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oe1(光电查) - 科学论文

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出版时间
  • 2017
研究主题
  • Fractional order differentiation
  • Level set
  • Active contour model
  • Image segmentation
应用领域
  • Optoelectronic Information Science and Engineering
机构单位
  • Shenzhen University
  • Stony Brook University
134 条数据
?? 中文（中国） ▾

  • Fractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody – OS2966

    摘要： Monoclonal antibodies targeting cytokines are administered parenterally for the systemic treatment of severe psoriasis. However, systemic exposure to the biologic increases the risk of side-effects including immunosuppression, whereas only a small fraction of the active molecules actually reaches the target organ, the skin. This preclinical study examines the feasibility of delivering a humanized anti-CD29 monoclonal antibody (OS2966) topically to skin using minimally-invasive fractional laser ablation. This approach would enable the targeted use of a biologic for the treatment of recalcitrant psoriatic plaques in patients with less widespread disease while minimizing the risk of systemic exposure. First, the effect of a wide range of laser poration conditions on skin permeation and deposition of OS2966 was tested in vitro to determine optimal microporation parameters. Subsequently, confocal laser scanning microscopy was employed to visualize the distribution of fluorescently-labelled OS2966 in skin. The results demonstrated that delivery of OS2966 into and across skin was feasible. Above fluences of 35.1 J/cm2, skin deposition and permeation were statistically superior to passive delivery reaching values up to 3.7 ± 1.2 μg/cm2 at the most aggressive condition. Selective targeting of the skin was also possible since ≥70% of the OS2966 was delivered locally to the skin. Although nanogramme quantities were able to permeate across skin, these amounts were orders of magnitude lower than levels seen following subcutaneous or intravenous injection and would result in minimal systemic exposure in vivo. The diffusion of fluorescently-labelled OS2966 into the skin surrounding the pores was clearly higher than in intact skin and demonstrated the feasibility of delivering the antibody at least as deep as the dermo-epithelial junction, a critical border region where inflammatory cells cross to promote disease progression. These preliminary results confirm that fractional laser ablation can be used for the cutaneous delivery of OS2966 and now preclinical/clinical studies are required to demonstrate therapeutic efficacy.

    关键词： fractional laser ablation,cutaneous delivery,OS2966,psoriasis,monoclonal antibodies

    更新于2025-11-21 11:08:12

  • Computer-Assisted Diagnosis for Diabetic Retinopathy Based on Fundus Images Using Deep Convolutional Neural Network

    摘要： Diabetic retinopathy (DR) is a complication of long-standing diabetes, which is hard to detect in its early stage because it only shows a few symptoms. Nowadays, the diagnosis of DR usually requires taking digital fundus images, as well as images using optical coherence tomography (OCT). Since OCT equipment is very expensive, it will benefit both the patients and the ophthalmologists if an accurate diagnosis can be made, based solely on reading digital fundus images. In the paper, we present a novel algorithm based on deep convolutional neural network (DCNN). Unlike the traditional DCNN approach, we replace the commonly used max-pooling layers with fractional max-pooling. Two of these DCNNs with a different number of layers are trained to derive more discriminative features for classification. After combining features from metadata of the image and DCNNs, we train a support vector machine (SVM) classifier to learn the underlying boundary of distributions of each class. For the experiments, we used the publicly available DR detection database provided by Kaggle. We used 34,124 training images and 1,000 validation images to build our model and tested with 53,572 testing images. The proposed DR classifier classifies the stages of DR into five categories, labeled with an integer ranging between zero and four. The experimental results show that the proposed method can achieve a recognition rate up to 86.17%, which is higher than previously reported in the literature. In addition to designing a machine learning algorithm, we also develop an app called 'Deep Retina.' Equipped with a handheld ophthalmoscope, the average person can take fundus images by themselves and obtain an immediate result, calculated by our algorithm. It is beneficial for home care, remote medical care, and self-examination.

    关键词： deep convolutional neural network,mobile app,fractional max-pooling,support vector machine,diabetic retinopathy,fundus images,teaching-learning-based optimization

    更新于2025-09-23 15:23:52

  • Vehiculización de fármacos asistida por láser

    摘要： Absorption of topical products through the epidermis is limited by the skin's barrier function. Numerous techniques and agents such as microneedling, dermabrasion, radiofrequency, and lasers have been used to increase penetration within an approach known as transdermal drug delivery. One of these techniques is laser-assisted drug delivery (LADD), which often uses ablative fractional lasers (CO2 or erbium:YAG lasers) because of their capacity to produce microscopic ablated channels. The parameters in LADD need to be adjusted to the patient, the skin condition and its location, and the drug. LADD has been used with various topical products, such as corticosteroids, photosensitizers, and immunotherapy agents (imiquimod or 5-fluorouracil) to treat numerous conditions, including scars, nonmelanoma skin cancer, and photodamage. LADD is a promising technique that enhances the absorption of topical molecules while adding the synergic effect of the laser.

