- 标题
- 摘要
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Quantitative evaluation of skin surface roughness using optical coherence tomography in vivo
摘要： The quantitative monitoring of skin topography is important in the field of cosmetics and dermatology. The most widespread method for determining skin roughness in vivo is to use skin microrelief, PRIMOS device, which allows a noninvasive, fast and direct measurement of the skin surface. However, it has drawbacks, such as the interference of backscattering from volumetric skin and motion artifacts. In this study, we demonstrate the potential of OCT for providing reliable and quantitative skin surface roughness. In order to evaluate the performance of OCT for skin surface analysis, different types of skin phantoms are fabricated and measured. We utilize OCT to identify the effect of cosmetics as well as human skin topology for various aging groups and different skin regions. Skin surface roughness parameters based on ISO 25178 part 2 standard definitions are then derived from home-built image processing software and compared with one acquired from PRIMOS. Our results show that skin surface geometry acquired from 3D OCT images is well quantified to complex wrinkle structure and robust to the angle of the subject. Since OCT enables to present topology and volumetric skin anatomy quantitative skin simultaneously, it would be a useful tool to deliver comprehensive and intuitive information in dynamic skin observations.
关键词： Surfaces,Tomography,Biomedical image processing
更新于2025-09-10 09:29:36
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Synthesis and Characterization of Photoresponsive Macromolecule for Biomedical Application
摘要： Azobenzene, a photo switcher, has attracted increasing interest due to its structural response to photo stimulus in the field of information science and chemical sensing in the recent decades. However, limited water solubility and cytotoxicity restrained their applications in the biomedical field. In research, HA-AZO has been designed as a water soluble photo switcher in biomedical application. Synthesized HA-AZO had good water-solubility and a stable π-π? transition absorbance peak trans-isomer. With exposure to UV, transformation from trans-isomer to cis-isomer of HA-AZO could be realized according to UV spectra. Reversely, trans-isomer could be gradually recovered from cis-isomer in the dark. Simultaneously, quick response and slow recovery could be detected in the process of structural change. Moreover, repeated illumination was further used to detect the antifatigue property of HA-AZO, which showed no sign of fatigue during 20 circles. The influence of pH value on UV spectrum for HA-AZO was investigated in the work. Importantly, in acid solution, HA-AZO no longer showed any photoresponsive property. Additionally, the status of HA-AZO under the effect of UV light was investigated by DLS results and TEM image. Finally, in vitro cytotoxicity evaluations were performed to show the effects of photoresponsive macromolecule on cells.
关键词： photoresponsive macromolecule,photo switcher,biomedical application,hyaluronic acid,azobenzene
更新于2025-09-10 09:29:36
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Nanobiosensors: Next Generation Point-of-Care Biomedical Devices for Personalized Diagnosis
摘要： Imagine an era where patients will be able to tell the doctor that they themselves have detected the target molecule (e.g., antigen, proteins, chemical molecule, etc.) related to a disease using a personalized diagnostic tools (e.g., glucose for diabetes, Salmonella typhi for typhoid, bilirubin for anemia). This may help the clinicians to quickly design the adequate therapeutic strategies for patients. A biosensor based diagnostic technology promises to do just that-quick onsite diagnosis. Biosensors in general are stand alone miniature portable devices that can detect range of analytes quickly with the help of transducers that converts the biological response into measurable analytical signals. It represents a rapidly expanding field currently and is expected to reach $22.68 billion market by 2020. Moving this proof-of-concept device for everyday analysis of biological or chemical samples has involved tremendous development in biosensors research [1]. Therefore, many such diagnostic devices are available in the global market for various medical purpose such as; malaria testing kit [(CareStart? Malaria HRP2/PLDH; Access Bio, United States) (Maleriscan? Malaria Pf/PAN; Bhat Bio-Tech (P) Ltd., India)], hCG based pregnancy testing kits [(Pregnosis?; Hoffmann-La Roche Ltd., Montreal), (Velocit?; Dr.Reddy’s India)], and portable glucometers [(CareStart? G6PD, Access Bio, United States)] etc. Although these miniaturized devices are extensively fabricated and possess good market potential, research to improvise the existing designs in terms of relativity, sensitivity, detection time, and point-of-care diagnosis are still underway [2].
