研究目的
To develop a compact, cost-effective continuous wave laser diode based photoacoustic system for diagnosing human breast cancer tissues through the use of mechanobiological properties of the tissue.
研究成果
The developed laser diode based PASR system is capable of diagnosing human breast cancer tissues by differentiating between normal and malignant tissues based on the energy of the frequency spectra. The system is compact, cost-effective, and has potential for clinical application with further development.
研究不足
The frequency sweep takes a considerable amount of time, and the system's low power results in a very low SNR of the PA signal. Automation could be a value addition to the system.
1：Experimental Design and Method Selection:
The study involves the development of a laser diode based photoacoustic spectral response (PASR) setup. The system utilizes a continuous wave laser diode modulated at specific frequencies to irradiate tissue samples, generating photoacoustic signals that reflect the mechanobiological properties of the tissue.
2：Sample Selection and Data Sources:
Standard black rubber samples and human breast tumor tissues were used. The breast tissues were formalin soaked for fixation.
3：List of Experimental Equipment and Materials:
Laser diode PL-T460B, ultrasound sensor, laser driver circuit, amplifier circuitry, heat sink, and digital oscilloscope.
4：Experimental Procedures and Operational Workflow:
The laser diode is modulated at different frequencies to irradiate the sample, and the generated photoacoustic signals are acquired using an ultrasound sensor. The signals are then amplified and recorded for analysis.
5：Data Analysis Methods:
The peak-peak amplitude of the photoacoustic signals is plotted against the respective frequencies to obtain the acoustic frequency spectra of the tissue. Energy and variance of the spectra are calculated for quantitative analysis.
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