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A Phase Sensitivity-Enhanced Surface Plasmon Resonance Biosensor Based on ITO-Graphene Hybrid Structure
摘要： In this paper, a surface plasmon resonance (SPR) sensor based on the hybrid structure of silver (Ag)-indium tin oxide (ITO)-graphene is proposed and investigated. SPR biosensors are subdivided into three kinds of structures Ag, Ag-graphene, and Ag-ITO-graphene, when carried out using their respective optimized structure parameters. According to our analysis and comparison, the ITO-assisted SPR biosensor has an optimal reflectivity of 3.587 × 10?8 and a maximum phase sensitivity of 1.707 × 106°/RIU, which shows that ITO can be employed to further enhance the SPR sensing performance even with the existence of graphene.
关键词： Surface-plasmon-resonance,Hybrid structure,Phase sensitivity,Reflectivity
更新于2025-09-23 15:21:01
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Two-dimensional transition metal dichalcogenides mediated long range surface plasmon resonance biosensors
摘要： Two-dimensional transition metal dichalcogenides (TMDCs), as promising alternative plasmon supporting materials to graphene, exhibit potential applications in sensing. Here, we propose a TMDCs-mediated long range surface plasmon resonance (LRSPR) imaging biosensor, which shows tremendous improvements in both imaging sensitivity (> ×2) and detection accuracy (> ×10) as compared to conventional surface plasmon resonance (cSPR) biosensor. It is found that the imaging sensitivity of the LRSPR biosensor can be enhanced by the integration of TMDC layers, which is di?erent from the previously reported graphene-mediated cSPR imaging sensor whose imaging sensitivity decreases with the number of graphene layers. This imaging sensitivity enhancement e?ect for the TMDCs-mediated LRSPR sensor originates from the propagating nature of the LRSPR at both interfaces of sensing medium/gold and gold/cytop layer (with matching refractive index as sensing medium). By tuning the thickness of gold ?lm and cytop layer, it is possible to achieve optimized imaging sensitivity for LRSPR sensor with any known integrated number of TMDC layers and the analyte refractive index. The proposed TMDCs-mediated LRSPR imaging sensor could provide potential applications in chemical sensing and biosensing applications.
关键词： detection accuracy,biosensor,long range surface plasmon resonance,Two-dimensional transition metal dichalcogenides,imaging sensitivity
更新于2025-09-23 15:21:01
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[IEEE 2017 IEEE Workshop on Recent Advances in Photonics (WRAP) - Hyderabad (2017.12.18-2017.12.19)] 2017 IEEE Workshop on Recent Advances in Photonics (WRAP) - Synthesis of Gold Nanorods with Tunable Surface Plasmon Resonance for Near-Infrared Biosensing Applications
摘要： Single-crystalline gold nanorods of average size 121nm x8.4nmwith defect free surface are synthesized with surface plasmon resonance in the near-infrared region. The surface plasmon resonance is readily tunable from 900-1300nm by maintaining the pH of the growth solution while varying the Au3+/Ag+ ratio.
关键词： surface plasmon resonance,sensing,gold nanorods
更新于2025-09-23 15:21:01
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Cuvette-based microfluidic device integrated with nanostructures for measuring dual Localized Surface Plasmon Resonance (LSPR) signals
摘要： A spectrophotometer that uses a localized surface plasmon resonance phenomenon is a powerful measurement tool in the biotechnology and bioanalysis fields. We propose a novel cuvette design type that can be used for universal spectrophotometers. The novel cuvette design needs a few μl reagent for measuring, and also two chips for measurement can be loaded and measured at the same time. A new cuvette can easily be used several times because of sample chips to be loaded and unloaded since they are mechanically mounted by screws. Therefore, it can offer advantages to users in terms of cost and time. We verify its possibility for use in the biotechnology and bioanalysis fields by a signal enhancement and dual signal detection.