关键词： Nanobiosensors,Point-of-Care,Biomedical Devices,Personalized Diagnosis
更新于2025-09-10 09:29:36
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Size Modification of Optically Active Contamination-Free Silicon Nanoparticles with Paramagnetic Defects by Their Fast Synthesis and Dissolution
摘要： Contamination-free silicon-based nanoparticles (NPs) with several modalities are developed in this work. They are formed by non-toxic laser-assisted decomposition of silicon microgranules homogeneously dispersed in deionized water. Precise control of numerous experimental parameters allows repeatable fine tuning of nanoparticle size solving significant lacks of a direct laser ablation routine. Such a method provokes a huge amount of paramagnetic defect states of optically active silicon NPs that can serve as a contrast agent for magnetic resonance and nonlinear optical imaging. Perspectives of their bioapplication are driven by detected their fast size degradation in a NaCl-based medium.
关键词： optical properties,laser ablation,silicon nanoparticles,biomedical applications,electron paramagnetic resonance
更新于2025-09-10 09:29:36
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Mini-review: Laser-induced formation of microbubbles - biomedical implications
摘要： Recent work is summarized that shows how microbubbles may have potential utility in biomedical situations as (i) highly localized generators of intense whitelight in an aqueous environment, (ii) disruptors of matter in aqueous solution, (iii) essential precursors in laser-writing structures on substrates on which biological cells can be spatially aligned, and (iv) mediators in fabrication of hierarchical nano-structures that enhance signals in biological Raman spectroscopy. Indeed, microbubbles generated upon laser irradiation of surfaces have many more ramifications than originally thought, with implications in laser modification of surfaces producing either hydrophilicity or hydrophobicity. Many more possibilities remain to be explored and exploited.
关键词： Raman spectroscopy,biomedical applications,laser-induced formation,microbubbles,surface modification
更新于2025-09-10 09:29:36
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Spotlight on Bioimaging and Signal Processing [In the Spotlight]
摘要： The Bio-Imaging and Signal Processing Technical Committee (BISP-TC) of the IEEE Signal Processing Society (SPS) promotes activities in the broad technical areas of computerized image and signal processing with a clear focus on applications in biology and medicine. Specific topics of interest include image reconstruction, compressed sensing, superresolution, image restoration, registration and segmentation, pattern recognition, object detection, localization, tracking, quantification and classification, machine learning, multimodal image and signal fusion, analytics, visualization, and statistical modeling. Application areas covered by the TC include biomedical imaging from nano to macroscale, encompassing all modalities of molecular imaging and microscopy, anatomical imaging, and functional imaging, as well as genomic signal processing, computational biology, and bioinformatics, with the ultimate overarching aim of enabling precision medicine.
关键词： Biomedical Imaging,Bioimaging,Machine Learning,Precision Medicine,Signal Processing
更新于2025-09-10 09:29:36
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Effects of Surface Passivation on Photoluminescence Properties and Biomedical Imaging of Graphene Quantum Dots
摘要： Owing to fluorescence properties and small size, graphene quantum dots (GQDs) have been investigated for biomedical imaging. Although GQDs demonstrate some desirable properties, their poor stability and low biocompatibility have applications in various aspects. Therefore, in this study, we synthesized surface-passivated GQDs and studied their properties. GQDs were prepared using thermal exfoliation of graphite oxide, followed by nitric acid refluxing. Then GQDs were passivated with polyethylene glycol (PEG) using hydrothermal at 120 ℃ for 72 h. Both GQDs and GQDs-PEG were characterized by transmission electron microscopy, UV-Vis absorption and photoluminescence spectroscopy. Compared with GQDs, GQDs-PEG exhibit higher fluorescence intensity and fluorescent quantum yield. Also, GQDs-PEG demonstrates less cytotoxicity than GQDs in terms of cell survival rate in MTT assay. Our findings demonstrate that both fluorescence characteristics and biocompatibility of GQDs can be improved by PEG surface passivation, and GQDs-PEG is desirable for biomedical imaging.