    关键词： Laser-assisted drug delivery,CO2 laser,Ablative fractional laser,Hypertrophic scars,Keloid scars

    更新于2025-09-23 15:23:52

  • Angle-dependent excitonic luminescence in semiconductor microtube cavity: The self-absorption effect

    摘要： We obtain a Liouville theorem for the semilinear fractional CR covariant equation Pα/2u = up (1 ≤ α < 2) on the Heisenberg group Hn. For this purpose, we extend the fractional equation to sub-Laplace Neumann problem on Hn × R+. Then the conclusion is derived by applying the CR inversion and moving plane method to the Neumann problem. Our result is a generalization for the corresponding one to P1/2u = up.

    关键词： Liouville theorem,moving plane method,fractional CR covariant equation,Heisenberg group,CR inversion

    更新于2025-09-23 15:23:52

  • Fractional-Order Spatial Steganography and Blind Steganalysis for Printed Matter: Anti-Counterfeiting for Product External Packing in Internet-of-Things

    摘要： This paper advocates a novel conceptual formulation of the fractional-order spatial steganography and blind steganalysis for printed matter, which can be efficiently employed in the anti-counterfeiting for product external packing in Internet-of-Things (IoT). Traditional digital steganography is not printable. Within the limits of our knowledge, until now, there are not a well-established steganography and a corresponding steganalysis for printed matter in IoT, which should receive desired attention. Fractional calculus has potentially received prominence in applications in the domain of image processing mainly because of its strengths like long-term memory, nonlocality, and weak singularity. Therefore, in an attempt to overcome the aforementioned technical limitation of traditional digital steganography, this work has studied here, as an interesting theoretical problem, would it be possible to apply the capability of preserving the edges and textural details of fractional calculus to the achievement of the steganography and steganalysis for printed matter in IoT. Motivated by this inspiration, in this paper, this work introduces a novel conceptual formulation of a Fractional-order Spatial Steganography (FSS) and a Fractional-order Blind Steganalysis (FBS) for printed matter. At first, according to the opponent process theory of colour vision, to better achieve the imperceptibility of the hidden secret information, this work uses both the self-similar complex textures in a neighborhood and the opponent channel of blue versus yellow to implement FSS for printed matter. Secondly, without requiring a priori knowledge regarding the characteristics of the original carrier image, hidden secret image, and steganography, a FBS, a fractional-order multimodal function optimization algorithm, is proposed. Finally, the efficient capability of hiding secret information of FSS and that of detecting secret information of FBS are analyzed in detail experimentally, respectively. These two important advantages lead to the superiority of the proposed approach for defending against statistics attack, rotation and distortion attack, cropping attack, scaling attack, noise attack, and colour copy attack. The main contribution of this paper is the first preliminary attempt of a feasible achievement of a spatial steganography and a blind steganalysis for printed matter.

    关键词： Printed Matter,Anti-counterfeiting,Fractional-order spatial steganography,Fractional calculus,Fractional-order blind steganalysis

    更新于2025-09-23 15:22:29

  • [IEEE 2018 International Conference on Microwave and Millimeter Wave Technology (ICMMT) - Chengdu, China (2018.5.7-2018.5.11)] 2018 International Conference on Microwave and Millimeter Wave Technology (ICMMT) - Detection of Uniformly Accelerated Spinning Target Based on OAM Beams

    摘要： In recent years, it has been validated that electromagnetic (EM) wave carrying orbital angular momentum (OAM) can be exploited to detect the angular velocity of spinning targets with uniform velocity. In this paper, the detection method of uniformly accelerated spinning target using OAM beams is studied. The time-frequency analysis approaches, including the Wigner-Ville distribution (WVD) and the fractional order Fourier transform (FRFT), are used to analyze the rotational Doppler frequency shift caused by spinning targets. Simulation results indicate that the resolution of acceleration is dependent on the spectrum width of time-frequency diagrams of the echo signal.

