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Fluorine-containing graphene quantum dots with a high singlet oxygen generation applied for photodynamic therapy
摘要： Recently, graphene quantum dots (GQDs) have been extensively studied in biomedical areas such as bio-imaging, bio-sensing and photothermal therapy due to their superior optical and physiochemical properties compared to traditional organic biomarkers. Application of GQDs in photodynamic therapy (PDT) has been explored since 2014, but currently the main challenges are inadequate singlet oxygen (1O2) quantum yield (QY), poor solubility and biocompatibility. Herein, we report on the synthesis of a new kind of fluorine-containing GQDs (F-GQDs) by an oxidative cutting method using fluorinated graphite as the raw material. The as-synthesized F-GQDs sample demonstrates an average particle size of 2.1 nm with the fluorine doping content of 1.43%. The F-GQDs have a more excellent water solubility and biocompatibility than the GQDs, and emit strong green fluorescence at 365 nm excitation with the relative fluorescence QY of 13.72%. Moreover, the fluorescence imaging effect as well as photodynamic activity successfully tested in both in vitro HepG2 cell line model and a 3D multicellular spheroids model that mimics the tumour microenvironment. Further studies using UV-visible spectroscopy through the degradation of water-soluble 9,10-anthracenediyl-bis(methylene) dimalonic acid(ABDA) demonstrate that the F-GQDs sample generate 1O2 efficiently (QY = 0.49) under a visible light irradiation. Compared to non-fluorinated GQDs, the as-reported F-GQDs manifest to be a more promising photosensitizer for image-guided PDT.
关键词： singlet oxygen,photodynamic therapy,biocompatibility,fluorine-containing,graphene quantum dots
更新于2025-09-19 17:13:59
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Preparation and Surface Properties Study of Novel Fluorine-Containing Methacrylate Polymers for Coating
摘要： A new structural fluorine-containing methacrylate monomer CH2=C(CH3)COOC–(CF3)2CF2CF2CF3 (5) was synthesized derived from perfluoro-2-methyl-2-pentene (D2). A homopolymer of 5 and copolymers of 5 and methacrylate with different alkyl chain length (chain length n = 1, 2, 4, 6, 8, 12, 18) were obtained. These new fluorinated acrylate polymers showed excellent water and oil repellency. The contact angle of the films of the homopolymer and part of the copolymers were similar with the corresponding polymers prepared from CH2=CHC(O)OCH(C3F7)(CF(CF3)2), but greater than that of the C6F13(CF3)CHOC(O)CH=CH2 homopolymer. The structure-property relationship research indicated that the copolymers’ hydrophobicity decreased first and then increased with the increase of alkyl chain length. Td of all the polymers were greater than 220 ?C and Tg fluctuated within the range of ?51~103.8 ?C. Contact angle and Tg could be adjusted by controlling the feed ratio of monomer to meet the requirements of technical indicators in the practical applications. The outstanding liquid repellency and thermal stability make monomer 5 a promising alternative to perfluorinated long-chain fluorosurfactants.
关键词： free radical copolymerization,fluorine-containing methacrylate,thermal property,repellency,fluorocarbon coating
更新于2025-09-09 09:28:46