关键词： spectrophotometer,bioanalysis,nanostructures,microfluidic device,biotechnology,Localized Surface Plasmon Resonance,LSPR
更新于2025-09-23 15:21:01
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Polymer Fiber Optic Sensors – A Mini Review of their Synthesis and Applications
摘要： Fiber optic sensors (FOSs) are optical fiber based sensing devices that have been widely used to detect physical, chemical and biological parameters. Polymer optical fibers (POFs), an important type of optical fibers, have been stifled their talents in the field of optical sensing due to the overwhelming popularity of glass optical fibers (GOFs). The unique physical and chemical properties of POFs start attracting interests to be utilized in the fabrication of high performance sensors in recent years. This article reviews the recent progress of POFs based FOSs. In particular, the article will focus on novel techniques implemented on the POF sensor fabrication, including monolayer graphene, evanescent wave absorption, localized surface plasmon resonance and fiber Bragg grating.
关键词： Localized surface plasmon resonance,Fiber Bragg gratings,Evanescent wave,Microstructured polymer optical fiber,Polymer fiber optic sensor
更新于2025-09-23 15:21:01
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[Methods in Enzymology] Modern Approaches in Drug Discovery Volume 610 || A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays
摘要： Over the past 30 years, drug discovery has evolved from a pure phenotypic approach to an integrated target-based strategy. The implementation of high-throughput biochemical and cellular assays has enabled the screening of large compound libraries which has become an important and often times the main source of new chemical matter that serve as starting point for medicinal chemistry efforts. In addition, biophysical methods measuring the physical interaction (affinity) between a low molecular weight ligand and a target protein became an integral part of hit validation/optimization to rule out false positives due to assay artifacts. Recent advances in throughput, robustness, and sensitivity of biophysical affinity screening methods have broadened their application in hit identification and validation such that they can now complement classical functional readouts. As a result, new target classes can be accessed that have not been amenable to functional assays. In this chapter, two affinity screening methods, differential scanning fluorimetry and surface plasmon resonance, which are broadly utilized in both academia and pharmaceutical industry are discussed in respect to their use in hit identification and validation. These methods exemplify how assays which differ in complexity, throughput, and information content can support the hit identification/validation process. This chapter focuses on the practical aspects and caveats of these techniques in order to enable the reader to establish their own affinity-based screens in both formats.
关键词： hit validation,drug discovery,surface plasmon resonance,affinity screening,differential scanning fluorimetry,biophysical methods,hit identification
更新于2025-09-23 15:21:01
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PRECISE FINITE DIFFERENCE ANALYSIS OF LORENTZ FORCE ACTING ON METAL NANOPARTICLE IRRADIATED WITH LIGHT
摘要： A ?nite di?erence method in the frequency domain is evaluated to clarify characteristics of the Lorentz force exerted on a metal nanoscale particle by light irradiation. Numerical results are compared with exact values obtained from Mie theory to show that applying a smoothing algorithm to the surface of a nanoparticle increases the accuracy of the simulation. Analysis of the Lorentz force exerted between two spheres aligned closely indicates that strong forces cause the spheres to attract each other at the plasmon resonant frequency. It was also noticed that application of the smoothing algorithm was indispensable in order to achieve the above result.
关键词： plasmon resonance,finite difference method,Lorentz force,light irradiation,metal nanoparticle,Mie theory
更新于2025-09-23 15:21:01
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Up-Conversion Luminescence Properties of Lanthanide-Gold Hybrid Nanoparticles as Analyzed with Discrete Dipole Approximation
摘要： Up-conversion nanoparticles (UCNP) under near-infrared (NIR) light irradiation have been well investigated in the field of bio-imaging. However, the low up-conversion luminescence (UCL) intensity limits applications. Plasmonic modulation has been proposed as an effective tool to adjust the luminescence intensity and lifetime. In this study discrete dipole approximation (DDA) was explored concerning guiding the design of UCNP@mSiO2-Au structures with enhanced UCL intensity. The extinction effects of gold shells could be changed by adjusting the distance between the UCNPs and the Au NPs by synthesized tunable mesoporous silica (mSiO2) spacers. Enhanced UCL was obtained under 808 nm irradiation. The original theoretical predictions could not be demonstrated to full extend by experimental data, indicating that better models for simulation need to take into account in homogeneities in particle morphologies. Yet, one very certain conclusion resulting from the DDA calculations and experiments is that the absorbance can blue-shift with more Au NPs added and the absorbance can-red shift for samples with enhanced silica sizes in the UCNP@mSiO2-Au structures. Furthermore, when the DDA model is more consistent with the practical structure (dispersed Au NPs instead of Au shell), the theoretical absorbance occurs almost the same as the practical absorbance. All in all, the DDA could fit the extinction effect of Au perfectly and be suitable for guiding how to design the UCNP and Au.
