channel Switchable and Environment Self-adaptive Ultrasonic Sensor in an Erbium-doped Fiber Ring Laser
摘要： The usefulness of the information contained in biomedical data relies heavily on the reliability and accuracy of the methods used for its extraction. The conventional assumptions of stationarity and autonomicity break down in the case of living systems because they are thermodynamically open, and thus constantly interacting with their environments. This leads to an inherent time-variability and results in highly nonlinear, time-dependent dynamics. The aim of signal analysis usually is to gain insight into the behavior of the system from which the signal originated. Here, a range of signal analysis methods is presented and applied to extract information about time-varying oscillatory modes and their interactions. Methods are discussed for the characterization of signals and their underlying nonautonomous dynamics, including time-frequency analysis, decomposition, coherence analysis and dynamical Bayesian inference to study interactions and coupling functions. They are illustrated by being applied to cardiovascular and EEG data. The recent introduction of chronotaxic systems provides a theoretical framework within which dynamical systems can have amplitudes and frequencies which are time-varying, yet remain stable, matching well the characteristics of life. We demonstrate that, when applied in the context of chronotaxic systems, the methods presented facilitate the accurate extraction of the system dynamics over many scales of time and space.
关键词： phase coherence,coupling function,Biomedical signal analysis,dynamical Bayesian inference,wavelet bispectrum,cardiovascular system,time-frequency analysis,brain dynamics,time-dependent dynamics
更新于2025-09-19 17:13:59
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A Multiparametric Evaluation of Quantum Dot Size and Surface-Grafted Peptide Density on Cellular Uptake and Cytotoxicity
摘要： Despite the progress in nanotechnology for biomedical applications, great efforts are still being employed in optimizing nanoparticle (NP) design parameters to improve functionality and minimize bionanotoxicity. In this study, we developed CdSe/CdS/ZnS core/shell/shell quantum dots (QDs) that are compact ligand-coated and surface-functionalized with an HIV-1-derived TAT cell-penetrating peptide (CPP) analog to improve both biocompatibility and cellular uptake. Multiparametric studies were performed in different mammalian and murine cell lines to compare the effects of varying QD size and number of surface CPPs on cellular uptake, viability, generation of reactive oxygen species, mitochondrial health, cell area, and autophagy. Our results showed that the number of cell-associated NPs and their respective toxicity are higher for the larger QDs. Meanwhile, increasing the number of surface CPPs also enhanced cellular uptake and induced cytotoxicity through the generation of mitoROS and autophagy. Thus, here we report the optimal size and surface CPP combinations for improved QD cellular uptake.
关键词： cellular uptake,mitochondrial health,cytotoxicity,biomedical applications,reactive oxygen species,nanotechnology,autophagy,quantum dots
更新于2025-09-19 17:13:59
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[IEEE 2019 Compound Semiconductor Week (CSW) - Nara, Japan (2019.5.19-2019.5.23)] 2019 Compound Semiconductor Week (CSW) - Multi-wavelength DFB laser array in InAs/GaAs quantum dot material epitaxially grown on Silicon
摘要： A ?rst proof-of-concept mm-sized implantable device using ultrasonic power transfer and a hybrid bi-directional data communication link is presented. Ultrasonic power transfer enables miniaturization of the implant and operation deep inside the body, while still achieving safe and high power levels (100 W to a few mWs) required for most implant applications. The current implant prototype measures 4 mm 7.8 mm and is comprised of a piezoelectric receiver, an IC designed in 65 nm CMOS process and an off-chip antenna. The IC can support a maximum DC load of 100 W for an incident acoustic intensity that is 5% of the FDA diagnostic limit. This demonstrates the feasibility of providing further higher available DC power, potentially opening up new implant applications. The proposed hybrid bi-directional data link consists of ultrasonic downlink and RF uplink. Falling edge of the ultrasound input is detected as downlink data. The implant transmits an ultra-wideband (UWB) pulse sequence as uplink data, demonstrating capability of implementing an energy-ef?cient M-ary PPM transmitter in the future.
