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Progress in Endovenous Pulsed Laser Ablation
摘要： Continuous-wave (CW) lasers have been commonly used for endovenous laser ablation (EVLA). However, as some undesired side effects such as postoperative pain and bruising occasionally happens, longer laser wavelength and specially-fabricated laser fibers have been developed. On the other hand, the pulsed-wave (PW) laser, which has a heat production control by thermal relaxation, is independently developed for EVLA. This article discusses the implication of PW laser in EVLA from a theoretical point of view and a newly-developed micropulsation (MP) is introduced as a new concept. Since the MP yields adequate blood and vein wall heat degeneration by microseconds laser emission, efficacy and safety are improved compared with CW laser or conventional PW laser. Initial clinical outcome is favorable and promising for painless EVLA using inexpensive bare fiber.
关键词： varicose vein,thermal relaxation time,micropulsation,endovenous laser ablation,clear tip mode
更新于2025-09-23 15:19:57
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Thermal Relaxation Features of Residual Stresses Arising upon Laser Shock Processing of Heat-Resistant Materials
摘要： In this paper, we study the thermal relaxation features of compressive residual stresses generated during laser-shock wave processing in high-alloyed heat-resistant Iron GH2036 alloy. A finite element modeling of thermal relaxation of the generated compressive residual stresses was performed. The features of the thermal effects on the redistribution of the compressive residual stresses in the temperature range from 200 to 650°C are studied. Based on comparative analysis, the results of the finite element modeling correlated well with the experimental data known in the literature.
关键词： residual stresses,thermal relaxation,finite element modeling,laser-shock wave treatment
更新于2025-09-19 17:13:59
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Photoexcitation Dynamics of Thiocyanate-Bound Heme Proteins Using Femtosecond Infrared Spectroscopy
摘要： Myoglobin (Mb) and hemoglobin (Hb) have been used as model systems to understand the relationships between protein function, structure, and dynamics. These studies have primarily been carried out by observing the (re)binding between ferrous heme proteins and neutral ligands. Ferric heme proteins also bind to various anionic ligands, such as CN?, N3?, OCN?, and SCN?. Only a few anion-bound ferric heme proteins have been investigated for ligand-binding dynamics.1–4 Although CN?-bound Mb (MbCN) was reported to be photostable, i.e., not photodeligated by a visible photon, recent study using Raman spectroscopy claimed a photodeligation quantum yield for MbCN of 0.75.5 Thus, the photostability of ?-bound MbCN is still in question. At room temperature, N3?-bound Mb (MbN3) exists in both high spin (HS) and low spin (LS) complexes. When MbN3 absorbs a visible photon, the ligand is not dissociated; instead the excited MbN3 undergoes a thermal relaxation process involving a spin transition.3 Recently, we have shown that photoexcited OCN?-bound Mb and OCN?-bound Hb are also photostable, losing their excess energy via thermal relaxation after rapid electronic relaxation.4 Here, to determine the general excitation properties of anion-bound heme proteins after absorption of a visible photon, we have extended our study of photoexcitation dynamics to SCN?-bound ferric Mb (MbNCS) and Hb (HbNCS).
关键词： Femtosecond vibrational spectroscopy,Thiocyanate-bound myoglobin,Electronic relaxation,Ferric heme proteins,Thermal relaxation
更新于2025-09-10 09:29:36