关键词： surface passivation,biomedical imaging,graphene quantum dots,photoluminescence,polyethylene glycol
更新于2025-09-10 09:29:36
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[IEEE 2018 IEEE 38th International Conference on Electronics and Nanotechnology (ELNANO) - Kiev (2018.4.24-2018.4.26)] 2018 IEEE 38th International Conference on Electronics and Nanotechnology (ELNANO) - A New Technology of Bactericidal Processing of Koch's Bacillus on the Basis of Pulsed Electromagnetic Radiation
摘要： The technology of bactericidal and sterilizing processing of Koch’s Bacillus on the basis of pulsed electromagnetic ultraviolet (UV) radiation has been proposed. This technology is based on the pulse method of bactericidal processing of objects with low-temperature plasma using pulse sterilizer developed by the authors. The mathematical model of generating broadband pulsed radiation by the source of powerful optical radiation, based on the technique of charged particles accelerator, has been developed. The structure of the electromagnetic radiation source of the high-intensity optical range has been presented. The research of the bactericidal effect of pulsed UV radiation on Koch’s bacillus has been conducted.
关键词： Koch’s bacillus,forplasma,bactericidal and sterilizing processing,capacitive storage,pulse sterilizer,hard ultraviolet,biomedical technologies,magneto-plasma compressor
更新于2025-09-10 09:29:36
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[IEEE 2018 IEEE 38th International Conference on Electronics and Nanotechnology (ELNANO) - Kiev (2018.4.24-2018.4.26)] 2018 IEEE 38th International Conference on Electronics and Nanotechnology (ELNANO) - Mueller Matrix Polarimetric Imaging of Prostate Tissue
摘要： Polarimetric imaging technique is a beneficial and non-destructive tool for probing the structural properties of different tissues. The obtained optical signature matrix will help clinicians to evaluate the condition of tissues. As the polarimetric properties of tissues are dependent to the structure and cellular skeleton, time lapsing may introduce variation in the polarization properties. Based on this, in the current study we have investigated the polarization properties of human prostate tissue over time. In this regard we have used polarization imaging technique based on Mueller matrix imaging and polar decomposition of Mueller matrix for extraction of polarization indicators. The tests have been performed for sample tissues immediately after surgery, and at intermittent intervals. The polarization properties have been re-measured, to follow the changes in the polarization properties of tissue over the time. The results of our study indicate that the diattenuation increases and depolarization decreases over time which can be associated with the structural properties of tissue accordingly.
关键词： Biomedical Imaging,Mueller matrix imaging,Polarization imaging,Prostate Tissue
更新于2025-09-10 09:29:36
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[IEEE 2018 2nd International Conference on Biomedical Engineering (IBIOMED) - Bali, Indonesia (2018.7.24-2018.7.26)] 2018 2nd International Conference on Biomedical Engineering (IBIOMED) - Study of Midfield Wireless Power Transfer for Implantable Medical Devices
摘要： Mid-?eld wireless power transfer (MF-WPT) is a scheme developed for transcutaneous power transfer to micro-implants kept deep inside the body in GHz frequency. With deep seated implants, the possible locations available for application increases to almost the entire body. But, this advantage of applicability is severely limited as the power delivered to the micro implants by MF-WPT is very low -in the range of few 100W. Yet, the mid-?eld operations have higher ef?ciency in miniaturized weakly coupled coil implants compared to traditional near-?eld system. So, with improvement in certain aspects, MF-WPT is expected to play a vital role in biomedical ?eld. For the same reason this paper focuses on analyses of literature available in various aspects of MF-WPT, its challenges, drawbacks and future scope of the scheme in medical ?eld.
关键词： Mid?eld wireless power transfer,Wireless Power Transfer(WPT),Biomedical device
更新于2025-09-10 09:29:36