研究目的
To review and discuss the technique of laser-assisted drug delivery (LADD), particularly using ablative fractional lasers, to enhance the penetration of topical drugs through the skin barrier for treating various dermatological conditions.
研究成果
LADD is a promising method to enhance topical drug absorption and achieve synergistic effects with laser treatment. It has been successfully applied in various dermatological conditions, but further research is needed to optimize parameters, ensure safety, and expand applications beyond dermatology.
研究不足
The technique carries risks such as erythema, vesiculation, crusting, and scarring, especially with high fluences and densities. There is a potential for infection due to dermal exposure, and not all topical drugs are suitable for intradermal use. Optimal parameters and long-term safety are not fully established, and comparative studies between techniques are limited.
1：Experimental Design and Method Selection:
The paper is a review article, not an experimental study, so it does not describe a specific experimental design. It summarizes existing research on LADD, including the use of different lasers and parameters.
2：Sample Selection and Data Sources:
Based on literature review of studies involving human and animal models, clinical trials, and case reports.
3：List of Experimental Equipment and Materials:
Various lasers are mentioned, such as CO2 lasers (10,600 nm), Er:YAG lasers (2,940 nm), Er:Glass lasers (1,550 nm), and others, but no specific models or brands are detailed. Topical drugs like corticosteroids, photosensitizers, and immunotherapy agents are discussed.
4：Experimental Procedures and Operational Workflow:
General steps include laser application to create microchannels, followed by topical drug application within 30 minutes to 6 hours, with considerations for patient selection, laser parameters, and safety measures.
5：Data Analysis Methods:
Not specified as it is a review; references to statistical analyses in cited studies are mentioned but not detailed.
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