    关键词： OAM beams,rotational Doppler frequency shift,uniformly accelerated spinning target,Wigner-Ville distribution,fractional order Fourier transform

    更新于2025-09-23 15:22:29

  • [IEEE 2018 IEEE 3rd International Conference on Signal and Image Processing (ICSIP) - Shenzhen, China (2018.7.13-2018.7.15)] 2018 IEEE 3rd International Conference on Signal and Image Processing (ICSIP) - A Fractional-order Differential Based Variational Model for Image Blind Deblurring

    摘要： Image deblurring is a fundamental problem in image processing. The blind deblurring is a more challenge problem because we need to recover the true image but the blur type is unknown. The total variation method has been proposed by Tony Chan et al. [1] for image blind deblurring, but it often produces the staircase effect. To avoid this effect, in this paper, based on the fractional-order differential, we propose a novel variational method for blind deblurring. Moreover, in image regularization, we add a fractional-order edge detect function to preserve sharp edges. The primal-dual algorithm are developed to solve the proposed model. Numerical experiments show that our method is able to get the sharp images without the staircase effect and correctly estimate the unknown blur kernel.

    关键词： fractional-order differential,primal-dual algorithm,Image deblurring

    更新于2025-09-23 15:22:29

  • A 65 nm 19.1-to-20.4 GHz Sigma-Delta Fractional-N Frequency Synthesizer with Two-Point Modulation for FMCW Radar Applications

    摘要： A 19.1-to-20.4 GHz sigma-delta fractional-N frequency synthesizer with two-point modulation (TPM) for frequency modulated continuous wave (FMCW) radar applications is presented. The FMCW synthesizer proposes a digital and voltage controlled oscillator (D/VCO) with large continuous frequency tuning range and small digital controlled oscillator (DCO) gain variation to support TPM. By using TPM technique, it avoids the correlation between loop bandwidth and chirp slope, which is beneficial to fast chirp, phase noise and linearity. The start frequency, bandwidth and slope of the FMCW signal are all reconfigurable independently. The FMCW synthesizer achieves a measured phase noise of ?93.32 dBc/Hz at 1MHz offset from a 19.25 GHz carrier and less than 10 μs locking time. The root-mean-square (RMS) frequency error is only 112 kHz with 94 kHz/μs chirp slope, and 761 kHz with a fast slope of 9.725 MHz/μs respectively. Implemented in 65 nm CMOS process, the synthesizer consumes 74.3 mW with output buffer.

    关键词： FMCW radar,fractional-N,two-point modulation,CMOS,phase locked loop,frequency synthesizer

    更新于2025-09-23 15:22:29

  • CPW-Fed Triple High Rejection Notched UWB & X-Band Antenna on Silicon for Imaging & Wireless Applications

    摘要： In this paper, compact Coplanar Waveguide feed antenna covering UWB & X-Band signals (2.98GHz-13.34GHz) is presented. Antenna also offers triple notched band elimination (WiMAX: 3.40GHz-3.95GHz, WLAN: 4.50GHz-6.34GHz & Downlink Satellite System: 7.11GHz-7.802GHz) which are due to insertion of stub and etching of slots. Antenna is fabricated and characterized on silicon for imaging and wireless applications with having fractional bandwidth of 133%. The antenna offers gain, radiation efficiency and group delay between 3.26dBi-8.00dBi, 84%-92% and ≤ ±1.0ns respectively for the entire of its bandwidth. Isolation of antenna in face to face and side to side orientations are < -25dB with very less distortion presented in the transmission and reception of the signal. The radiations emitted by the antenna are observed as dipole like pattern in E-plane and omni-directional in H-plane.

    关键词： radiation efficiency,Silicon,high rejection,fractional bandwidth,gain

    更新于2025-09-23 15:22:29

  • [IEEE 2018 China International SAR Symposium (CISS) - Shanghai (2018.10.10-2018.10.12)] 2018 China International SAR Symposium (CISS) - 3D Velocity Estimation for Moving Targets via Geosynchronous Bistatic SAR

    摘要： Recently, geosynchronous synthetic aperture radar (GEO-SAR), which can achieve continuous Earth observation missions with large coverage and short revisit period, has drawn extensive attention. The wide-swath imaging mode of GEO-SAR presents great potentials for bistatic observation applications. Geosynchronous bistatic SAR (GEO-BiSAR) can not only imaging task, but also provide the complete conditions for ground moving-target indication (GMTI). In this paper, the 3D velocity estimation for moving target via GEO-BiSAR are investigated. And the velocity estimation problem is extended to three-dimensional (3D) domain, considering that targets always move in a 3D space. To solve the 3D velocity of moving targets via GEO-BiSAR, the 3D velocity raw signal model is established, and a method based on fractional Fourier transform (FrFT) is proposed. First, the Doppler centroids and Doppler rates in the GEO-BiSAR are estimated by the FrFT. Second, one of the Doppler rates is used to estimate the azimuth velocity. Then, the range and height velocity are obtained by solving a Doppler centroid equation set. Finally, simulation experiments are presented to demonstrate the effectiveness of the method.

    关键词： 3D Velocity Estimation,GMTI,fractional Fourier transform,Geosynchronous bistatic SAR

    更新于2025-09-23 15:22:29