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Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging
摘要： We investigated the feasibility of using terahertz (THz) reflection imaging to detect keratinizing squamous cell carcinoma (SCC) of the tongue. Four fresh keratinizing SCC tissues were studied, which had been surgically resected. All of the keratinizing SCCs were well distinguished from normal healthy tissues. We showed that the tumor regions exhibited low THz reflection despite having higher water content than normal regions. The refractive indices and absorption coefficients were low in the tumor tissues despite the relatively high water content. Our results showed that there were dominant factors such as keratin pearls, other than the water content affecting the THz reflection signal.
关键词： Optical diagnostics for medicine,Tissue diagnostics,Terahertz imaging,Medical and biological imaging,Terahertz spectroscopy
更新于2025-09-23 15:23:52
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Analysis of Plasmonic Gold Nanostar Arrays with the Optimum Sers Enhancement Factor on the Human Skin Tissue
摘要： We analyze the performance of the surface-enhanced Raman spectroscopy (SERS) substrate based on high-density gold nanostar nanoparticle (GNS) arrays assembled on the gold film and embedded in the human skin tissue as a surrounding medium. A self-assembled monolayer (SAM) of 3-aminopropyltriethoxy silane (APTES) is used for immobilizing GNSs on the Au film. The GNS–Au film and GNS–GNS coupling in the gap regions and also the GNSs interparticle coupling at their branches are observed, so the GNS arrays show more field enhancements and the sensitivity of the GNS sensor can be increased further. When the SERS substrate based on the GNS arrays is excited by a 785-nm laser line, a maximum enhancement factor (EF) of 109 is observed. It is demonstrated that the normalized EF depends on the geometry of the GNSs, the thickness of the Au film, and the separation distance between the cores of the GNSs.
关键词： thin films,spectroscopy,biomaterials,tissue diagnostics,nanostars,surface plasmons,plasmonics
更新于2025-09-12 10:27:22