关键词： implantable biomedical devices,active recti?er,mm-sized implants,ultrasonic power transfer,piezoelectric receivers,bi-directional data communication,CMOS,antennas,IMD,AC-DC converter,radio transmitters
更新于2025-09-19 17:13:59
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PHOTOVOLTAIC DRIVEN RESONANT WIRELESS ENERGY TRANSFER SYSTEM FOR IMPLANTABLE ELECTRONIC SENSOR
摘要： In order to energize the biomedical implantable electronic devices wirelessly for in vivo health monitoring of patients in an isolated, outdoor and inaccessible environment, an alternate driving energy source is highly desirable. In pertinent to this, a photovoltaic driven wireless energizing system has been explored. The system is designed to convert solar energy to a high frequency energy source so as to facilitate energy transfer through resonant inductive link to the automated bio-medical sensing system allied with the receiver unit. The received power is observed to be 286 mW for the coil separation gap of 5 cm and load value of 40 Ω at the resonant frequency of 772.3 kHz. The automated biomedical smart sensor is competent to acquire the body parameter and transmit the consequent telemetry data from the body to the data recording segment. The real-time body temperature parameter of di?erent living beings has been experimented, and to ensure the accuracy of the developed system, the observed parameter has been matched with a calibrated system. The proposed scheme can be suitable for monitoring wirelessly other in vivo health parameters such as blood pressure, bladder pressure, and physiological signals of the patients.
关键词： resonant wireless energy transfer,health monitoring,biomedical,photovoltaic,implantable electronic sensor
更新于2025-09-19 17:13:59
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[IEEE 2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring) - Rome, Italy (2019.6.17-2019.6.20)] 2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring) - High Power Terahertz Source Based on Planar Antenna Integrated Vacuum Photodiode
摘要： The usefulness of the information contained in biomedical data relies heavily on the reliability and accuracy of the methods used for its extraction. The conventional assumptions of stationarity and autonomicity break down in the case of living systems because they are thermodynamically open, and thus constantly interacting with their environments. This leads to an inherent time-variability and results in highly nonlinear, time-dependent dynamics. The aim of signal analysis usually is to gain insight into the behavior of the system from which the signal originated. Here, a range of signal analysis methods is presented and applied to extract information about time-varying oscillatory modes and their interactions. Methods are discussed for the characterization of signals and their underlying nonautonomous dynamics, including time-frequency analysis, decomposition, coherence analysis and dynamical Bayesian inference to study interactions and coupling functions. They are illustrated by being applied to cardiovascular and EEG data. The recent introduction of chronotaxic systems provides a theoretical framework within which dynamical systems can have amplitudes and frequencies which are time-varying, yet remain stable, matching well the characteristics of life. We demonstrate that, when applied in the context of chronotaxic systems, the methods presented facilitate the accurate extraction of the system dynamics over many scales of time and space.
关键词： phase coherence,coupling function,Biomedical signal analysis,dynamical Bayesian inference,wavelet bispectrum,cardiovascular system,time-frequency analysis,brain dynamics,time-dependent dynamics
更新于2025-09-19 17:13:59
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[IEEE 2019 IEEE International Conference on Computation, Communication and Engineering (ICCCE) - Fujian P.R, China (2019.11.8-2019.11.10)] 2019 IEEE International Conference on Computation, Communication and Engineering (ICCCE) - The IR Drop Effect of 2T1C and 3T1C Driving Modes in Top Emission AMOLED
摘要： The immune system in homo sapiens protects the body against diseases by identifying and attacking foreign pathogens. However, when the system misidenti?es native cells as threats, it results in an auto-immune response. The auto-antibodies generated during this phenomenon may be identi?ed through the indirect immuno?uorescence test. An important constituent process of this test is the automated identi?cation of antigen patterns in the cell images, which is the focus of this research. We perform a detailed literature review and present a framework to automate the identi?cation of antigen patterns. The ef?cacy of the framework, demonstrated on the MIVIA ICPR 2012 HEp-2 Cell Contest and SNP HEp-2 Cell datasets, suggests that the algorithm is comparable with the state-of-the-art approaches.
