- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
UV light irradiated trifluoromethylation of diheteroaryl disulfides with CF3SO2Na
摘要： A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) is been developed. The features of simple and clean reaction conditions, in moderate to good yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially pharmaceutically active compounds.
关键词： trifluoromethylation,heterocycle,disulfides,ketones,radical reactions
更新于2025-09-23 15:23:52
-
Anti-Markovnikov Hydroazidation of Alkenes by Visible Light Photoredox Catalysis
摘要： The anti-Markovnikov hydroazidation of alkenes has been accomplished using [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as photocatalyst and trimethylsilyl azide as azidating agent. The reactions were greatly facilitated by water, whose beneficial effect can be attributed to its participation in the reaction as the hydrogen donor, as indicated by deuterium isotope experiments. The reactions can be effected under solvent free conditions in the presence of water. 4-Dimethylaminopyridine also exhibited a beneficial effect on the reactions. The present method enabled hydroazidation of several types of unactivated alkenes with good yield and high regionselectivity.
关键词： hydroazidation,water,trimethylsilyl azide,radical reactions,photoredox catalysis
更新于2025-09-23 15:22:29
-
Photocatalyzed thiol-alkene coupling: Mechanistic study and polymer synthesis
摘要： Due to the “click” chemistry characteristics of the thiol–ene reaction, these transformations have been gaining an increasing amount of attention in current chemical research. The high efficiency and selectivity of these transformations have been useful for many areas of study, from small molecule organic synthesis, to polymer synthesis and functionalization, to bioconjugation reactions. In this work, a study of a novel method of photochemical thiol–ene reactions using alkyl halides and an tris [2-phenylpyridinato-C2,N]iridium(III) (Ir(ppy)3) photocatalyst is investigated. This process is shown to progress rapidly and has the benefit of low catalyst and initiator concentrations relative to reagents as well as mild conditions associated with photochemical processes. To understand the mechanism of this process, catalyst and initiator concentrations and other reaction conditions are varied. To demonstrate the utility of this process, a step-growth thiol–ene polymer is synthesized using dithiol and diene monomers and a crosslinked polymer network is synthesized as well.
关键词： thiol–ene,radical reactions,step-growth polymerization,polymer network,photochemistry
更新于2025-09-19 17:15:36