关键词： lanthanide-based composites,surface plasmon resonance,up conversion nanoparticles,discrete dipole approximation
更新于2025-09-23 15:21:01
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Modulation of localized surface plasmon resonances of a silver nanoparticle array upon the presence of MoS2 coatings or underlying thin films
摘要： There has been recently a growing interest in studying light-matter coupling using supported metallic nanostructures arranged into periodic arrays. The influence on the layer thickness of two-dimensional materials such as molybdenum disulfide MoS2 on the plasmonic behaviour of these arrays has become of great relevance due to the favorable bonding between S (sulfide atom) and metal atoms such as gold and silver as well as the variation of optical transition of MoS2 depending on the atomic thickness of the film. In this work, we have numerically studied the change in absorption spectra of an ordered array of silver nanoparticles AgNPs when attached to glass as well as to glass coated with different layers of MoS2. This arrangement was compared to an AgNPs attached to glass and post coated with MoS2 films of increasing thickness. It was shown that an overcoating of four MoS2 layers results in an increased plasmonic sensitivity compared to uncoated glass/AgNPs interface. Replacing the glass substrate by glass coated with MoS2 of different thickness and with added AgNPs shows a significant to the red shift with increasing MoS2 layers. This band is due to strong excitation-plasmon coupling of the silver lattice with MoS2 layers. Important is the fact that the electrical field is strongly enhanced beneath the MoS2/AgNPs barrier. One also observes a significant enhancement of the sensitivity. Hence, the design of more sensitive AgNPs/MoS2 based-plasmonic biosensors could be reached. Indeed, we show that AgNPs coating with few layers of MoS2 leads to approximately a 210.26% higher sensitivity.
关键词： Sensitivity,MoS2,Silver nanoparticle array,BioSensors,Localized surface plasmon resonance
更新于2025-09-23 15:21:01
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Lab-on-Fiber: Plasmonic Nano-arrays for Sensing
摘要： For sensors based on electromagnetic resonance whether surface plasmon resonance (SPR) or localized surface plasmon resonance (LSPR), enhancing the light-matter interactions is the most critical and important way to improve the performance of sensors. Plasmonic nano-arrays is a kind of periodic metal or dielectric nanostructure formed by nanofabrication technology and it can effectively enhance the light-matter interactions by tuning structural parameters to excite different optical effects due to its ultra-high degree of freedom. At the same time, a plug-and-play, remote micro sensor suitable for limited environments (such as in vivo) may be realized due to the rise of lab-on-fiber technology and the progress of nanofabrication technology for unconventional substrates (such as optical fiber tip). In this paper, the advantages and disadvantages of different nanofabrication technologies are briefly introduced and compared firstly, and then the applications of optical fiber sensors (OFS) based on different plasmonic nano-arrays are reviewed. Plasmonic nano-arrays OFS are divided into two categories: one is the refractive index sensor based on the sensitivity of the array to the surrounding environment; the other is the surface enhanced Raman scattering (SERS) sensor based on the enhancement ability of the local electric field around the array. In this review, the present sensors are compared and analyzed from aspects of the geometry, material and dimension of plasmonic nano-arrays and the main research directions and progress are summarized. Finally, the future development trend is proposed.
关键词： surface plasmon resonance,localized surface plasmon resonance,optical fiber sensors,nanofabrication technologies,Plasmonic nano-arrays,lab-on-fiber
更新于2025-09-23 15:19:57