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Synthesis, characterization and photophysical properties of meso-indole-boron-dipyrromethene derivatives and their cell imaging and viscosity sensing
摘要： Based on the molecular design and structural modification of boron-dipyrromethene (BODIPY), two new BODIPY derivatives with meso-substituted functional indole moieties were successfully prepared. These new compounds were characterized by NMR, HRMS and FTIR, exhibiting the different UV-vis and PL spectral phenomena because of their varied molecular structures in various solvents and different degrees of negative solvatochromism. Theoretical calculations and CV results show that the substituted NO2 group at 5-position of indole is favorable for increasing the oxidation potential of the molecules, while the NH2 group is the opposite. These two BODIPY derivatives have different sensitivities to pH changes, and can be appropriately applied as cell imaging materials due to their good physical chemical characteristics and excellent biocompatibility. In particular, the fluorescence characteristics of BODIPY derivative with the substituted NH2 group at 5-position of indole show a good solvent viscosity dependence, highlighting its potential application for testing the intracellular viscosity changes of the living cell in disease diagnosis.
关键词： meso-indole boron-dipyrromethene derivatives,photoluminescence,fluorescence characteristics,cell imaging,viscosity sensing
更新于2025-09-23 15:23:52
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The Oscillation Dynamics of Droplets Subject to Electrowetting Actuation
摘要： The dynamic behavior of an Electrowetting-on-Dielectrics (EWOD) actuation process can be linked to certain fluid properties of the actuated polar liquid droplet. After actuation, inertia will lead to droplet oscillations where the contact angle asymptotically approaches the newly created surface tension equilibrium value. The decay behavior, frequency and amplitude of these oscillations can be related to material parameters such as density, viscosity and mass. In this work we study the characteristics of these oscillations, present simulation results and develop a measurement setup for first observations of oscillations on deionized water droplets. We show that there is a big difference between two grounding schemes, in particular regarding the dynamic movement of the liquid-gas interface. It turns out that only an electrical grounding from below leads to utilizable oscillations. Finally we point towards applications for future Lab-on-a-Chip applications.
关键词： actuator,FEM simulation,electrowetting,viscosity sensing,droplet oscillations,Lab-on-a-Chip
更新于2025-09-23 15:22:29