关键词： anti-nuclear antibody testing,Biomedical imaging,HEp-2 cells,laws texture measure,indirect immuno?uorescence test
更新于2025-09-19 17:13:59
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MAPbI <sub/>3</sub> Self‐Recrystallization Induced Performance Improvement for Oxygen‐Containing Functional Groups Decorated Carbon Nanotube‐Based Perovskite Solar Cells
摘要： The specific interactions (i.e., molecular recognitions) between receptors at membrane and ligands at the extracellular matrix (ECM) are crucial in various cellular processes [1]. The occurrence of these molecular recognitions as a consequence of ECM remodeling gives rise to specific cell-signaling and intracellular cascades. Therefore the natural receptor(cid:1)ligand interactions are central in physiology and pathological processes. From the point of view of materials science, the specific binding of natural receptors to targeted ligands also shows great promise in the design of biomaterials with advanced affinity [2]. Despite the successful development of a plethora of biomaterials or biomedical devices based on natural receptor(cid:1)ligand interactions in the last decade, natural species like proteins or DNAs still have inherent drawbacks [3,4]. First, the chemical and physical stability and shelf life of natural receptors or antibodies are limited, which restricts their applications in nonphysiological environments. Second, it is expensive, time-consuming, and labor-intensive to isolate and purify them from nature or by biochemical synthesis. Finally, practical requirements in materials science are more extensive than the limited yield, functions, and diversity in currently available molecular recognition in nature. As a result, an advanced material design with more durable and robust receptor-like substitutions is sought [5].
关键词： Bioaffinity,Synthetic Receptors,Affinity Screening,Molecular Imprinting,Biomedical Applications
更新于2025-09-19 17:13:59
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[IEEE 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Chicago, IL, USA (2019.6.16-2019.6.21)] 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - GaSb Solar Cells Grown by MOCVD via IMF on GaAs
摘要： An aging and more sedentary population requires interventions aimed at monitoring physical activity, particularly within the home. This research uses simulation, optimization, and regression analyses to assess the feasibility of using a small number of sensors to track movement and infer physical activity levels of older adults. Based on activity data from the American Time Use Survey and assisted living apartment layouts, we determined that using three to four doorway sensors can be used to effectively capture a suf?cient amount of movements in order to estimate activity. The research also identi?ed preferred approaches for assigning sensor locations, evaluated the error magnitude inherent in the approach, and developed a methodology to identify which apartment layouts would be best suited for these technologies.
关键词： successful aging,gerontology,smart homes,Biomedical monitoring,sensors,senior citizens,geriatrics
更新于2025-09-19 17:13:59
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[IEEE 2019 IEEE 4th International Conference on Image, Vision and Computing (ICIVC) - Xiamen, China (2019.7.5-2019.7.7)] 2019 IEEE 4th International Conference on Image, Vision and Computing (ICIVC) - A Method for Generating Spray Trajectory of a Shoe Sole Based on Laser Vision
摘要： A ?rst proof-of-concept mm-sized implantable device using ultrasonic power transfer and a hybrid bi-directional data communication link is presented. Ultrasonic power transfer enables miniaturization of the implant and operation deep inside the body, while still achieving safe and high power levels (100 W to a few mWs) required for most implant applications. The current implant prototype measures 4 mm 7.8 mm and is comprised of a piezoelectric receiver, an IC designed in 65 nm CMOS process and an off-chip antenna. The IC can support a maximum DC load of 100 W for an incident acoustic intensity that is 5% of the FDA diagnostic limit. This demonstrates the feasibility of providing further higher available DC power, potentially opening up new implant applications. The proposed hybrid bi-directional data link consists of ultrasonic downlink and RF uplink. Falling edge of the ultrasound input is detected as downlink data. The implant transmits an ultra-wideband (UWB) pulse sequence as uplink data, demonstrating capability of implementing an energy-ef?cient M-ary PPM transmitter in the future.
关键词： piezoelectric receivers,bi-directional data communication,mm-sized implants,CMOS,ultrasonic power transfer,active recti?er,IMD,antennas,radio transmitters,AC-DC converter,implantable biomedical devices
更新于2025-09-19 17:13:59