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Improvement in reading performance through training with simulated thalamic visual prostheses
摘要： Simulations of artificial vision are used to provide the researcher an opportunity to explore different aspects of visual prosthesis device design by observing subject performance on various tasks viewed through the simulation. Such studies typically use normal, sighted subjects to measure performance at a given point in time. Relatively few studies examine performance changes longitudinally to quantitatively assess the benefits from a training plan that would be akin to post-implantation rehabilitation. Here, we had six normal, sighted subjects use a standard reading task with daily practice over eight weeks to understand the effects of an intensive training schedule on adaptation to artificial sight. Subjects read 40 MNREAD-style sentences per session, with a new set each session, that were presented at five font sizes (logMAR 1.0–1.4) and through three center-weighted phosphene patterns (2,000, 1,000, 500 phosphenes). We found that subjects improved their reading accuracy across sessions, and that the training lead to an increase of reading speed that was equivalent to a doubling of available phosphenes. Most importantly, the hardest condition, while initially illegible, supported functional reading after training. Consistent with experience-driven neuroplastic changes, gaps in the training schedule lead to transient decreases in reading speed, but, surprisingly, not reading accuracy. Our findings contribute to our larger project of developing a thalamic visual prosthesis and to post-implant rehabilitation strategies.
关键词： training,simulation,rehabilitation,artificial vision,reading performance,visual prosthesis,phosphene patterns
更新于2025-09-23 15:23:52
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A review on the current status of retinal prostheses (bionic eye); Pregled informacija o trenutnom stanju retinalnih proteza (bioni?ko oko);
摘要： Argus? II, the first retinal prosthesis is approved for the treatment of patients with retinal pigmentosis. 2011 has received the CE (European Committee) designation and 2013 FDA (Food and Drug Administration) Approval. Retinal prosthesis provides a stable, safe and long-lasting retinal stimulation. The improvement of vision with retinal prosthesis depends on the improvement of the visual resolution, development of the correct neural form for imaging and improvement of the biological compatibility of the device to ensure durability. Once the theme of folklore and science fiction, the idea of returning sight to blind people today is approaching reality.
关键词： retinitis pigmentosa,visual prosthesis,retinal prosthesis
更新于2025-09-16 10:30:52
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[IEEE 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Honolulu, HI (2018.7.18-2018.7.21)] 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Optic nerve and retinal electrostimulation in rats: direct activation of the retinal ganglion cells
摘要： Visual prosthesis is competing with biological approaches to restore vision to the blind. Understanding and developing the ability to replicate the neural code of the retina are key factors that can bring bionic vision significant advantage. Here, electrically evoked potentials were recorded in anesthetized rats from the dorsal surface of the superior colliculus. Electrical stimuli of different amplitudes were delivered at the retina and the optic nerve. An evoked potential appeared in both cases within the first 5 ms post-stimulus suggesting that this component of the response was initiated by direct activation of the retinal ganglion cells. However, in the case of retinal neurostimulation, a second evoked potential occurred 9.0 ± 3.4 ms after the stimulus delivery. Because this component was not present in the case of optic nerve electrostimulation, it is expected to be originated by the activation of other cells in the retinal network.
关键词： superior colliculus,visual prosthesis,electrostimulation,retinal ganglion cells,optic nerve
更新于2025-09-04 15:30:14