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Material Reliability of Low-Temperature Boron Deposition for PureB Silicon Photodiode Fabrication
摘要： The chemical-vapor deposition conditions for the growth of pure boron (PureB) layers on silicon at temperatures as low as 400oC were investigated with the purpose of optimizing photodiodes fabricated with PureB anodes for minimal B-layer thickness, low dark current and chemical robustness. The B-deposition is performed in a commercially-available Si epitaxial reactor from a diborane precursor. In-situ methods commonly used to improve the cleanliness of the Si surface before deposition are tested for a deposition temperature of 450oC and PureB layer thickness of 3 nm. Specifically, high-temperature baking in hydrogen, and exposure to HCl are tested. Both material analysis and electrical diode characterization indicate that these extra cleaning steps degrade the properties of the PureB layer and the fabricated diodes.
关键词： silicon,photodiodes,chemical-vapor deposition,Pure boron,diborane
更新于2025-09-04 15:30:14
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Transmission Spectroscopy in Noninvasive Blood Glucose Measurement
摘要： The use of laser diodes and photodiodes in transmission spectroscopy has some effects (temperature, time, spectral, and spatial) reducing the accuracy of glucose measurement. These effects can be reduced by using a (1600 ± 3) nm laser in combination with fixation and occlusion of the tissue area under examination. In this work, a method is suggested that allows spatial displacements of the system to be taken into account. A number of methods for reducing the effect of the thermal drift of the diodes are also suggested. A portable noninvasive optical glucose meter implemented using these methods provides high clinical performance: more than 97% of the measurements are in the A and B zones of the Parkes error grid.
关键词： photodiodes,transmission spectroscopy,noninvasive blood glucose measurement,laser diodes,thermal drift,spatial displacements
更新于2025-09-04 15:30:14
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Silica bead-based microfluidic device with integrated photodiodes for the rapid capture and detection of rolling circle amplification products in the femtomolar range
摘要： The rapid and sensitive detection of specific nucleic acid sequences at the point-of-care (PoC) is becoming increasingly in demand for a variety of emergent biomedical applications ranging from infectious disease diagnostics to the screening of antimicrobial resistance. To meet such demand, considerable efforts have been invested towards the development of portable and integrated analytical devices combining microfluidics with miniaturized signal transducers. Here, we demonstrate the combination of rolling circle amplification (RCA)-based nucleic acid amplification with an on-chip size-selective trapping of amplicons on silica beads (~8 nL capture chamber) coupled with a thin-film photodiode (200 × 200 μm area) fluorescence readout. Parameters such as the flow rate of the amplicon solution and trapping time were optimized as well as the photodiode measurement settings, providing minimum detection limits below 0.5 fM of targeted nucleic acids and requiring only 5 μL of pre-amplified sample. Finally, we evaluated the analytical performance of our approach by benchmarking it against a commercial instrument for RCA product (RCP) quantification and further investigated the effect of the number of RCA cycles and elongation times (ranging from 10 to 120 minutes). Moreover, we provide a demonstration of the application for diagnostic purposes by detecting RNA from influenza and Ebola viruses, thus highlighting its suitability for integrated PoC systems.
关键词： Microfluidics,Infectious disease diagnostics,Silica microbeads,Photodiodes,Rolling circle amplification
更新于2025-09-04 15:30:14