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oe1(光电查) - 科学论文

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  • Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

    摘要： The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug‐cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau? Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

    关键词： additive manufacturing,printing pharmaceuticals,orally disintegrating printlets (ODPs),3D printed drug products,personalized medicines,taste masking,three‐dimensional printing,rapid prototyping,orally disintegrating tablets (ODTs)

    更新于2025-09-19 17:13:59

  • [IEEE 2019 49th European Microwave Conference (EuMC) - Paris, France (2019.10.1-2019.10.3)] 2019 49th European Microwave Conference (EuMC) - Viability of using additive manufacturing for horn antennas fed with empty substrate integrated waveguide

    摘要： Substrate integrated waveguides reduce the losses when compared to traditional planar transmission lines, while maintaining their low profile, and low cost manufacturing. The losses have been further reduced by partially or fully removing the dielectric, and many microwave devices have been successfully implemented with empty substrate integrated waveguides, including H-plane horn antennas. The directivity of the horn antenna can be increased using 3D pyramidal horns, and sacrificing the low profile. However, the low cost can be maintained by using additive manufacturing. In this work the viability of using additive manufacturing for two horn antennas fed with empty substrate integrated waveguide is studied.

    关键词： three-dimensional printing,pyramid horn antenna,substrate integrated waveguide,Empty substrate integrated waveguide,exponential horn antenna

    更新于2025-09-16 10:30:52