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A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging
摘要： A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron-functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe, i.e. they are highly water-soluble, very stable in physiological medium, they do not aggregate in PBS, possess high quantum yield and finally they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were performed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.
关键词： molecular Imaging,Fluorescent probes,boron functionalization,aza-BODIPY,Water-soluble fluorophores
更新于2025-09-23 15:23:52
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Lewis-Acid-Catalyzed BODIPY Boron Functionalization Using Trimethylsilyl Nucleophiles
摘要： A novel and straightforward strategy for boron functionalization in boron dipyrromethenes (BODIPYs) is developed. In particular, this synthetic strategy provides new possibilities for the synthesis of sp2 N-substituted (B-NCS and -NCO), benzotriazole- and trifluoroacetamide-substituted BODIPYs that were hitherto unknown. These new BODIPYs display an array of highly desirable photophysical properties (0.04 < Φ f < 0.86), paving the road for further investigations in material applications.
关键词： photophysical properties,boron functionalization,trimethylsilyl nucleophiles,Lewis acid catalysis,BODIPY
更新于2025-09-09 09:28:46