研究目的
To study the SERS spectra of Au@Ag–4MBA@PVP plasmonic nanoparticles and investigate the difference between single nanoparticles and dimer structures, including the effects of laser power and photothermal effects.
研究成果
The study successfully measured Raman spectra of individual multilayer Au@Ag-4MBA@PVP plasmonic nanoparticles with AFM imaging guidance. It observed linear scaling of SERS spectra with laser power for both single nanoparticles and dimer structures, with the latter showing higher enhancement. Photothermal effects were identified as a cause for abnormal SERS spectra in dimer structures at higher laser powers. The research provides guidance for laser power selection in biological cell imaging using similar SERS probes.
研究不足
The study was performed on nanoparticles dried on a microslide, not in a liquid environment mimicking biological cells. AFM imaging of nanoparticles in aqueous environment is difficult.
1：Experimental Design and Method Selection:
The study involved linking an AFM with a homebuilt confocal Raman spectrometer to measure SERS spectra from separated nanoparticles. The methodology included using AFM images as guidance for Raman spectral measurement.
2：Sample Selection and Data Sources:
Au@Ag–4MBA@PVP nanoparticles were synthesized via a chemical reduction method. Samples were prepared by diluting and dripping nanoparticle solution onto a clean microslide, then drying.
3：List of Experimental Equipment and Materials:
AFM (NT-MDT Spectrum Instruments), confocal Raman microscope with a nitrogen cooled spectrometer (Horiba iHR550), 532 nm continue laser (Laser Quantum Inc.), spiral phase plate (SPP) (Holo/Or Ltd.), oil immersion objective (Olympus, 100× with NA of 1.49), edge filter (Semrock), optical fiber (Thorlabs).
4：49), edge filter (Semrock), optical fiber (Thorlabs).
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The optical path started with a 532 nm laser, followed by beam expanders, optical plates for generating radially polarized optical beam, focusing by an oil immersion objective, and Raman signal collection through an edge filter and optical fiber.
5：Data Analysis Methods:
FEM simulation was used to understand the SERS enhancement factor and photothermal behavior between single nanoparticles and dimer structures.
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