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Contemporary Polymer-Based Nanoparticle Systems for Photothermal Therapy
摘要： Current approaches for the treatment of cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, are limited by various factors, such as inadvertent necrosis of healthy cells, immunological destruction, or secondary cancer development. Hyperthermic therapy is a promising strategy intended to mitigate many of the shortcomings associated with traditional therapeutic approaches. However, to utilize this approach effectively, it must be targeted to specific tumor sites to prevent adverse side effects. In this regard, photothermal therapy, using intravenously-administered nanoparticle materials capable of eliciting hyperthermic effects in combination with the precise application of light in the near-infrared spectrum, has shown promise. Many different materials have been proposed, including various inorganic materials such as Au, Ag, and Germanium, and C-based materials. Unfortunately, these materials are limited by concerns about accumulation and potential cytotoxicity. Polymer-based nanoparticle systems have been investigated to overcome limitations associated with traditional inorganic nanoparticle systems. Some of the materials that have been investigated for this purpose include polypyrrole, poly-(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), polydopamine, and polyaniline. The purpose of this review is to summarize these contemporary polymer-based nanoparticle technologies to acquire an understanding of their current applications and explore the potential for future improvements.
关键词： polydopamine,polypyrrole,polymeric nanoparticle,photothermal therapy,polyaniline
更新于2025-09-23 15:23:52
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Benzyl ester dendrimer silicon phthalocyanine based polymeric nanoparticle for in vitro photodynamic therapy of glioma
摘要： A novel second generation benzyl ester dendrimer silicon phthalocyanine (D-SiPc) was synthesized and encapsulated into amphiphilic block copolymers to form polymeric nanoparticles (D-SiPc@m). The cellular uptake and subcellular localization of D-SiPc@m in U251 glioma cells were studied by confocal laser scanning imaging. The cellular uptake of D-SiPc@m into U251 glioma cells reached the peak after being treatment for 6 h, and D-SiPc@m was localized into both mitochondria and lysosomes. The photodynamic efficacy of D-SiPc@m against U251 glioma cells was evaluated. D-SiPc@m exhibited high photo-cytotoxicity toward U251 glioma cells under laser irradiation. This polymeric nanoparticle could be a promising candidate for therapy of glioma.
关键词： polymeric nanoparticle,subcellular localization,photodynamic therapy,glioma,silicon phthalocyanine
更新于2025-09-09 09:28:46